Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate.
Abstract: To determine whether topical application of 1% diclofenac sodium cream would decrease inflammation at sites of IV regional limb perfusion (IVRLP) in healthy horses. Methods: 6 healthy adult horses (12 forelimbs). Methods: Bilateral IVRLP with 2.5 g of amikacin sulfate was performed twice in each horse, with 24 hours between each session. Horses were treated with topical 1% diclofenac liposomal cream (treated limbs) or a placebo cream (control limbs). All injection sites were evaluated before the first IVRLP session and 24 hours after the second session by means of ultrasonographic examination by a trained ultrasonographer who was unaware of the treatment received. Circumferential measurements and subjective visible inflammation scores were recorded by a veterinarian who was also unaware of treatment received. Results: After IVRLP, control limbs had a significantly greater increase in subcutaneous thickness, compared with treated limbs. Ultrasonographic and visual assessment scores were significantly higher in control versus treated limbs. The mean change in limb circumference was greater, but not significantly so, in control limbs, compared with treated limbs. Conclusions: Topical application of 1% diclofenac sodium liposomal cream to sites of IVRLP in healthy horses decreased inflammation as judged by visual assessment and ultrasonography. Decreased inflammation may allow extended use of IVRLP and may result in a reduction in pain in treated horses.
Publication Date: 2009-11-03 PubMed ID: 19878013DOI: 10.2460/ajvr.70.11.1323Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This study investigates whether the use of a 1% diclofenac sodium cream can reduce inflammation in horses after undergoing an intravenous regional limb perfusion (IVRLP) procedure. The research found that the use of this topical cream did indeed lessen inflammation levels.
About the Research
- The research aims to assess the effectiveness of 1% diclofenac sodium liposomal cream in reducing inflammation at the sites subjected to IVRLP (intravenous regional limb perfusion) in healthy, adult horses.
- IVRLP is a technique used to deliver high concentrations of antimicrobials to a specific area of a limb via injection.
Methodology
- The study involved six healthy adult horses with a total of twelve forelimbs.
- IVRLP was performed twice on each horse using 2.5 g of amikacin sulfate, with a gap of 24 hours between the two sessions.
- The horses were treated either with a topical application of 1% diclofenac liposomal cream, or with a placebo cream. The allocation of the treatment or the placebo was randomized, and both the ultrasonographer and the veterinarian assessing were unaware of which treatment was given to which limb.
Findings and Conclusion
- After the procedure, limbs treated with the placebo showed a significant increase in subcutaneous thickness (which indicates increased inflammation) compared to those treated with the diclofenac sodium cream.
- Ultrasonographic and visual assessment scores for inflammation were also significantly higher in the control limbs versus the treated ones.
- The study concluded that the topical application of 1% diclofenac sodium liposomal cream at the IVRLP sites of healthy horses effectively reduced inflammation, as established by visual assessment and ultrasonography.
- The reduction in inflammation with this treatment might allow for extended use of IVRLP and potentially result in less pain for the horses undergoing these treatments.
Cite This Article
APA
Levine DG, Epstein KL, Neelis DA, Ross MW.
(2009).
Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate.
Am J Vet Res, 70(11), 1323-1325.
https://doi.org/10.2460/ajvr.70.11.1323 Publication
Researcher Affiliations
- Department of Clinical Sciences, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA. dglevine@vet.upenn.edu
MeSH Terms
- Administration, Topical
- Amikacin / administration & dosage
- Amikacin / adverse effects
- Animals
- Diclofenac / administration & dosage
- Diclofenac / chemistry
- Diclofenac / therapeutic use
- Dosage Forms
- Horse Diseases / chemically induced
- Horse Diseases / drug therapy
- Horses
- Inflammation / chemically induced
- Inflammation / drug therapy
- Inflammation / veterinary
- Injections, Intravenous
Citations
This article has been cited 5 times.- O'Brien M, Mochel JP, Kersh K, Wang C, Troy J. Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses. Front Vet Sci 2023;10:1236976.
- Yoshimura S, Koziy RV, Dickinson R, Moshynskyy I, McKenzie JA, Simko E, Bracamonte JL. Use of serum amyloid A in serum and synovial fluid to detect eradication of infection in experimental septic arthritis in horses. Can J Vet Res 2020 Jul;84(3):198-204.
- Cooper DL, Harirforoosh S. Design and optimization of PLGA-based diclofenac loaded nanoparticles. PLoS One 2014;9(1):e87326.
- Hyde RM, Lynch TM, Clark CK, Slone DE, Hughes FE. The influence of perfusate volume on antimicrobial concentration in synovial fluid following intravenous regional limb perfusion in the standing horse. Can Vet J 2013 Apr;54(4):363-7.
- Guillot M, Mespoulhes-Rivière C, Bousquet-Mélou A, Lacroix MZ, Roques BB, Lallemand EA. Pharmacokinetics, pharmacodynamics, and local tolerance at injection site of penicillin and gentamicin administered by intravenous regional limb perfusion in standing horses: comparison between weightbearing and flexed limbs. BMC Vet Res 2025 Nov 7;21(1):650.
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