Effect of topical application of 2% lidocaine gel on corneal sensitivity of clinically normal equine eyes.
Abstract: To assess the degree and duration of corneal anaesthesia provided by topical application of a non-ophthalmic 2% lidocaine gel in horses. Methods: Experimental, 'blinded', randomized prospective study. Methods: Twelve adult horses without relevant ocular abnormalities. Methods: Baseline corneal touch threshold (CTT) measurements were obtained bilaterally by use of a Cochet-Bonnet aesthesiometer just prior to topical treatment. A volume of 0.2mL of 2% lidocaine gel was administered in one randomly selected eye and the same volume of a viscous lubricant in the other eye to serve as control. The CTT value was measured on both eyes 5, 10, 20, 30, 45, 60, 75 and 90 minutes after drug application. The potential for local adverse effects following lidocaine gel application was also evaluated. Results: Mean CTT baseline measurements were not significantly different (p>0.05) between the control eyes (3.41±0.56cm) and those subsequently treated with the lidocaine gel (3.50±0.64cm). In control eyes, no significant changes in corneal sensitivity (p>0.05) occurred over time during the study period. By contrast, a marked reduction in corneal sensitivity was observed after lidocaine application, with mean CTT values significantly lower (p<0.001) than those of the control eyes from 5 to 75 minutes. A steady-state maximal corneal anaesthesia was present from 10 to 45 minutes after lidocaine gel application with mean CTT values ranging from 0.21 to 0.45cm. Corneal epithelial irregularities were detected in three lidocaine-treated eyes, but spontaneous resolution occurred within 24hours. Conclusions: Deep and sustained corneal anaesthesia is achieved after application of 2% lidocaine gel to the equine eye, with minimal changes in the corneal epithelium. It might be useful for minor ophthalmic surgeries performed in the standing sedated horse.
Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2017-09-15 PubMed ID: 29452891DOI: 10.1016/j.vaa.2017.08.008Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The article discusses an in-depth research that was conducted to understand the impact and longevity of corneal anaesthesia caused by topical application of 2% lidocaine gel in horses.
Objective and Methodology
- The purpose of the study was to evaluate the extent and duration of corneal anaesthesia in horses, induced by the topical application of a non-ophthalmic 2% lidocaine gel.
- This was an experimental, ‘blinded’, and randomized prospective study involving twelve adult horses without any substantial ocular abnormalities.
- Baseline measurements of the corneal touch threshold (CTT) were taken with the help of a Cochet-Bonnet aesthesiometer (an instrument for measuring corneal sensitivity) for all participants before the lidocaine treatment.
- One randomly selected eye from each horse was treated with 0.2mL of 2% lidocaine gel and the other eye was treated with an identical volume of a viscous lubricant, serving as the control.
- The measurements of CTT value were recorded for both eyes at several different time intervals – 5, 10, 20, 30, 45, 60, 75 and 90 minutes post lidocaine gel application.
- The researchers also observed any local adverse effects caused due to application of the lidocaine gel.
Results and Findings
- The outcome of the research displayed that there was no significant difference (p>0.05) between the baseline CTT measurements of control eyes and those subsequently treated with lidocaine gel.
- Significant changes in corneal sensitivity were not observed in control eyes over time during the research process.
- On the other hand, a noticeable reduction in corneal sensitivity was observed post the application of lidocaine, with substantially lower CTT values than the control eyes from 5 to 75 minutes.
- The effects of corneal anaesthesia were at their peak and constant from 10 to 45 minutes after the application of the lidocaine gel, with CTT values ranging from 0.21 to 0.45cm.
- Corneal epithelial irregularities were noticed in three eyes that received the lidocaine treatment however, these irregularities resolved spontaneously within a day.
Conclusion
- The experiment concluded that a deep and long-lasting corneal anaesthesia can be achieved by applying 2% lidocaine gel to the equine eye, with only minimal changes in the corneal epithelium.
- This finding could be advantageous for performing minor eye surgeries on horses while they remain standing and sedated.
Cite This Article
APA
Regnier A, Berton I, Concordet D, Douet JY.
(2017).
Effect of topical application of 2% lidocaine gel on corneal sensitivity of clinically normal equine eyes.
Vet Anaesth Analg, 45(2), 158-164.
https://doi.org/10.1016/j.vaa.2017.08.008 Publication
Researcher Affiliations
- Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, Université Fédérale de Toulouse Midi-Pyrénées, Toulouse, France.
- Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, Université Fédérale de Toulouse Midi-Pyrénées, Toulouse, France.
- Department of Biological and Functional Sciences, Ecole Nationale Vétérinaire de Toulouse, Université Fédérale de Toulouse Midi-Pyrénées, Toulouse, France.
- Department of Clinical Sciences, Ecole Nationale Vétérinaire de Toulouse, Université Fédérale de Toulouse Midi-Pyrénées, Toulouse, France. Electronic address: jy.douet@envt.fr.
MeSH Terms
- Administration, Topical
- Anesthesia, Local / veterinary
- Anesthetics, Local / pharmacology
- Animals
- Cornea / drug effects
- Female
- Horses
- Lidocaine / pharmacology
- Male
- Prospective Studies
- Single-Blind Method
Citations
This article has been cited 1 times.- Ziaei P, Resnick JL, Stella N, DiLeo MV. Novel Combined Lidocaine/Povidone Iodine Delivery System for Preintravitreal Injection.. J Ocul Pharmacol Ther 2022 May;38(4):319-325.
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