Effectiveness of ivermectin in the treatment of equine Parascaris equorum and Oxyuris equi infections.
Abstract: Fifteen horses harboring naturally acquired, patent Parascaris equorum and Oxyuris equi infections were equally allotted to 3 treatment groups given (1) injectable vehicle; (2) injectable ivermectin at the dose rate of 200 microgram/kg of body weight; and (3) injectable ivermectin at the rate of 300 microgram/kg. All treatments were given IM in the neck. All animals were killed 14 days after treatment and examined for the targeted nematodes. Regardless of dose rate, ivermectin proved 100% effective in the removal of adult O equi and P equorum infections. Levels of immature P equorum were decreased by 98.5% in both ivermectin-treated groups. Oxyuris equi 4th-stage larval injections were decreased by 95.7% and 99.9% by the 200 and 300 microgram/kg ivermectin treatments, respectively. Adverse reactions to the injections of drug were not seen.
Publication Date: PubMed ID: 6896611
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Summary
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This study finds that injectable ivermectin is extremely effective in treating horse infections caused by nematodes Parascaris equorum and Oxyuris equi, without any observable side effects.
Objective of the Study
- The aim of the study was to investigate the effectiveness of the antiparasitic drug ivermectin in the treatment of equine (horse) infections caused by nematodes Parascaris equorum and Oxyuris equi. These are common parasites in horses that can cause considerable health problems.
Research Methodology
- Fifteen horses naturally infected with these parasites were divided equally into three groups for treatment.
- The first group was given an injectable vehicle (possibly a placebo) as a control group. The second group was administered a dose of 200 micrograms per kilogram of body weight of injectable ivermectin. The third group received a dose of 300 micrograms per kilogram.
- All treatments were injected into the neck muscle (intramuscularly). The horses were monitored for 14 days after treatment.
Results of the Study
- Findings suggest the treatment was extremely successful. Both doses of ivermectin proved to be 100% effective in removing adult nematode infections.
- The number of immature P. equorum nematodes was reduced by 98.5% in both treatment groups. The quantities of the 4th stage larvae of O. equi were also substantially decreased—95.7% with the 200 microgram/kg ivermectin dose and 99.9% with the 300 microgram/kg dose.
- Most importantly, no adverse reactions to the drug injections were reported, making it a safe and effective treatment method.
Conclusions of the Study
- The study concludes the injectable ivermectin could be a highly effective and safe treatment for horse infections with P. equorum and O. equi. It suggests that a higher dose may be slightly more effective at treating larvae, but both doses are equally effective at treating adult nematodes.
Cite This Article
APA
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Effectiveness of ivermectin in the treatment of equine Parascaris equorum and Oxyuris equi infections.
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