Effect of sodium bisulfate on skin and hooves of horses.
Abstract: To evaluate the safety of sodium bisulfate for use in horse barn environments by determining its irritant effect on skin and hooves. Methods: 6 female mixed-breed ponies. Methods: Sodium bisulfate was applied to clipped intact skin of 6 ponies to evaluate its irritant effect after single (48 hours) and repetitive (6 h/d for 10 days) applications; similar areas of skin were used as untreated control sites. In addition, sodium bisulfate was applied to the sole of both front hooves of each pony and covered with wet gauze, and the entire hoof was covered with adhesive tape for 48 hours. Results: Contact with moistened sodium bisulfate for 48 hours had no effect on pony skin. Contact with sodium bisulfate for 6 hours on 10 consecutive days did not cause gross changes but did cause mild to moderate microscopic changes including epidermal necrosis, hyperkeratosis, capillary congestion, edema, and diffuse mixed inflammatory cell infiltrate. All changes were limited to the epidermis and superficial dermis. Gross changes in hoof sole, signs of lameness, and increase in digital pulse pressure or pulse intensity were not detected. Conclusions: Duration of contact with sodium bisulfate in this study was in excess of that expected under typical husbandry conditions. Despite this fact, gross changes in skin and hooves were not detected. Microscopic lesions were confined to the epidermis and superficial dermis. Results suggest that contact with sodium bisulfate under these conditions is safe.
Publication Date: 2000-12-07 PubMed ID: 11108190DOI: 10.2460/ajvr.2000.61.1418Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research evaluates the safety of using sodium bisulfate in horse barn environments by studying its irritant effects on horse skin and hooves. The results of the study suggest that using sodium bisulfate under typical husbandry conditions does not have significant damaging effects on these animals.
Research Methodology
- The study was performed using six female mixed-breed ponies.
- Sodium bisulfate was applied to the skin of the ponies to examine its irritant effect after both one-time and repeated applications, using unexposed sections of skin as a control.
- For the one-time test, the substance was left on the skin for 48 hours, and for the repeated test it was applied for 6 hours a day over ten consecutive days.
- As well as the skin test, the researchers also applied sodium bisulfate to the soles of the pony’s front hooves. The substance was covered with wet gauze and the entire hoof wrapped in adhesive tape for 48 hours.
Research Results
- Initial results showed that contact with sodium bisulfate did not have a significant impact on the pony’s skin after 48 hours.
- After repeated exposure over ten days, no notable visible changes were noted, although microscopic investigation showed mild to moderate damage including episodes of skin cell death, thickening of the skin, tiny blood vessel congestion, fluid accumulation, and mixed inflammatory cell invasions.
- All observed skin changes were limited to the topmost skin layers, namely the epidermis and the superficial dermis.
- There were no observable changes in the pony’s hooves or signs of lameness, and no increase in digital pulse pressure or intensity.
Conclusions
- The research concludes that the contact duration with sodium bisulfate during this study was more extensive than what would usually be encountered under regular care conditions.
- Even with such prolonged exposure, no substantial observable changes were noted in the skin or hooves of the ponies.
- Microscopic lesions were only found in the outermost skin layers.
- The study indicates that sodium bisulfate, under the tested conditions, is safe for use in horse barn environments.
Cite This Article
APA
Sweeney CR, Habecker PL, Russell GE.
(2000).
Effect of sodium bisulfate on skin and hooves of horses.
Am J Vet Res, 61(11), 1418-1421.
https://doi.org/10.2460/ajvr.2000.61.1418 Publication
Researcher Affiliations
- Department of Clinical Studies, New Bolton Center, University of Pennsylvania, School of Veterinary Medicine, Kennett Square 19348, USA.
MeSH Terms
- Animals
- Drug Evaluation / veterinary
- Female
- Hoof and Claw / drug effects
- Horses / metabolism
- Housing, Animal
- Skin / drug effects
- Sulfates / administration & dosage
- Sulfates / pharmacology
- Temperature
- Time Factors
Citations
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