Effects of pentoxifylline on equine neutrophil function and flow properties.
Abstract: Pentoxifylline has been reported to improve peripheral vascular circulation by altering the flow properties of blood. To determine if the hemorrheological effects of pentoxifylline were mediated by alterations in neutrophil function and/or flow properties, we evaluated the drug's effects on equine neutrophils in vitro. Pentoxifylline, at a concentration of 1 x 10(-1) M, but not at concentrations of 1 x 10(-6) M to 1 x 10(-2) M, markedly suppressed neutrophil superoxide production, zymosan phagocytosis and adherence to nylon wool. Pentoxifylline failed to improve neutrophil filterability through 3 mu polycarbonate filters at any concentration tested. We conclude that equine neutrophil function and flow properties are unlikely to be affected by pentoxifylline concentrations achievable in vivo.
Publication Date: 1992-10-01 PubMed ID: 1335832PubMed Central: PMC1263562
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- Journal Article
Summary
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The research study is about the effects of a drug called pentoxifylline on the function and flow properties of equine neutrophils. The study found that the drug likely doesn’t affect equine neutrophil function and flow properties at concentrations achievable in a live environment.
Understanding Pentoxifylline and its Effect on Neutrophils
The focus is on understanding the effects of pentoxifylline, a drug reported to improve peripheral vascular circulation. The study investigated its impact on equine neutrophils, a type of white blood cell key to fighting infection.
- The study evaluated pentoxifylline’s effects on neutrophils’ ability to suppress superoxide production, its ingestion of foreign particles or organisms (zymosan phagocytosis), and its adherence to nylon wool.
- Superoxide production is an immune response that causes neutrophils to generate reactive oxygen species to kill invading pathogens.
- Zymosan phagocytosis refers to the capacity of neutrophils to ingest zymosan, a type of yeast.
- Adherence to nylon wool measures the neutrophils’ ability to stick to and move along surfaces.
Concentration of Pentoxifylline
The study analysed the impact of pentoxifylline at various concentrations to determine the optimal level at which it affects neutrophil function.
- The study noted a significant effect when pentoxifylline was applied at a concentration of 1 x 10(-1) M, where it noticeably suppressed neutrophil superoxide production, zymosan phagocytosis, and adherence to nylon wool.
- However, at concentrations ranging from 1 x 10(-6) M to 1 x 10(-2) M, pentoxifylline didn’t exhibit any notable influence.
Neutrophil Filterability
Another key parameter analysed in this study was neutrophil filterability, which essentially measures the ease with which neutrophils can pass through a filter.
- The research results indicated that pentoxifylline did not enhance neutrophil filterability at any tested concentration.
Conclusion and Implications
The outcome of the study suggests that pentoxifylline concentrations likely to be achieved in real-life environments are not expected to impact equine neutrophil function and flow properties.
- This result could have important implications for the usage of the drug in veterinary medicine and specifically in the management of equine health.
Cite This Article
APA
Weiss DJ, Geor RJ, Burris SM, Smith CM.
(1992).
Effects of pentoxifylline on equine neutrophil function and flow properties.
Can J Vet Res, 56(4), 313-317.
Publication
Researcher Affiliations
- Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108.
MeSH Terms
- Animals
- Cell Adhesion / drug effects
- Cells, Cultured
- Filtration
- Horses / blood
- Neutrophils / drug effects
- Neutrophils / physiology
- Pentoxifylline / pharmacology
- Phagocytosis / drug effects
- Superoxides / metabolism
References
This article includes 16 references
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Citations
This article has been cited 1 times.- Weiss DJ, Evanson OA, Geor RJ. The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies. Vet Res Commun 1994;18(5):373-81.
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