Effects of oral administration of equine placental extract supplement on the facial skin of healthy adult women: A randomized, double-blind, placebo-controlled study.
Abstract: Placenta extract is used as an ingredient in ointments for treating dermatological diseases, skin dryness, and for skin beautification. However, the clinical effects of the equine placenta on humans and the underlying mechanism of action are unclear. This randomized, controlled, double-blind study aimed to clinically evaluate the effect of oral intake of equine placental extract on human skin quality. Methods: Healthy women volunteers between the ages of 30 and 59 years (n = 29) were randomly assigned to receive 220 mg of equine placental extract-placebo orally, once daily for 4 weeks. Skin quality parameters such as skin hydration, skin barrier function (transepidermal water loss [TEWL]), and melanin index were assessed at baseline and after 4 weeks of administration. Results: The melanin index was significantly increased in the placebo group, whereas it remained unchanged in the equine placenta group. The pattern of melanin index change was significantly different due to intake or no intake of equine placenta supplements over 4 weeks. No significant difference was found in skin hydration and TEWL between the two groups at 4 weeks of postadministration. It was shown that the intake of the equine placenta was more effective in protecting the skin condition against the change of ultraviolet (UV) sensitively than the change in temperature and humidity. Conclusions: Effect of equine placental extract intake was evident on the cheek skin of the equine placenta group where participants were protected from UV-induced pigmentation. Equine placental extract is useful for decreasing melanin synthesis and melanin content in the human skin and can be used as an effective food supplement to maintain human skin quality.
© 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.
Publication Date: 2022-02-18 PubMed ID: 35224222PubMed Central: PMC8855633DOI: 10.1002/hsr2.522Google Scholar: Lookup
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- Journal Article
Summary
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The research examines the impact of oral consumption of horse placental extract on various qualities of human skin. It specifically finds that it helps to reduce pigmentation, indicating potential use as a dietary supplement for skin health.
Introduction
- Equine placenta or the placenta from horses is commonly used in various beauty products, especially those intended to alleviate skin issues or improve skin quality.
- Despite its widespread application, scientific evidence related to its effectiveness and mechanism remains limited.
- This study aims to fill this knowledge gap by administering equine placental extract orally in a controlled manner to a group of healthy adult women and observing its impact on their skin quality.
Methodology
- The researchers conducted a randomized, double-blind, placebo-controlled study, the gold standard in scientific research design, to ensure the validity and reliability of their findings.
- They selected 29 healthy women aged between 30 and 59 years and gave them either 220mg of equine placental extract or a placebo once a day for four weeks.
- They assessed skin quality parameters such as skin hydration, skin barrier function (measured through transepidermal water loss or TEWL), and melanin index at the start of the study and after four weeks.
Results
- The melanin index, which is a measure of skin pigmentation, significantly increased in the placebo group but remained unchanged in the equine placenta group.
- While there was no significant difference in terms of hydration and TEWL between the two groups, the pattern of change in the melanin index was significantly different depending on equine placenta intake.
- The study indicated that equine placenta intake provided better skin protection against ultraviolet (UV) sensitivity changes compared to temperature and humidity alterations.
Conclusion
- The effects of equine placental extract intake were seen primarily in the skin of the cheeks where the participants were protected from UV-induced pigmentation.
- By reducing melanin synthesis and melanin content in skin, equine placental extract proved beneficial for skin quality maintenance, suggesting its potential use as a dietary supplement for skin health.
Cite This Article
APA
Nagae M, Nishio T, Ohnuki K, Shimizu K.
(2022).
Effects of oral administration of equine placental extract supplement on the facial skin of healthy adult women: A randomized, double-blind, placebo-controlled study.
Health Sci Rep, 5(2), e522.
https://doi.org/10.1002/hsr2.522 Publication
Researcher Affiliations
- Department of Agro-Environmental Sciences, Laboratory of Systematic Forest and Forest Products Sciences, Faculty of Agriculture Graduate School of Kyushu University Fukuoka Japan.
- Dr. Prolabo Japan Co., Ltd Tokyo Japan.
- Department of Biological and Environmental Chemistry Kinki University Kyushu Izuka Japan.
- Department of Agro-Environmental Sciences, Laboratory of Systematic Forest and Forest Products Sciences, Faculty of Agriculture Graduate School of Kyushu University Fukuoka Japan.
Conflict of Interest Statement
Y.N. is the CEO of Dr. PROLABO JAPAN Co., Ltd, Inc. Except for supplement contribution; the funding sources had no role in the design, conduct, or analysis of the study or the decision to submit the manuscript for publication. All the other authors declare no competing interest.
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Citations
This article has been cited 1 times.- Shen LH, Fan L, Zhang Y, Zhu YK, Zong XL, Peng GN, Cao SZ. Protective Effect and Mechanism of Placenta Extract on Liver.. Nutrients 2022 Nov 29;14(23).
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