Effect of treatment with a topical ophthalmic preparation of 1% nalbuphine solution on corneal sensitivity in clinically normal horses.
Abstract: To assess the effect of treatment with a topical ophthalmic preparation of 1.2% nalbuphine solution on corneal sensitivity in clinically normal horses. Methods: 8 horses. Methods: Baseline corneal touch threshold (CTT) was measured (defined as the mean filament length [mm] at which a consistent blink response was elicited) for both eyes of each horse by use of a Cochet-Bonnet aesthesiometer. Subsequently, 0.2 mL of 1.2% nalbuphine solution was instilled in 1 randomly selected eye of each horse, and 0.2 mL of artificial tears solution was instilled in the contralateral eye (control treatment). For all 8 horses, CTT of each eye was measured within 1 minute following nalbuphine or artificial tears administration and every 15 minutes thereafter for 60 minutes. For 5 of the 8 horses, CTT was also measured in both eyes at 120 minutes. Changes in CTT values from baseline over time were assessed, as were differences between treated and control eyes. Results: At any time point, corneal sensitivity following nalbuphine treatment did not differ significantly from control treatment findings. Mean CTTs for nalbuphine-treated and control eyes were 38.8 and 37.9 mm, respectively. In both groups, CTT was significantly lower than baseline value at 15, 45, 60, and 120 minutes. No tearing or redness developed in any eye treated with nalbuphine. Conclusions: Topical administration of ophthalmic 1% nalbuphine solution had no effect on corneal sensitivity in clinically normal horses. The topical ocular treatment was not associated with local irritation.
Publication Date: 2010-02-02 PubMed ID: 20113231DOI: 10.2460/ajvr.71.2.223Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research paper assesses how the application of 1.2% nalbuphine solution eye drops affects corneal sensitivity in healthy horses.
Methods and Procedure
- The study involved 8 horses. On each horse, the baseline sensitivity of the cornea, or Corneal Touch Threshold (CTT), was measured using a device called the Cochet-Bonnet aesthesiometer. This measurement was taken for both eyes.
- After baseline sensitivity was established, one eye of each horse was treated with 0.2 mL of 1.2% nalbuphine solution while the other eye was treated with 0.2 mL of artificial tears as a control.
- The CTT for both eyes of each horse was measured one minute after the administration of nalbuphine or artificial tears. This measurement process was repeated every 15 minutes for 60 minutes.
- For 5 of the 8 horses, the CTT was also measured two hours after the initial treatment.
- Changes in the CTT from baseline over the period were evaluated. Differences between the CTT for eyes treated with nalbuphine and the control eyes were also assessed.
Results
- The research found that the corneal sensitivity did not change significantly following the application of the nalbuphine solution compared to the control treatment. The average CTT for eyes treated with nalbuphine was 38.8mm, and the average CTT for the control eyes was 37.9mm.
- CTT for both groups was significantly lower than the baseline at 15, 45, 60, and 2 hours post-treatment.
- There was no observed eye redness or excessive tearing in any of the eyes treated with nalbuphine, indicating that the solution did not cause local irritation.
Conclusion
- The research concluded that the topical application of 1% nalbuphine solution does not affect corneal sensitivity in clinically healthy horses. Additionally, the treatment did not cause any local irritation.
This research contributes to our understanding of the impact of nalbuphine solution on corneal sensitivity and suggests that this method is safe for use in equine ophthalmic treatment.
Cite This Article
APA
Wotman KL, Utter ME.
(2010).
Effect of treatment with a topical ophthalmic preparation of 1% nalbuphine solution on corneal sensitivity in clinically normal horses.
Am J Vet Res, 71(2), 223-228.
https://doi.org/10.2460/ajvr.71.2.223 Publication
Researcher Affiliations
- New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA.
MeSH Terms
- Administration, Topical
- Animals
- Cornea / drug effects
- Female
- Horses
- Male
- Nalbuphine / administration & dosage
- Nalbuphine / pharmacology
Citations
This article has been cited 1 times.- Von Zup M, Lassaline M, Kass PH, Miller PE, Thomasy SM. Effects of 0.2% brimonidine and 0.2% brimonidine-0.5% timolol on intraocular pressure and pupil size in normal equine eyes. Equine Vet J 2017 Nov;49(6):810-814.
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