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Home / Equine Research Bank / Can Vet J / Effects of administration of a synthetic low molecular weigh...
The Canadian veterinary journal = La revue veterinaire canadienne2015; 56(10); 1069-1074;

Effects of administration of a synthetic low molecular weight/low molar substitution hydroxyethyl starch solution in healthy neonatal foals.

Abstract: This study compared the effects of IV administration of isotonic fluid therapy and colloidal fluid therapy in healthy neonatal foals. Fifteen healthy neonatal foals were used in a randomized blinded prospective clinical study. Foals were randomly assigned to receive a bolus of 20 mL/kg of tetrastarch (TES) or balanced crystalloid solution. Vital parameters, colloid osmotic pressure (COP), and various clinicopathologic variables were assessed prior to infusion and at various time points up to 120 h after infusion. The treatment group (TES) had a significant increase in both COP and percentage increase in COP at 1 and 3 h. The COP was significantly lower than baseline at 3 h in the control group. No significant changes were observed in coagulation parameters in either group. Tetrastarch was effective in increasing COP for 3 h after infusion and had no notable adverse clinical effects in this group of healthy foals. Further studies are warranted regarding optimal dosing and effects in clinically ill foals. Cette étude a comparé les effets de l’administration IV d’une fluidothérapie isotonique et d’une fluidothérapie colloïdale chez des poulains néonataux en santé. Quinze poulains néonataux ont été utilisés dans une étude clinique prospective randomisée. Les poulains ont été assignés au hasard pour recevoir un bolus de 20 mL/kg de tétra-amidon (TEA) ou d’une solution cristalloïde équilibrée. Les paramètres vitaux, la pression osmotique colloïdale (POC) et diverses variables clinicopathologiques ont été évalués avant l’infusion et à divers moments jusqu’à 120 heures après l’infusion. Le groupe de traitement (TEA) a subi une hausse importante de la POC et une augmentation du pourcentage de POC à 1 et 3 heures dans le groupe témoin. Aucun changement significatif n’a été observé dans les paramètres de coagulation des deux groupes. Le tétra-amidon a été efficace pour l’augmentation de la POC pendant 3 heures après l’infusion et il n’a pas eu d’effets cliniques négatifs notables dans ce groupe de poulains en santé. De nouvelles études sont justifiées concernant le dosage optimal et les effets chez les poulains cliniquement malades.(Traduit par Isabelle Vallières).
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Publication Date: 2015-10-21 PubMed ID: 26483583PubMed Central: PMC4572826
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the effects of IV administration of isotonic fluid therapy (tetrastarch) versus balanced crystalloid solution on colloid osmotic pressure (COP) and clinicopathologic variables within healthy neonatal foals, finding tetrastarch to be effective and without notable adverse effects.

Study Design and Subjects

  • The study is a randomized, blinded, and prospective clinical study using 15 healthy neonatal foals as research subjects. The foals were divided into two groups at random and were assigned to receive an IV infusion of either tetrastarch or a balanced crystalloid solution.

Experimental Procedure

  • Each foal received a bolus of 20 mL/kg of the respective substance.
  • Various vital parameters and clinicopathologic variables were evaluated before the infusion and at different times, up to 120 hours after the infusion to measure any changes.

Outcome and Results

  • The tetrastarch group experienced a significant increase in colloid osmotic pressure (COP) at the first and third hours following infusion.
  • The control group, which received the balanced crystalloid solution, saw a significant decrease in COP from baseline at the third hour.
  • No significant changes were noticed in the coagulation parameters in either group of foals.

Final Conclusions

  • Tetrastarch was found to be effective in increasing COP for 3 hours post-infusion, suggesting that it was well tolerated by the foals as no negative clinical effects were reported.
  • Despite these positive findings, more research is suggested to determine optimal dosing and effects in clinically ill foals.

Cite This Article

APA
Hepworth-Warren KL, Wong DM, Hay-Kraus BL, Wang C, Sun Y. (2015). Effects of administration of a synthetic low molecular weight/low molar substitution hydroxyethyl starch solution in healthy neonatal foals. Can Vet J, 56(10), 1069-1074.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 56
Issue: 10
Pages: 1069-1074

Researcher Affiliations

Hepworth-Warren, Kate L
  • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Wong, David M
  • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Hay-Kraus, Bonnie L
  • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Wang, Chong
  • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.
Sun, Yaxuan
  • Department of Veterinary Clinical Sciences (Hepworth-Warren, Wong, Hay-Kraus) and Veterinary Diagnostic and Production Medicine (Wang, Sun), College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA.

MeSH Terms

  • Animals
  • Blood Coagulation / drug effects
  • Colloids
  • Erythrocyte Count / veterinary
  • Female
  • Heart Rate / drug effects
  • Hematocrit / veterinary
  • Horses / blood
  • Hydroxyethyl Starch Derivatives / pharmacology
  • Isotonic Solutions / pharmacology
  • Lactic Acid / blood
  • Leukocyte Count / veterinary
  • Male
  • Osmotic Pressure
  • Respiration / drug effects

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Citations

This article has been cited 1 times.
  1. Boyd CJ, Brainard BM, Smart L. Intravenous Fluid Administration and the Coagulation System.. Front Vet Sci 2021;8:662504.
    doi: 10.3389/fvets.2021.662504pubmed: 33937383google scholar: lookup
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