Effects of fenoldopam mesylate on systemic hemodynamics and indices of renal function in normotensive neonatal foals.
Abstract: Fenoldopam mesylate, a dopamine-1 receptor agonist, has dose- and species-dependent effects on hemodynamics and renal function. The effects of this drug in normotensive neonatal foals have not been reported. Objective: Two doses of fenoldopam would result in distinct changes in the systemic circulation, urine output, and creatinine clearance of neonatal foals. Methods: Six Thoroughbred foals. Methods: Each foal received 2 dosages of fenoldopam (low dose, 0.04 microg/kg/min; high dose, 0.4 microg/kg/min) and a control administration of saline, in a masked, placebo-controlled study. Results: High-dosage fenoldopam had no effect on renal function but caused a significant increase in heart rate and decrease in mean, systolic and diastolic arterial blood pressure compared with saline. Low-dosage fenoldopam had no effects on systemic hemodynamics, significantly increased urine output, and had no significant effect on creatinine clearance or the fractional excretions of sodium, potassium, or chloride compared with saline. Conclusions: These data suggest that high-dosage fenoldopam increases heart rate, decreases arterial blood pressure, and has no significant effects on renal function, whereas low-dosage fenoldopam has no significant effects on systemic hemodynamics while increasing urine output. This contrast is unique to this species and warrants further investigation.
Publication Date: 2006-06-01 PubMed ID: 16734095DOI: 10.1892/0891-6640(2006)20[595:eofmos]2.0.co;2Google Scholar: Lookup
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- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research paper examines and compares the effects of both low and high dosage fenoldopam mesylate, a dopamine-1 receptor agonist, on systemic circulation, urine output, and creatinine clearance of healthy newborn foals. The study found that while high dosage fenoldopam altered heart rate and blood pressure with no significant impact on renal function, low dosage fenoldopam increased urine output without affecting systemic hemodynamics.
Research Goal
- The main objective of this study was to analyze how two different dosages of fenoldopam, a dopamine receptor agonist, would affect the systemic circulation, urine output, and the clearance of creatinine in healthy neonatal foals.
Methodology
- The study involved six Thoroughbred foals which were given two doses of fenoldopam (a lower dose of 0.04 microg/kg/min and a higher dose of 0.4 microg/kg/min) and a saline control, in a controlled, blind test.
Results
- The research found that high-dosage fenoldopam had no noticeable effect on the renal function of the foals. However, it caused a significant increase in heart rate and a decrease in the mean, systolic, and diastolic arterial blood pressure compared to the control.
- On the other hand, low-dosage fenoldopam had no significant effects on the systemic circulation of the foals but resulted in a notable increase in urine output. There were no significant effects on creatinine clearance or the fractional excretions of sodium, potassium, or chloride compared with the control.
Conclusions
- The researchers concluded that high-dosage fenoldopam had effects on the cardiovascular system – increasing heart rate and decreasing arterial blood pressure – but had no significant impacts on renal functionality.
- In contrast, low-dosage fenoldopam increased urine output without affecting the systemic circulation. The cause of this difference, which appears to be unique to neonatal foals, merits further investigation.
Cite This Article
APA
Hollis AR, Ousey JC, Palmer L, Stoneham SJ, Corley KT.
(2006).
Effects of fenoldopam mesylate on systemic hemodynamics and indices of renal function in normotensive neonatal foals.
J Vet Intern Med, 20(3), 595-600.
https://doi.org/10.1892/0891-6640(2006)20[595:eofmos]2.0.co;2 Publication
Researcher Affiliations
- Royal Veterinary College, London, UK.
MeSH Terms
- Animals
- Animals, Newborn
- Antihypertensive Agents / administration & dosage
- Antihypertensive Agents / blood
- Antihypertensive Agents / pharmacokinetics
- Antihypertensive Agents / pharmacology
- Antihypertensive Agents / urine
- Creatinine / blood
- Electrocardiography / veterinary
- Female
- Fenoldopam / administration & dosage
- Fenoldopam / blood
- Fenoldopam / pharmacokinetics
- Fenoldopam / pharmacology
- Fenoldopam / urine
- Hemodynamics / drug effects
- Horses / metabolism
- Horses / physiology
- Infusions, Intravenous / veterinary
- Kidney / drug effects
- Kidney / physiology
- Kidney Function Tests / veterinary
- Male
Citations
This article has been cited 2 times.- Bloom CA, Labato MA, Hazarika S, Court MH. Preliminary pharmacokinetics and cardiovascular effects of fenoldopam continuous rate infusion in six healthy dogs. J Vet Pharmacol Ther 2012 Jun;35(3):224-30.
- van Galen G, Divers TJ, Savage V, Schott HC 2nd, Siwinska N. ECEIM consensus statement on equine kidney disease. J Vet Intern Med 2024 Jul-Aug;38(4):2008-2025.
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