Effect of ovarian steroids on migration of uterine lumenal neutrophils and on chemokinetic factors in uterine secretions from mares.
Abstract: Incubation of blood neutrophils with uterine flushings collected from ovariectomised mares treated with oestradiol, stimulated migration under agarose, whereas flushings from mares treated with progesterone or oily vehicle, inhibited migration. After intra-uterine infusion of bacteria, however, flushings from oestradiol-treated and vehicle-treated mares inhibited migration, whereas progesterone treatment stimulated migration. Migration of uterine-derived neutrophils under agarose was less than that of blood neutrophils and was not influenced by treatment with ovarian steroids. Uterine susceptibility to infection in progesterone-treated mares was not, therefore, correlated with the migratory activities of uterine neutrophils or the chemokinetic properties of uterine secretions in vitro.
Publication Date: 1988-09-01 PubMed ID: 3181121DOI: 10.1111/j.2042-3306.1988.tb01547.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper is about conducting a study on the effect that ovarian steroids have on the migration of neutrophils in the uterine lumen and on the chemokinetic factors in uterine secretions from mares.
Overview of the Research
- The researchers used blood neutrophils from mares who had been ovariectomized (had their ovaries removed) and treated with estradiol, progesterone, or an oily vehicle substance.
- The blood neutrophils were incubated with uterine flushings from these mares to observe the effect on neutrophil migration.
- It was found that estradiol treatment stimulated migration of neutrophils, while progesterone or oily vehicle treatment inhibited the process.
Influence of Bacteria Infusion
- Post the infusion of bacteria in the uterus, the results changed: estradiol and vehicle treatment inhibited neutrophil migration, while progesterone treatment stimulated it.
- This suggests that hormonal treatment and conditions could have varying effects on immune cell behavior depending on the presence of bacteria or potential infection.
Migration of Uterine-derived Neutrophils
- The study also investigates the migration of uterine-derived neutrophils, finding it lesser compared to blood neutrophils.
- Also, the ovarian steroids treatment did not influence the migration of uterine-derived neutrophils. This strong assertive finding suggests the distinct and independent behavior of this cell type.
Correlation with Uterine Susceptibility to Infection
- Finally, the research concludes that the susceptibility of the uterus to infection in mares treated with progesterone is not correlated with the activity of uterine neutrophils or the chemokinetic properties of uterine secretions that were observed in vitro (in the lab).
- This indicates that other factors might influence the susceptibility to infection, and treatment effects might behave differently in the body compared to in vitro studies.
Cite This Article
APA
Watson ED.
(1988).
Effect of ovarian steroids on migration of uterine lumenal neutrophils and on chemokinetic factors in uterine secretions from mares.
Equine Vet J, 20(5), 368-370.
https://doi.org/10.1111/j.2042-3306.1988.tb01547.x Publication
Researcher Affiliations
- Department of Veterinary Medicine, University of Bristol, Langford.
MeSH Terms
- Animals
- Cell Migration Inhibition
- Chemotactic Factors / physiology
- Estradiol / pharmacology
- Female
- Horse Diseases / microbiology
- Horse Diseases / physiopathology
- Horses / physiology
- Neutrophils / drug effects
- Neutrophils / physiology
- Progesterone / pharmacology
- Streptococcal Infections / physiopathology
- Streptococcal Infections / veterinary
- Uterine Diseases / microbiology
- Uterine Diseases / physiopathology
- Uterine Diseases / veterinary
- Uterus / cytology
- Uterus / drug effects
- Uterus / metabolism
Citations
This article has been cited 1 times.- Funasaka N, Yoshioka M, Ueda K, Koga H, Yanagisawa M, Koga S, Tokutake K. Long-term monitoring of circulating progesterone and its relationship to peripheral white blood cells in female false killer whales Pseudorca crassidens. J Vet Med Sci 2018 Sep 13;80(9):1431-1437.
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