Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses.
Abstract: To evaluate the effect of intravenous administration of romifidine on the intraocular pressure (IOP) in horses. Methods: Twenty-four horses with no ocular abnormalities. Methods: Horses were randomly assigned into two equal groups (treatment and control). All horses in the treatment group received an intravenous (IV) injection of romifidine (40 μg/kg). The horses in the control group were administrated an intravenous injection of 0.9% saline (0.4 mL/100 kg). In both groups, the IOP values were measured immediately (T0 ) pre-administration and at 5 (T5 ), 15 (T15 ), 30 (T30 ), 45 (T45 ), 60 (T60 ), 90 (T90 ), and 120 (T120 ) min after drug administration. Results: The pre-treatment values (T0 ) of IOP for right and left eyes were 24.25 ± 3.5 and 25.16 ± 3.4 mmHg, respectively. A significant decrease in IOP values was observed in both right and left eyes of the horses in treatment group at T5 , T15 , T30 , T45 , T60 , and T90 in comparison with the baseline values (P < 0.05). The lowest level of IOP in romifidine-treated groups was recorded at T45 for the right and left eyes (10.25 ± 2.3 and 11.25 ± 3.5 mmHg, respectively). Conclusions: Romifidine significantly decreased IOP in clinically normal horses and may be used safely for surgery or diagnostic ocular procedures in horses when specific control of IOP is required.
© 2014 American College of Veterinary Ophthalmologists.
Publication Date: 2014-05-19 PubMed ID: 24836894DOI: 10.1111/vop.12181Google Scholar: Lookup
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- Journal Article
- Animal Health
- Animal Studies
- Clinical Examination
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Diagnostic Technique
- Disease Treatment
- Equine Diseases
- Equine Health
- Horses
- Intraocular Pressure
- Intravenous Administration
- Ophthalmology
- Pharmacology
- Physiology
- Veterinary Medicine
- Veterinary Procedure
- Veterinary Research
Summary
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This research investigates how the intravenous administration of the drug romifidine impacts the intraocular pressure (IOP) in horses, concluding that romifidine significantly reduces IOP, meaning it could be used safely for surgical or diagnostic ocular procedures in horses when IOP control is needed.
Research Design and Methodology
- The study was conducted using 24 horses, all of which had no ocular abnormalities.
- The horses were randomly divided into two groups: a treatment group and a control group.
- In the treatment group, each horse was given an intravenous injection of romifidine, a drug commonly used for sedation purposes in veterinary medicine, at a dosage of 40 µg/kg.
- Meanwhile, the control group was given an intravenous injection of 0.9% saline solution at a volume of 0.4 mL/100 kg; saline solution has no known impact on IOP and thus served as a neutral component for comparison.
Measurements and Observations
- Intraocular pressure, or the fluid pressure within the eye, was measured for both groups before administration (T0) and then at 5, 15, 30, 45, 60, 90, and 120 minutes after the injections.
- The average pre-treatment IOP values amongst the horses were noted: roughly 24.25 mmHg for the right eye and 25.16 mmHg for the left.
Findings
- It was found that romifidine resulted in a significant reduction in IOP values in both eyes at all measured time points (from 5 minutes to 90 minutes post-administration) when compared to pre-treatment.
- The lowest IOP value in the romifidine-treated group was observed at 45 minutes after drug administration, recording around 10.25 mmHg for the right eye and 11.25 mmHg for the left.
Conclusion
- The researchers concluded that romifidine significantly reduced intraocular pressure in horses without ocular abnormalities.
- This finding suggests that romifidine could be used safely for surgeries or diagnostic ocular procedures that require specific control of intraocular pressure in horses, thus leading to perhaps safer and more effective outcomes in veterinary eye procedures.
Cite This Article
APA
Marzok MA, El-Khodery SA, Oheida AH.
(2014).
Effect of intravenous administration of romifidine on intraocular pressure in clinically normal horses.
Vet Ophthalmol, 17 Suppl 1, 149-153.
https://doi.org/10.1111/vop.12181 Publication
Researcher Affiliations
- Department of Veterinary Surgery, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, 33516, Egypt.
MeSH Terms
- Animals
- Female
- Horses / physiology
- Hypnotics and Sedatives / administration & dosage
- Hypnotics and Sedatives / pharmacology
- Imidazoles / administration & dosage
- Imidazoles / pharmacology
- Injections, Intravenous / veterinary
- Intraocular Pressure / drug effects
- Male
- Tonometry, Ocular / methods
- Tonometry, Ocular / veterinary
Citations
This article has been cited 3 times.- Mustikka MP, Pietilä EM, Mykkänen AK, Grönthal TSC. Comparison of two rebound tonometers in healthy horses.. Vet Ophthalmol 2020 Sep;23(5):892-898.
- Rizk A, Nocera I, Briganti A, Abouelnasr K, El-Khodery S, Tagawa M, Bonelli F. Dose-dependent effect of romifidine on intraocular pressure in clinically healthy buffalo (Bubalus bubalis).. Heliyon 2019 Dec;5(12):e02930.
- Romagnoli N, Al-Qudah KM, Armorini S, Lambertini C, Zaghini A, Spadari A, Roncada P. Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse.. Vet Med Sci 2017 Nov;3(4):187-197.
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