Effects of a single dose of enrofloxacin on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation.
Abstract: To evaluate effects of a single dose of enrofloxacin (5 mg/kg, IV) on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation. Methods: 32 healthy Thoroughbreds. Methods: All horses received interferon-α (0.5 U/kg, sublingually, q 24 h) as an immunologic stimulant for 2 days before transportation and on the day of transportation. Horses were randomly assigned to receive enrofloxacin (5 mg/kg, IV, once; enrofloxacin group) or saline (0.9% NaCl) solution (50 mL, IV, once; control group) ≤ 1 hour before being transported 1,210 km via commercial vans (duration, approx 26 hours). Before and after transportation, clinical examination, measurement of temperature per rectum, and hematologic analysis were performed for all horses; a tracheobronchial aspirate was collected for neutrophil quantification in 12 horses (6/group). Horses received antimicrobial treatment after transportation if deemed necessary by the attending clinician. Results: No adverse effects were associated with treatment. After transportation, WBC count and serum amyloid A concentration in peripheral blood samples and neutrophil counts in tracheobronchial aspirates were significantly lower in horses of the enrofloxacin group than in untreated control horses. Fever (rectal temperature, ≥ 38.5°C) after transportation was detected in 3 of 16 enrofloxacin group horses and 9 of 16 control horses; additional antimicrobial treatment was required in 2 horses in the enrofloxacin group and 7 horses in the control group. Conclusions: In horses premedicated with interferon-α, enrofloxacin appeared to provide better protection against fever and lower respiratory tract inflammation than did saline solution.
Publication Date: 2012-06-29 PubMed ID: 22738047DOI: 10.2460/ajvr.73.7.968Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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This study assesses how a single dose of an antibiotic, enrofloxacin, affects body temperature and the tracheobronchial neutrophil count in healthy Thoroughbreds. The horses were pre-medicated with an immune stimulant, interferon-α, and were then subject to long-distance travel.
Research Methods
- The study involved 32 healthy Thoroughbreds all of whom received interferon-α as an immune stimulant for two days before transportation and on the day of transportation.
- Horses were randomly allocated to receive either a dose of enrofloxacin or a saline solution less than one hour before being transported 1,210 km via commercial vans. The journey lasted approximately 26 hours.
- Before and after transport, all horses underwent a clinical examination, body temperature measurement, and hematologic analysis. A tracheobronchial aspirate was collected from 12 of the horses for neutrophil quantification.
- Post transportation, horses were given antimicrobial treatment if necessary as determined by the vet.
Research Findings
- No adverse effects were linked with the treatment.
- After transport, the white blood cell (WBC) count, serum amyloid A concentration in the peripheral blood samples, and neutrophil counts in the tracheobronchial aspirates of the horses that received enrofloxacin were significantly lower than in untreated control horses.
- Fever after transportation (a rectal temperature of ≥ 38.5°C) was found in 3 of 16 enrofloxacin-treated horses as compared to 9 of the 16 control horses.
- Additional antimicrobial treatment was necessary in 2 horses from the enrofloxacin group and 7 from the control group.
Conclusions
- The researchers concluded that enrofloxacin administered to horses pre-medicated with interferon-α provided better protection against fever and lower respiratory tract inflammation than the saline solution did.
Cite This Article
APA
Tsuchiya T, Hobo S, Endo Y, Narita S, Sakamoto K.
(2012).
Effects of a single dose of enrofloxacin on body temperature and tracheobronchial neutrophil count in healthy Thoroughbreds premedicated with interferon-α and undergoing long-distance transportation.
Am J Vet Res, 73(7), 968-972.
https://doi.org/10.2460/ajvr.73.7.968 Publication
Researcher Affiliations
- Hidaka Training and Research Center, Japan Racing Association, 535-13, Nishicha, Urakawa-chou, Urakawa-gun, Hokkaido 057-0171, Japan. gagner.prix.de.l.arc.de.triomphe@gmail.com
MeSH Terms
- Animals
- Anti-Infective Agents / administration & dosage
- Body Temperature / drug effects
- Enrofloxacin
- Female
- Fluoroquinolones / administration & dosage
- Horses / blood
- Horses / physiology
- Interferon-alpha / administration & dosage
- Leukocyte Count / veterinary
- Male
- Neutrophils / cytology
- Neutrophils / drug effects
- Respiratory System / cytology
- Respiratory System / drug effects
- Serum Amyloid A Protein / metabolism
- Transportation
Citations
This article has been cited 5 times.- Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
- Endo Y, Ishikawa Y, Arima D, Mae N, Iwamoto Y, Korosue K, Tsuzuki N, Hobo S. Effects of pre-shipping enrofloxacin administration on fever and blood properties in adult Thoroughbred racehorses transported a long distance.. J Vet Med Sci 2017 Mar 18;79(3):464-466.
- Endo Y, Tsuchiya T, Omura T, Nakai K, Korosue K, Ishimaru M, Ishikawa Y, Hobo S. Effects of pre-shipping marbofloxacin administration on fever and blood properties in healthy Thoroughbreds transported a long distance.. J Vet Med Sci 2015 Jan;77(1):75-9.
- Endo Y, Hobo S, Korosue K, Ootsuka K, Kitauchi A, Kikkawa R, Hidaka Y, Hagio M, Tsuzuki N. Effects of low-dose G-CSF formulation on hematology in healthy horses after long-distance transportation.. J Vet Med Sci 2015 Apr;77(4):507-9.
- Endo Y, Tsuchiya T, Akiyama K, Takebe N, Nakai K, Korosue K, Ishimaru M, Tsuzuki N, Hobo S. Comparison of the Occurrence of Transportation-associated Fever in 2 Years Old Thoroughbreds before and after Introduction of Prophylactic Marbofloxacin Administration.. J Equine Sci 2014;25(4):79-81.
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