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Effects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alveolar concentrations in horses.
Abstract: The aim of this investigation was to determine the isoflurane-sparing effect and impact on arterial blood pressure and anaesthetic recovery of a constant rate infusion of medetomidine-propofol in horses. In a prospective, crossover, randomised study, six healthy horses (mean ± SD age, 13.7 ± 7.7 years; weight, 433 ± 51 kg) were anaesthetised twice with isoflurane and were randomly assigned to receive one of two treatments on each occasion, at least 2 weeks apart. The first treatment was saline (CTL group) and the second a medetomidine-propofol infusion (MP group; 1.25 µg/kg/h medetomidine and 3 mg/kg/h propofol). The isoflurane minimum alveolar concentration (MAC) was determined and the reduction in anaesthetic requirements was calculated. Cardiopulmonary data were recorded at different intervals during the procedure and anaesthetic recovery was blindly assessed using three independent scales. The MAC in the MP group (0.43 ± 0.08%) was 65% lower than in the CTL group (1.23 ± 0.10%). The MP group had a higher mean arterial blood pressure and required less dobutamine than the CTL group. The recovery quality in both groups was considered fair or good and an improvement was observed using the Donaldson scale in the MP group. The administration of a medetomidine-propofol constant rate infusion reduced anaesthetic isoflurane requirements to a clinically significant extent and improved stability of arterial blood pressure together with a good quality recovery. This regime could be useful for providing balanced anaesthesia in horses.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication Date: 2014-08-25 PubMed ID: 25239299DOI: 10.1016/j.tvjl.2014.08.007Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research explores how a constant infusion of medetomidine-propofol can reduce the amount of isoflurane (an anesthetic) needed in horses, and effects it has on their blood pressure and recovery from anesthesia. It shows that this method can significantly lower the necessary amount of isoflurane while stabilizing arterial blood pressure and improving the recovery process, making it a feasible way to provide balanced anesthesia in horses.
Study design
- The study was executed on six healthy horses with a mean age of 13.7 years and a mean weight of 433 kg. It was a crossover, randomized design which means that each horse received two treatments at different times, with a pause of at least 2 weeks in between.
- The two treatments in question were a saline solution (Control, CTL) and a medetomidine-propofol infusion (MP). The horses were randomly assigned to receive one of these two treatments on each occasion.
Methodology
- The minimum alveolar concentration (MAC) of isoflurane (a measure of the potency of the anesthetic) was determined for both the CTL group and the MP group.
- Cardiopulmonary data were recorded at various points throughout the procedure.
- The recovery from anesthesia was reviewed using three separate scales, each assessment blind to the others.
Findings
- Results showed a 65% lower MAC in the MP group compared to the CTL group.
- Horses in the MP group had higher average arterial blood pressure and required less dobutamine (a drug used to treat heart failure and low blood pressure).
- The quality of recovery was evaluated as fair or good in both groups, with improvements noted in the MP group according to the Donaldson scale (a recovery assessment tool).
Conclusion
- The outcome of this study indicated that constant rate infusions of medetomidine-propofol can decrease the amount of isoflurane needed in horses, stabilizing arterial blood pressure and potentially improving recovery.
- This approach might be beneficial for providing balanced anesthesia in horses in a clinical setting.
Cite This Article
APA
Villalba M, Santiago I, Gómez de Segura IA.
(2014).
Effects of a constant rate infusion of medetomidine-propofol on isoflurane minimum alveolar concentrations in horses.
Vet J, 202(2), 329-333.
https://doi.org/10.1016/j.tvjl.2014.08.007 Publication
Researcher Affiliations
- Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
- Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
- Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain. Electronic address: iagsegura@vet.ucm.es.
MeSH Terms
- Adrenergic alpha-2 Receptor Agonists / administration & dosage
- Adrenergic alpha-2 Receptor Agonists / adverse effects
- Anesthesia Recovery Period
- Anesthetics, Inhalation / administration & dosage
- Anesthetics, Inhalation / pharmacology
- Anesthetics, Intravenous / administration & dosage
- Anesthetics, Intravenous / adverse effects
- Animals
- Cardiovascular System / drug effects
- Cross-Over Studies
- Drug Combinations
- Female
- Horses / metabolism
- Isoflurane / administration & dosage
- Isoflurane / pharmacology
- Medetomidine / administration & dosage
- Medetomidine / adverse effects
- Propofol / administration & dosage
- Propofol / adverse effects
- Prospective Studies
- Pulmonary Alveoli / drug effects
Citations
This article has been cited 3 times.- Murillo C, Weng HY, Weil AB, Kreuzer M, Ko JC. Perioperative Brain Function Monitoring with Electroencephalography in Horses Anesthetized with Multimodal Balanced Anesthetic Protocol Subjected to Surgeries. Animals (Basel) 2022 Oct 20;12(20).
- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
- Tokushige H, Okano A, Arima D, Ito H, Kambayashi Y, Minamijima Y, Ohta M. Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Acta Vet Scand 2018 Nov 5;60(1):71.
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