Effects of intraarticular corticosteroid and sodium hyaluronate injections on synovial fluid production and synovial fluid content of sodium hyaluronate and proteoglycans in normal equine joints.
Abstract: Hyaluronate and cartilage proteoglycan fragments in synovial fluid from normal equine joints were determined after repeated intraarticular injections of beta-methasone, methylprednisolone, hyaluronate, saline and a combination of beta-methasone + hyaluronate and methylprednisolone + hyaluronate. The experimental intraarticular treatments were given at the beginning of the study and after one and two weeks. Synovial samples were obtained at the onset of the study and after 1, 2, 3, 4, 6, and 8 weeks. The synovial volume was determined and showed no significant changes after the repeated arthrocenteses and the experimental treatments. Corticosteroid injections resulted in increased levels of hyaluronate in the synovial fluid which indicated a stimulatory effect on the synoviocytes to produce hyaluronate. The corticosteroids also resulted in high levels (up to 20 times the initial level) of proteoglycans which indicated joint cartilage degradation. A combined injection of corticosteroids and high molecular weight hyaluronate reduced proteoglycan breakdown which indicated a protective effect of hyaluronate on the articular cartilage.
Publication Date: 1993-02-01 PubMed ID: 8451900DOI: 10.1111/j.1439-0442.1993.tb00595.xGoogle Scholar: Lookup
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- Journal Article
- Arthrocentesis
- Articular Cartilage
- Cartilage
- Clinical Study
- Corticosteroids
- Degenerative Joint Disease
- Disease Treatment
- Equine Health
- Experimental Methods
- Horses
- Inflammation
- Intra-Articular Injection
- Joint Health
- Pharmacology
- Physiology
- Proteoglycans
- Sodium Hyaluronate
- Synovial Fluid
- Veterinary Care
- Veterinary Medicine
Summary
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The research study investigates the impact of different intra-articular injections on synovial fluid production and its contents such as sodium hyaluronate and proteoglycans in normal horse joints. It found that corticosteroid injections increase hyaluronate levels, suggesting these shots stimulate synoviocytes to produce more hyaluronate. Also, corticosteroids cause high levels of proteoglycans, implying joint cartilage degradation. However, combining corticosteroids and hyaluronate appears to reduce proteoglycan breakdown, suggesting a protective effect of hyaluronate on the joint cartilage.
Experiment Procedure
- The study involved administering repeated intra-articular injections containing beta-methasone, methylprednisolone, hyaluronate, saline, and combinations of beta-methasone + hyaluronate and methylprednisolone + hyaluronate in normal horse joints.
- This was done at the beginning of the study and after one and two weeks.
- Synovial samples were collected at the start of the study, and after 1, 2, 3, 4, 6, and 8 weeks.
Findings
- The study found no significant changes in the synovial volume after the repeated arthrocenteses and the experimental treatments.
- Corticosteroid injections increased levels of hyaluronate in the synovial fluid. This suggests a stimulatory effect on the synoviocytes to produce more hyaluronate.
- The corticosteroid injections also resulted in high levels (up to 20 times the initial level) of proteoglycans. This indicates joint cartilage degradation.
- However, a combined injection of corticosteroids and high molecular weight hyaluronate appeared to reduce proteoglycan breakdown. This suggests a protective effect of hyaluronate on the articular cartilage.
Implications
- The findings could influence the choice of treatment for joint conditions in equines, considering the effects of different compounds in intra-articular injections.
- Understanding the effects of corticosteroids on synoviocyte stimulation and proteoglycan levels might help in modulating treatments to control joint cartilage degradation.
- The protective role of hyaluronate in joint cartilage when combined with corticosteroids offers a potential way to mitigate the degrading effects of corticosteroids.
Cite This Article
APA
Ronéus B, Lindblad A, Lindholm A, Jones B.
(1993).
Effects of intraarticular corticosteroid and sodium hyaluronate injections on synovial fluid production and synovial fluid content of sodium hyaluronate and proteoglycans in normal equine joints.
Zentralbl Veterinarmed A, 40(1), 10-16.
https://doi.org/10.1111/j.1439-0442.1993.tb00595.x Publication
Researcher Affiliations
- Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Faculty of Veterinary Medicine, Uppsala.
MeSH Terms
- Adrenal Cortex Hormones / pharmacology
- Animals
- Female
- Horses / metabolism
- Hyaluronic Acid / analysis
- Hyaluronic Acid / pharmacology
- Male
- Proteoglycans / analysis
- Synovial Fluid / chemistry
- Synovial Fluid / metabolism
Citations
This article has been cited 2 times.- Lindholm A, Ronéus B, Lindblad G, Jones B. Hyaluronan turnover in the synovial fluid in metacarpophalangeal--and middle carpal joints in standardbred horses.. Acta Vet Scand 1996;37(2):147-51.
- Rørvik AM. Methods and errors in measurements of synovial fluid volume in stifles with low volume and high viscosity synovial fluid. An experimental study in goats.. Acta Vet Scand 1995;36(2):213-22.
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