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Home / Equine Research Bank / J Equine Sci / Effect of Postbreeding Intramuscular Administration of Deslo...
Journal of equine science2014; 25(1); 23-27; doi: 10.1294/jes.25.23

Effect of Postbreeding Intramuscular Administration of Deslorelin Acetate on Plasma LH and Progesterone Concentrations and Conception Rate in Mares.

Abstract: To clarify effect of postbreeding intramuscular administration of deslorelin on mares, plasma LH and progesterone concentrations and conception rate were evaluated. In Experiment 1, deslorelin, buserelin, or a placebo was administered on day 9 (day 0=day of last breeding or AI). Plasma samples were collected daily from days 6 to 15, and additional samples were taken after treatment. There was a significant increase in hormonal concentrations after deslorelin treatment. In Experiment 2, deslorelin or placebo was injected on day 9. There was no difference in conception rates at days 15 and 30 between the two groups. While a single postbreeding treatment of deslorelin increased peripheral LH and progesterone concentrations, it may not affect the conception rate in mares.
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Publication Date: 2014-04-22 PubMed ID: 24834010PubMed Central: PMC4019200DOI: 10.1294/jes.25.23Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the impact of a hormone treatment, deslorelin, on the fertility hormone levels (LH and progesterone) and conception rates in mares after breeding. The findings indicate that while deslorelin increases these fertility hormone levels, it does not appear to impact overall conception rates.

Study Objective and Design

  • The main aim of this study was to explore the effects of deslorelin treatment on mares post-breeding. The focus was particularly on the levels of two fertility hormones, LH and progesterone, and on the conception rates in treated mares.
  • The research was carried out in two separate experiments. In both, deslorelin, a synthetic hormone that stimulates the release of fertility hormones, was administered into the muscles of the mares on the 9th day after breeding.

Experiment 1

  • In the first experiment, either deslorelin, another synthetic hormone called buserelin, or a placebo was given to the mares.
  • Plasma samples were taken from the mares daily from day 6 to day 15, with additional samples collected after the hormone or placebo treatment.
  • The results showed a significant increase in the mares’ plasma LH and progesterone concentrations after the deslorelin treatment. This highlights the effectiveness of this synthetic hormone in stimulating the release of these hormones in mares after breeding.

Experiment 2

  • In the second experiment, the mares were injected with either deslorelin or a placebo on the ninth day after their last breeding session.
  • Conception rates were then compared between the two groups on day 15 and day 30.
  • Unlike in the first experiment, there was no noticeable difference in conception rates between the deslorelin-treated mares and the placebo group. This finding suggests that while a single postbreeding treatment of deslorelin can elevate the levels of LH and progesterone, it does not directly influence the conception rates in mares.

Overall Findings

  • The study found that deslorelin treatment increased the plasma concentrations of two key fertility hormones, LH and progesterone, in mares after breeding.
  • Despite the change in hormone levels, no significant impact was found on the mares’ conception rates.
  • Overall, these results suggest that while postbreeding deslorelin treatment can stimulate the release of fertility hormones, this does not necessarily improve or affect conception rates in mares.

Cite This Article

APA
Kino S, Osawa T, Mizuno S, Watanabe G, Taya K, Izaike Y. (2014). Effect of Postbreeding Intramuscular Administration of Deslorelin Acetate on Plasma LH and Progesterone Concentrations and Conception Rate in Mares. J Equine Sci, 25(1), 23-27. https://doi.org/10.1294/jes.25.23

Publication

Journal of equine science
ISSN: 1340-3516
NlmUniqueID: 9503751
Country: Japan
Language: English
Volume: 25
Issue: 1
Pages: 23-27

Researcher Affiliations

Kino, Satoshi
  • Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan ; Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan.
Osawa, Takeshi
  • Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan ; NOSAI Iwate Tonanbu, Iwate 028-0542, Japan.
Mizuno, Shuji
  • NOSAI Iwate Tonanbu, Iwate 028-0542, Japan.
Watanabe, Gen
  • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Taya, Kazuyoshi
  • Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
Izaike, Yoshiaki
  • Laboratory of Theriogenology, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate 020-8550, Japan.

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