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Effects of continuous intra-articular infusion of gentamicin on synovial membrane and articular cartilage in the tarsocrural joint of horses.
Abstract: To determine the effects of a continuous intra-articular infusion of gentamicin on the synovial membrane and articular cartilage in the tarsocrural joint of horses. Methods: 6 healthy adult horses. Methods: A balloon infusion system attached to a catheter placed in the plantarolateral pouch of both tarsocrural joints in each horse was used for continuous gentamicin solution (GM) or balanced electrolyte solution (BES) delivery for 5 days. Cartilage and synovial membrane specimens were collected on day 5 from 3 horses and on day 14 from the remaining 3 horses. Both infused joints from each horse were assessed, using gross evaluation and histologic scoring systems. Results: Significant differences in the histologic scores of synovial membrane specimens between the GM- and BES-treated joints at either 5 or 14 days were not observed. Safranin-O-fast green staining scores were similar between cartilage specimens from GM- and BES-treated joints. Although the synovial membrane histologic scores and safranin-O-fast green staining scores improved from day 5 to 14, the changes in scores were not significant. Loss of synovial intimal cells from villi was found more commonly in sections of synovial membrane from GM-treated joints, compared with BES-treated joints. Conclusions: Continuous infusion of GM into the tarsocrural joint of horses does not have significant effects on histologic scores of articular cartilage or synovial membrane, compared with those infused with BES. Continuous infusion of GM into the tarsocrural joint of horses for 5 days is an acceptable method for the treatment of septic arthritis.
Publication Date: 2002-05-16 PubMed ID: 12013469DOI: 10.2460/ajvr.2002.63.683Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research is about examining the effects of continuously infusing a drug called gentamicin into a joint in the horse’s leg, specifically looking at its impacts on the joint’s membrane and cartilage. The study found that this method does not significantly affect these tissues compared to a control treatment, suggesting that it could be a suitable treatment for joint infections in horses.
Methods
- The study was conducted on 6 healthy adult horses. They used a balloon infusion system fitted with a catheter, which was placed in a specific pouch of the joint in each horse’s leg.
- The horse’s legs were either given a continuous infusion of gentamicin solution (GM) or a balanced electrolyte solution (BES) as a control for 5 days.
- The samples of cartilage and synovial membrane (joint tissue) were collected on the fifth day from half the horses and on the 14th day from the remaining horses. The samples were then examined and scored using specific evaluation systems.
Results
- The study found no significant differences in the tissue scores between joints treated with the gentamicin solution and those treated with the control solution, either at 5 or 14 days. This was the case for both the joint tissue and the cartilage.
- However, loss of certain cells from the tissue was more commonly observed in the gentamicin-treated joints compared to the control joints.
- Interestingly, there was an improvement in scores from day 5 to day 14, but this change was not deemed statistically significant.
Conclusions
- The main takeaway from the study is that continuous infusion of gentamicin into the horse joint does not significantly affect the health of the cartilage or synovial membrane compared to a control treatment.
- These findings support the use of this method for treating septic arthritis (a type of joint infection) in horses, given its lack of significant adverse effects on the joint tissues.
Cite This Article
APA
Lescun TB, Adams SB, Wu CC, Bill RP, Van Sickle DC.
(2002).
Effects of continuous intra-articular infusion of gentamicin on synovial membrane and articular cartilage in the tarsocrural joint of horses.
Am J Vet Res, 63(5), 683-687.
https://doi.org/10.2460/ajvr.2002.63.683 Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47906, USA.
MeSH Terms
- Animals
- Anti-Bacterial Agents / administration & dosage
- Anti-Bacterial Agents / pharmacology
- Cartilage, Articular / drug effects
- Cartilage, Articular / metabolism
- Female
- Gentamicins / administration & dosage
- Gentamicins / pharmacology
- Glycosaminoglycans / metabolism
- Histocytochemistry / veterinary
- Horses / metabolism
- Horses / physiology
- Male
- Phenazines / chemistry
- Synovial Membrane / drug effects
- Synovial Membrane / metabolism
- Tarsus, Animal / drug effects
- Tarsus, Animal / metabolism
Citations
This article has been cited 4 times.- Pezzanite L, Chow L, Hendrickson D, Gustafson DL, Russell Moore A, Stoneback J, Griffenhagen GM, Piquini G, Phillips J, Lunghofer P, Dow S, Goodrich LR. Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity. Front Vet Sci 2021;8:676774.
- Pezzanite L, Chow L, Piquini G, Griffenhagen G, Ramirez D, Dow S, Goodrich L. Use of in vitro assays to identify antibiotics that are cytotoxic to normal equine chondrocytes and synovial cells. Equine Vet J 2021 May;53(3):579-589.
- Yazdi H, Yousof Gomrokchi A, Nazarian A, Lechtig A, Hanna P, Ghorbanhoseini M. The Effect of Gentamycin in the Irrigating Solution to Prevent Joint Infection after Anterior Cruciate Ligament (ACL) Reconstruction. Arch Bone Jt Surg 2019 Jan;7(1):67-74.
- Post HK, Blankespoor MG, Ierulli VK, Morey TD, Schroeppel JP, Mulcahey MK, Vopat BG, Vopat ML. Review of Intra-Articular Use of Antibiotics and Antiseptic Irrigation and Their Systematic Association with Chondrolysis. Kans J Med 2023;16(3):272-276.
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