Effects of adding butorphanol to a balanced anaesthesia protocol during arthroscopic surgery in horses.
Abstract: Three groups of horses scheduled for arthroscopic surgery were premedicated with 0.025 mg/kg acepromazine, 88 microg/kg romifidine and 25 mg/kg guaifenesin, and anaesthesia was induced with 2.2 mg/kg ketamine. In group 1 (14 horses), anaesthesia was maintained by halothane vaporised in oxygen, with supplementary doses of 20 microg/kg romifidine and 0.5 mg/kg ketamine every 20 minutes. The 17 horses in group 2 were maintained as for group 1; however, an additional dose of 0.05 mg/kg butorphanol was administered before the first incision. The 14 horses in group 3 were maintained as for group 2, except that the dose of romifidine was halved to 10 microg/kg. The mean (sd) dose of vaporised halothane (6.5 [1.1], 4.8 [1.3] and 4.8 [1.3] microl/kg/minute, for groups 1, 2 and 3, respectively), vaporiser dial setting (2.3 [0.2],1.6 [0.4] and 1.3 [0.1] per cent) and dose of dobutamine administered to correct episodes of hypotension (0.16 [0.08], 0.07 [0.09] and 0.0 [0.0] microg/kg/minute) were all significantly lower in groups 2 and 3 than in group 1. Mean arterial blood pressure was significantly higher in groups 2 and 3 than in group 1 (71 [3], 74 [5] and 80 [5] mmHg, for groups 1, 2 and 3, respectively).
Publication Date: 2010-03-17 PubMed ID: 20228366DOI: 10.1136/vr.b4799Google Scholar: Lookup
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Summary
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This abstract reports on a study examining the impact of using butorphanol in a balanced anaesthesia protocol for horses undergoing arthroscopic surgery. The research demonstrated that adding butorphanol decreased the required dose of halothane and dobutamine while maintaining or increasing mean arterial blood pressure.
Research Objectives and Methodology
- The study’s primary aim was to ascertain the influence of adding butorphanol to a balanced anaesthesia protocol in horses undergoing arthroscopic surgery. This was evaluated by comparing three groups of horses given slightly different anesthesia regimes.
- The three groups were pre-medicated with the same substances: acepromazine, romifidine, and guaifenesin. Anaesthesia was induced with ketamine.
- Group 1’s anesthesia was maintained with halothane vaporized in oxygen and supplementary doses of romifidine and ketamine delivered every 20 minutes.
- In Group 2, an additional dose of butorphanol was given before the first incision.
- Group 3’s anesthesia was maintained in a manner similar to Group 2, but the romifidine dose was halved.
Findings of the Research
- The findings indicated significant differences between the groups. The mean dose of vaporized halothane, the vaporiser dial setting, and the dose of dobutamine (administered in response to episodes of hypotension or low blood pressure) were all lower in the groups 2 and 3 as compared to group 1. This indicates that the addition of butorphanol reduced the amount of other anaesthetic and blood pressure support required.
- The mean arterial blood pressure was significantly higher in groups 2 and 3 than in group 1. When given butorphanol (as in groups 2 and 3), the horses maintained a stronger blood pressure compared to Group 1 where butorphanol was not used.
- These findings suggest a positive impact of adding butorphanol to the anaesthesia regime for arthroscopic surgery in horses, as it minimized the need for anaesthetic agents and increased blood pressure stability.
Implication of the Results
- The results suggest that incorporating butorphanol in the anesthesia protocol can be beneficial in maintaining stable blood pressure and may also reduce the required dosage of other anaesthetics, potentially lowering the risk of their side effects.
- Still, additional research is necessary to confirm these findings and further explore the implications for equine anesthesia practice.
Cite This Article
APA
Caure S, Cousty M, Tricaud C.
(2010).
Effects of adding butorphanol to a balanced anaesthesia protocol during arthroscopic surgery in horses.
Vet Rec, 166(11), 324-328.
https://doi.org/10.1136/vr.b4799 Publication
Researcher Affiliations
- Clinique Equine de Livet, Cour Samson, 14140 Saint Michel de Livet, France.
MeSH Terms
- Acepromazine / administration & dosage
- Anesthesia / veterinary
- Anesthesia Recovery Period
- Anesthetics, Dissociative / administration & dosage
- Anesthetics, Inhalation / administration & dosage
- Animals
- Arthroscopy / veterinary
- Blood Pressure / drug effects
- Blood Pressure / physiology
- Butorphanol / administration & dosage
- Dose-Response Relationship, Drug
- Guaifenesin / administration & dosage
- Halothane / administration & dosage
- Horse Diseases / chemically induced
- Horse Diseases / prevention & control
- Horse Diseases / surgery
- Horses / physiology
- Hypotension / chemically induced
- Hypotension / prevention & control
- Hypotension / veterinary
- Imidazoles / adverse effects
- Ketamine / administration & dosage
- Narcotics / administration & dosage
Citations
This article has been cited 1 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
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