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Journal of veterinary pharmacology and therapeutics2020; 43(5); 470-476; doi: 10.1111/jvp.12869

Effects of dobutamine on cardiovascular function and oxygen delivery in standing horses.

Abstract: Dobutamine is routinely used to improve cardiovascular function in anaesthetized horses. However, dobutamine in conscious horses is insufficiently investigated. Ten research horses that were already instrumented for a preceding trial were included into the study. Cardiovascular variables were recorded and blood samples taken after instrumentation (Baseline), before starting dobutamine and after 10 min of dobutamine infusion (2 µg kg  min ). A significant increase in systemic blood pressure, mean pulmonary artery pressure and right atrial pressure, and a decrease in heart rate were observed with dobutamine compared with baseline measurements. Arterial and mixed venous haemoglobin and oxygen content, as well as mixed venous partial pressure of oxygen increased. No significant changes in cardiac output, stroke volume, systemic vascular resistance, arterial partial pressure of oxygen, or oxygen consumption, delivery and extraction ratio were detected. Concluding, dobutamine increased systemic blood pressure without detectable changes in stroke volume, cardiac output or systemic vascular resistance in conscious horses.
© 2020 John Wiley & Sons Ltd.
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Publication Date: 2020-04-25 PubMed ID: 32333680DOI: 10.1111/jvp.12869Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reveals that the application of dobutamine, a drug often used in horses under anesthesia to regulate cardiovascular function, results in increased systemic blood pressure and oxygen content in conscious horses, without impacting stroke volume, cardiac output, or systemic vascular resistance.

Research Methodology and Study Design

  • The research was done on ten horses that had already been instrumented for a previous trial. The researchers tested the impact of dobutamine on various cardiovascular variables in these conscious horses.
  • Measurements were taken at three points for each horse: after instrumentation (Baseline), before beginning dobutamine administration, and after ten minutes of infusing dobutamine.

Findings and Observations

  • Initiation of dobutamine in these horses led to a significant increase in systemic blood pressure, mean pulmonary artery pressure, and right atrial pressure. Remarkably, heart rate decreased after dobutamine administration compared to baseline readings.
  • Arterial and mixed venous hemoglobin and oxygen contents also increased, along with a rise in mixed venous partial pressure of oxygen.
  • On the other hand, no significant changes were detected in other core cardiovascular factors such as cardiac output, stroke volume, systemic vascular resistance, arterial partial pressure of oxygen, or oxygen consumption, delivery, and extraction ratio after dobutamine administration.

Conclusion

  • The research findings suggest that the administration of dobutamine to conscious horses causes an increase in systemic blood pressure. Consumption and delivery of oxygen also inclined without showing any notable impact on the stroke volume, cardiac output, or systemic vascular resistance.
  • These results might be used to adjust dobutamine usage in not only anesthetized horses but also awake ones, popularly in the cases of equine athletes where blood pressure management becomes crucial during their high endurance performances.

Cite This Article

APA
Meier M, Bettschart-Wolfensberger R, Schwarzwald CC, Portier K, Gysler A, Ringer SK. (2020). Effects of dobutamine on cardiovascular function and oxygen delivery in standing horses. J Vet Pharmacol Ther, 43(5), 470-476. https://doi.org/10.1111/jvp.12869

Publication

Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 43
Issue: 5
Pages: 470-476

Researcher Affiliations

Meier, Merit
  • Department of Clinical Diagnostics and Services, Anaesthesiology Section, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Bettschart-Wolfensberger, Regula
  • Department of Clinical Diagnostics and Services, Anaesthesiology Section, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Schwarzwald, Colin Claudio
  • Equine Department, Clinic for Equine Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Portier, Karine
  • VetAgro Sup, Service d'anesthésiologie, Université de Lyon, Marcy l'Etoile, France.
  • CarMeN laboratory, INSERM, INRA, INSA-Lyon, Université Claude Bernard Lyon1, Université de Lyon, Villeurbanne, France.
Gysler, Annette
  • Department of Clinical Diagnostics and Services, Anaesthesiology Section, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Ringer, Simone Katja
  • Department of Clinical Diagnostics and Services, Anaesthesiology Section, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
  • VetAgro Sup, Service d'anesthésiologie, Université de Lyon, Marcy l'Etoile, France.

MeSH Terms

  • Animals
  • Cardiotonic Agents / pharmacology
  • Cardiovascular Physiological Phenomena / drug effects
  • Dobutamine / pharmacology
  • Female
  • Horses / physiology
  • Male
  • Oxygen Consumption / drug effects

Grant Funding

  • Forschungskredit of the University of Zurich / Forschungskredit of the University of Zurich
  • No number available / Stiftung Pro Pferd

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This article includes 17 references
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Citations

This article has been cited 4 times.
  1. Hopster K, Hurcombe SDA. Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in Healthy Standing Horses. Front Vet Sci 2021;8:701339.
    doi: 10.3389/fvets.2021.701339pubmed: 34414227google scholar: lookup
  2. Gorenberg EB, Slack J, Stefanovski D, Theiss D, Hopster K. Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane-anaesthetised horses. Equine Vet J 2025 Nov;57(6):1677-1689.
    doi: 10.1111/evj.14488pubmed: 40052197google scholar: lookup
  3. van Galen G, Divers TJ, Savage V, Schott HC 2nd, Siwinska N. ECEIM consensus statement on equine kidney disease. J Vet Intern Med 2024 Jul-Aug;38(4):2008-2025.
    doi: 10.1111/jvim.17101pubmed: 38801172google scholar: lookup
  4. Dufourni A, Buschmann E, Vernemmen I, Van Steenkiste G, van Loon G, Decloedt A. Effect of physiological and pharmacological stress on heart rate, blood pressure, and echocardiographic measurements in healthy Warmblood horses. J Vet Intern Med 2024 Jan-Feb;38(1):398-410.
    doi: 10.1111/jvim.16967pubmed: 38174810google scholar: lookup
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