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Journal of veterinary medicine. A, Physiology, pathology, clinical medicine2003; 50(4); 190-195; doi: 10.1046/j.1439-0442.2003.00523.x

Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery.

Abstract: Physiological parameters, metabolic parameters and stress-related hormones are evaluated in horses anaesthetized with isoflurane in oxygen combined with lidocaine intravenously. Two groups of horses anaesthetized with isoflurane (six horses in each group) were studied: a lidocaine group (IL), which received intravenous lidocaine and a control group (C), which received intravenous saline. Horses in both groups were premedicated with detomidine (i.v.), and anaesthesia was induced with midazolam-ketamine (i.v.). The lidocaine group received intravenous lidocaine as a loading dose of 2.5 mg kg(-1) at 15 min after induction of anaesthesia directly followed by a maintenance dosage of 50 microg kg(-1) min(-1), while the control group received saline (i.v.) following the same regime. End-tidal isoflurane and standard physiological parameters were measured. Blood was sampled for measurement of lidocaine, stress hormones and metabolic parameters. The end-tidal isoflurane concentration in the lidocaine group was 0.96 +/- 0.06% versus 1.28 +/- 0.06% (mean +/- SD) in the control group, a significant (P < 0.05) reduction of 25%. No significant differences were found regarding stress-related hormones, metabolic and physiological parameters. This study suggests that the use of lidocaine to decrease the concentration of isoflurane to obtain a sufficient surgical anaesthesia has no subsequent effects on physiological and metabolic parameters or stress-related hormones.
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Publication Date: 2003-09-02 PubMed ID: 12948155DOI: 10.1046/j.1439-0442.2003.00523.xGoogle Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research has analysed how intravenous lidocaine affects physiological and metabolic parameters and stress-related hormones in horses going through surgery, under anaesthesia induced with isoflurane and oxygen. The study showed a significant reduction in isoflurane concentration without significant changes in the other parameters when lidocaine was used.

Study design

  • Two groups of horses, anaesthetized with isoflurane, were studied. Each group contained six horses. The first group, referred to as the lidocaine or “IL” group, received intravenous lidocaine. The other, the control or ‘C’ group, received intravenous saline.
  • All horses were premedicated with detomidine via intravenous route and anaesthesia was introduced using midazolam-ketamine, also intravenously.
  • The lidocaine group was given intravenous lidocaine as a loading dose of 2.5 mg per kg, 15 minutes after anesthesia induction. This was followed by a maintenance dosage of 50 micrograms per kg per minute. The control group received saline in a similar schedule.

Measurements and Results

  • The team measured end-tidal isoflurane concentration, standard physiological parameters, and took blood samples to measure lidocaine, stress hormones and metabolic parameters.
  • The results showcased that the end-tidal isoflurane concentration in the lidocaine group was significantly lower, by 25%, compared to the control group. It was 0.96% versus 1.28% respectively.
  • Interestingly, there were no significant differences found when comparing stress-related hormones, metabolic, and physiological parameters.

Conclusion

  • The study concludes that the use of lidocaine can reduce the concentration of isoflurane necessary to achieve adequate surgical anesthesia. This reduction does not seem to have an impact on metabolic or physiological parameters nor does it significantly change stress-related hormone levels.

Cite This Article

APA
Dzikiti TB, Hellebrekers LJ, van Dijk P. (2003). Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery. J Vet Med A Physiol Pathol Clin Med, 50(4), 190-195. https://doi.org/10.1046/j.1439-0442.2003.00523.x

Publication

Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
ISSN: 0931-184X
NlmUniqueID: 100955112
Country: Germany
Language: English
Volume: 50
Issue: 4
Pages: 190-195

Researcher Affiliations

Dzikiti, T B
  • Section of Veterinary Anaesthesiology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Hellebrekers, L J
    van Dijk, P

      MeSH Terms

      • Anesthesia / veterinary
      • Anesthetics / pharmacology
      • Anesthetics, Combined
      • Anesthetics, Inhalation / pharmacology
      • Anesthetics, Intravenous / pharmacology
      • Anesthetics, Local / pharmacology
      • Animals
      • Drug Interactions
      • Enzymes / blood
      • Female
      • Hemodynamics / drug effects
      • Horses
      • Hydrocortisone / blood
      • Infusions, Intravenous
      • Insulin / blood
      • Isoflurane / pharmacokinetics
      • Ketamine
      • Lidocaine / administration & dosage
      • Male
      • Midazolam
      • Muscle, Skeletal / drug effects
      • Muscle, Skeletal / enzymology
      • Muscle, Skeletal / pathology
      • Stress, Physiological / blood
      • Surgery, Veterinary / methods

      Citations

      This article has been cited 17 times.
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