Effectiveness of fenbendazole against later 4th-stage Strongylus vulgaris in ponies.
Abstract: Twelve pony foals (reared worm-free) were inoculated with Strongylus vulgaris. Approximately 8 weeks later, 4 of the foals were given fenbendazole (10% suspension) at a dosage rate of 10 mg/kg of body weight daily for 5 days and 4 foals were given the suspension at a dosage rate of 50 mg/kg daily for 3 days; the remaining foals were given a placebo. All treatments were administered by stomach tube. Fenbendazole was 99.6 and 97.9% effective in the 2 treatment groups, respectively, in eliminating later 4th-stage S vulgaris larvae located near the origin of major intestinal arteries. On microscopic examination of the ileocolic artery from fenbendazole-treated foals, a few larval remnants were found beneath the tunica intima in small organized mural thrombi overgrown with endothelium. It would appear that larvae are rapidly destroyed after administration of fenbendazole. A pony foal reared on pasture and with arteriographic evidence of arteritis of the cranial mesenteric and ileocolic arteries was treated with fenbendazole (10% suspension) by stomach tube at a dosage rate of 50 mg/kg of body weight daily for 3 days. By arteriographic examination made 4 weeks later, there was evidence of regression of the lesion, and at necropsy done a week later, there was no arteritis or larvae in the lumen of those arteries.
Publication Date: 1983-12-01 PubMed ID: 6362499
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research investigates the efficacy of fenbendazole against the Strongylus vulgaris larvae in pony foals. The study reveals that fenbendazole effectively eradicates the larvae and contributes to arterial lesion regression.
Research Methodology
- The research was carried out on twelve worm-free pony foals that were purposefully infected with Strongylus vulgaris.
- Post a period of 8 weeks, two groups of foals were treated with fenbendazole, administered orally with different dosage rates—4 foals were given a daily dosage of 10 mg/kg of body weight for 5 days, and another group of 4 foals were given 50 mg/kg daily for 3 days.
- The remaining foals were given a placebo for comparison.
- The research also included observation of a pasture-reared pony foal with confirmed arteritis of the cranial mesenteric and ileocolic arteries, treated with a daily dose of 50 mg/kg of fenbendazole for three consecutive days.
Research Findings
- In the two experimental groups treated with fenbendazole, the drug effectiveness quotient was extremely high, i.e., 99.6% and 97.9%, in eliminating the Strongylus vulgaris larvae situated near the major intestinal arteries’ origin.
- Few larval remnants were found beneath the tunica intima in small organized mural thrombi overgrown with endothelium on the microscopic study of these fenbendazole-treated groups, suggesting that fenbendazole rapidly destroys the larvae.
- In the pasture-reared foal treated with fenbendazole, arteriographic examination post four weeks of treatment revealed regression of the arterial lesions, and no arteritis or larvae were found in the examined arteries during necropsy conducted a week later.
Conclusion
- The results strongly suggest the efficacy of fenbendazole in treating Strongylus vulgaris infection in pony foals.
- In addition to larvae eradication, it also helped in the reduction of arterial lesions caused due to the infection.
- This research could have significant implications on veterinary medicine concerning the treatment of Strongylus vulgaris infections in horses and ponies.
Cite This Article
APA
Slocombe JO, McCraw BM, Pennock PW, Baird JD.
(1983).
Effectiveness of fenbendazole against later 4th-stage Strongylus vulgaris in ponies.
Am J Vet Res, 44(12), 2285-2289.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Benzimidazoles / pharmacology
- Clinical Trials as Topic / veterinary
- Fenbendazole / pharmacology
- Fenbendazole / therapeutic use
- Horses
- Larva / drug effects
- Strongyle Infections, Equine / drug therapy
- Strongyle Infections, Equine / parasitology
- Strongyle Infections, Equine / pathology
- Strongyloidea / drug effects
Citations
This article has been cited 2 times.- Slocombe JO, McCraw BM. Evaluation of ivermectin against later fourth-stage Strongylus vulgaris in ponies at two and five weeks after treatment.. Can J Comp Med 1984 Oct;48(4):343-8.
- Slocombe JO, McCraw BM, Pennock PW, Ducharme N, Baird JD. Strongylus vulgaris in the tunica media of arteries of ponies and treatment with ivermectin.. Can J Vet Res 1987 Apr;51(2):232-5.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
