Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation.
Abstract: Administration of N-butylscopolammonium bromide (NBB) with metamizol sodium (NBBM) causes tachycardia and hypertension, and has been associated with accentuated cardiac murmurs. Objective: To evaluate the effect of a pharmacological challenge using NBBM on valvular regurgitation and cardiac murmurs in horses with aortic (AR) and mitral valve regurgitation (MR). Methods: Twenty Warmblood horses with AR and 20 with MR. Methods: Cardiac auscultation and two-dimensional (2D), M-mode, color flow, pulsed wave Doppler flow, and tissue Doppler echocardiography were performed with simultaneous ECG recording and non-invasive blood pressure measurements during rest and pharmacological challenge using 0.2 mg/kg NBB and 25 mg/kg metamizol sodium. Cardiac dimensions and functional parameters were assessed. Regurgitant jet size was subjectively evaluated, and jet area was measured. Data at rest and during pharmacological challenge were compared using repeated measures analysis or related samples Wilcoxon signed rank test. p-values were adjusted using the Benjamini-Hochberg method. Results: Compared with rest, pharmacological challenge resulted in decreased atrial and ventricular dimensions and increased aortic and pulmonary dimensions (P ≤ 0.02). Left ventricular end-diastolic diameter decreased in horses with AR (P < 0.02) but not in horses with MR. Pharmacological challenge resulted in increased median cardiac murmur intensity (P = 0.03 and P < 0.02) and jet area (P ≤ 0.02 and P = 0.03) in horses with AR and MR, respectively. Conclusions: Pharmacological challenge with NBBM affects cardiac chamber sizes, regurgitant jet, and cardiac murmur intensity in horses with AR and MR. Influences on heart rate and blood pressure should be considered during longitudinal follow-up examinations.
© 2025 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Publication Date: 2025-10-10 PubMed ID: 41070729PubMed Central: PMC12511949DOI: 10.1111/jvim.70254Google Scholar: Lookup
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Cite This Article
APA
Dufourni A, Demeyere M, Vernemmen I, Van Steenkiste G, Verhaeghe LM, van Loon G, Decloedt A.
(2025).
Effect of N-Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation.
J Vet Intern Med, 39(6), e70254.
https://doi.org/10.1111/jvim.70254 Publication
Researcher Affiliations
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Cardioteam Ghent University, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
MeSH Terms
- Animals
- Horses
- Horse Diseases / drug therapy
- Horse Diseases / diagnostic imaging
- Male
- Blood Pressure / drug effects
- Mitral Valve Insufficiency / veterinary
- Mitral Valve Insufficiency / drug therapy
- Mitral Valve Insufficiency / diagnostic imaging
- Female
- Heart Rate / drug effects
- Echocardiography / veterinary
- Aortic Valve Insufficiency / veterinary
- Aortic Valve Insufficiency / diagnostic imaging
- Aortic Valve Insufficiency / drug therapy
- Butylscopolammonium Bromide / therapeutic use
- Butylscopolammonium Bromide / pharmacology
- Butylscopolammonium Bromide / adverse effects
- Butylscopolammonium Bromide / administration & dosage
Conflict of Interest Statement
Authors declare no off‐label use of antimicrobials. The authors declare no conflicts of interest.
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