Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.
Abstract: To compare the effects of 2 NSAIDs (phenylbutazone and meloxicam) on renal function in horses. Methods: 9 Thoroughbred or Standardbred mares (mean ± SD age, 5.22 ± 1.09 years [range, 2 to 12 years]; mean body weight, 470 ± 25 kg [range, 442 to 510 kg]). Methods: A randomized blinded placebo-controlled crossover study was conducted to examine the effects of treatment with phenylbutazone, meloxicam, or a placebo (control solution) on renal responses to the administration of furosemide, dobutamine, and exercise (15 minutes at 60% of maximum heart rate). Renal function was assessed by use of bilateral ureteral catheterization for simultaneous determination of creatinine clearance, sodium excretion, and urine flow rate. Results: Both phenylbutazone and meloxicam attenuated diuresis and natriuresis and reduced glomerular filtration rate, compared with results for the control solution, when horses were treated with furosemide. Mean arterial blood pressure, urine flow rate, and glomerular filtration rate were increased during or after (or both) dobutamine infusion. Both NSAIDs reduced urine flow rate and sodium excretion associated with dobutamine infusion and exercise but had no effect on glomerular filtration rate. Conclusions: Responses to meloxicam, a cyclooxygenase (COX)-2 preferential agent, appeared comparable to those detected after phenylbutazone treatment, which suggested that COX-2 was the mediator of prostanoid-induced changes to renal function in horses and indicated that COX-2-preferential agents would be likely to have adverse renal effects similar to those for nonselective COX inhibitors in volume-depleted horses.
Publication Date: 2014-06-25 PubMed ID: 24959734DOI: 10.2460/ajvr.75.7.668Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Randomized Controlled Trial
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigates how two non-steroidal anti-inflammatory drugs (NSAIDs), namely meloxicam and phenylbutazone, affect kidney function in horses, particularly in response to the drugs furosemide, dobutamine, and exercise.
Methodology
- The research employs a randomized blinded placebo-controlled crossover study involving nine Thoroughbred or Standardbred mares aged between 2 to 12 years.
- Each horse was subjected to three treatments – phenylbutazone, meloxicam, or a placebo – to evaluate their renal responses to applications of furosemide, dobutamine, and exercise for 15 minutes at 60% of their maximum heart rate.
- The renal function was assessed by bilaterally catheterizing the ureters for simultaneous determination of creatinine clearance, sodium excretion, and urine flow rate.
Results
- Both phenylbutazone and meloxicam were found to reduce the effects of diuresis (increased or excessive production of urine) and natriuresis (excretion of sodium in the urine) prompted by furosemide. This also led to a reduction in the glomerular filtration rate, which is a test to measure the level of kidney function and determine the stage of kidney disease.
- After administering dobutamine or conducting exercise, the mean arterial blood pressure, urine flow rate, and glomerular filtration rate were increased.
- Both NSAIDs resulted in reduced urine flow rate and sodium excretion associated with dobutamine infusion and exercise, but these did not impact the glomerular filtration rate.
Conclusion
- The responses to meloxicam, a drug that prefers cyclooxygenase (COX)-2, seemed similar to those from phenylbutazone treatment. This suggests that COX-2 was responsible for causing prostanoid-induced changes to renal function in horses. It further implies that COX-2-preferential agents could potentially have adverse renal effects similar to nonselective COX inhibitors, particularly in horses suffering from volume depletion.
Cite This Article
APA
Raidal SL, Hughes KJ, Charman AL, Nielsen SG, Phillips JK, Noble GK.
(2014).
Effects of meloxicam and phenylbutazone on renal responses to furosemide, dobutamine, and exercise in horses.
Am J Vet Res, 75(7), 668-679.
https://doi.org/10.2460/ajvr.75.7.668 Publication
Researcher Affiliations
- Schools of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia.
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal / pharmacology
- Cardiotonic Agents / administration & dosage
- Cardiotonic Agents / pharmacology
- Cross-Over Studies
- Cyclooxygenase 2 / metabolism
- Diuretics / pharmacology
- Dobutamine / administration & dosage
- Dobutamine / pharmacology
- Female
- Furosemide / administration & dosage
- Furosemide / pharmacology
- Glomerular Filtration Rate / drug effects
- Horses / physiology
- Kidney / drug effects
- Kidney / physiology
- Male
- Meloxicam
- Phenylbutazone / administration & dosage
- Phenylbutazone / pharmacology
- Physical Conditioning, Animal / physiology
- Sodium / pharmacology
- Thiazines / administration & dosage
- Thiazines / pharmacology
- Thiazoles / administration & dosage
- Thiazoles / pharmacology
Citations
This article has been cited 7 times.- Kemp KL, Yuen NKY, Skinner JE, Bertin FR. Effect of Phenylbutazone Administration on Insulin Sensitivity in Horses With Insulin Dysregulation. J Vet Intern Med 2025 Mar-Apr;39(2):e70028.
- Sheverini A, Khezrian A, Shojaeian A. The effects of ketoprofen and meloxicam on oxidative stress through the glutathione pathway after ketamine-xylazine anesthesia and ulcer induction in rats: A comparative study. Vet Anim Sci 2024 Sep;25:100377.
- van Galen G, Divers TJ, Savage V, Schott HC 2nd, Siwinska N. ECEIM consensus statement on equine kidney disease. J Vet Intern Med 2024 Jul-Aug;38(4):2008-2025.
- White JM, Colbath AC, Schott HC 2nd. Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses. J Vet Intern Med 2023 Nov-Dec;37(6):2544-2551.
- Banihashemi SH, Samimi AS, Samimi K, Tajik J. Effects of double intravenous furosemide administration at different doses on clinical variables, electrocardiographic indices and serum electrolytes in miniature donkeys. Vet Res Forum 2023;14(1):53-57.
- Lemonnier LC, Thorin C, Meurice A, Dubus A, Touzot-Jourde G, Couroucé A, Leroux AA. Comparison of Flunixin Meglumine, Meloxicam and Ketoprofen on Mild Visceral Post-Operative Pain in Horses. Animals (Basel) 2022 Feb 21;12(4).
- Samimi AS, Sanjarinejad A. Effects of two-dose intravenous administration of furosemide on clinical variables, electrocardiographic indices and serum electrolytes in dromedary calves. Vet Med Sci 2021 Jul;7(4):1185-1190.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
