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Effects of pentoxifylline on equine neutrophil function and flow properties.
Abstract: Pentoxifylline has been reported to improve peripheral vascular circulation by altering the flow properties of blood. To determine if the hemorrheological effects of pentoxifylline were mediated by alterations in neutrophil function and/or flow properties, we evaluated the drug's effects on equine neutrophils in vitro. Pentoxifylline, at a concentration of 1 x 10(-1) M, but not at concentrations of 1 x 10(-6) M to 1 x 10(-2) M, markedly suppressed neutrophil superoxide production, zymosan phagocytosis and adherence to nylon wool. Pentoxifylline failed to improve neutrophil filterability through 3 mu polycarbonate filters at any concentration tested. We conclude that equine neutrophil function and flow properties are unlikely to be affected by pentoxifylline concentrations achievable in vivo.
Publication Date: 1992-10-01 PubMed ID: 1335832PubMed Central: PMC1263562 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research study is about the effects of a drug called pentoxifylline on the function and flow properties of equine neutrophils. The study found that the drug likely doesn’t affect equine neutrophil function and flow properties at concentrations achievable in a live environment.
Understanding Pentoxifylline and its Effect on Neutrophils
The focus is on understanding the effects of pentoxifylline, a drug reported to improve peripheral vascular circulation. The study investigated its impact on equine neutrophils, a type of white blood cell key to fighting infection.
- The study evaluated pentoxifylline’s effects on neutrophils’ ability to suppress superoxide production, its ingestion of foreign particles or organisms (zymosan phagocytosis), and its adherence to nylon wool.
- Superoxide production is an immune response that causes neutrophils to generate reactive oxygen species to kill invading pathogens.
- Zymosan phagocytosis refers to the capacity of neutrophils to ingest zymosan, a type of yeast.
- Adherence to nylon wool measures the neutrophils’ ability to stick to and move along surfaces.
Concentration of Pentoxifylline
The study analysed the impact of pentoxifylline at various concentrations to determine the optimal level at which it affects neutrophil function.
- The study noted a significant effect when pentoxifylline was applied at a concentration of 1 x 10(-1) M, where it noticeably suppressed neutrophil superoxide production, zymosan phagocytosis, and adherence to nylon wool.
- However, at concentrations ranging from 1 x 10(-6) M to 1 x 10(-2) M, pentoxifylline didn’t exhibit any notable influence.
Neutrophil Filterability
Another key parameter analysed in this study was neutrophil filterability, which essentially measures the ease with which neutrophils can pass through a filter.
- The research results indicated that pentoxifylline did not enhance neutrophil filterability at any tested concentration.
Conclusion and Implications
The outcome of the study suggests that pentoxifylline concentrations likely to be achieved in real-life environments are not expected to impact equine neutrophil function and flow properties.
- This result could have important implications for the usage of the drug in veterinary medicine and specifically in the management of equine health.
Cite This Article
APA
Weiss DJ, Geor RJ, Burris SM, Smith CM.
(1992).
Effects of pentoxifylline on equine neutrophil function and flow properties.
Can J Vet Res, 56(4), 313-317.
Publication
Researcher Affiliations
- Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108.
MeSH Terms
- Animals
- Cell Adhesion / drug effects
- Cells, Cultured
- Filtration
- Horses / blood
- Neutrophils / drug effects
- Neutrophils / physiology
- Pentoxifylline / pharmacology
- Phagocytosis / drug effects
- Superoxides / metabolism
References
This article includes 16 references
- Puranapanda V, Hinshaw LB, O'Rear EA, Chang AC, Whitsett TL. Erythrocyte deformability in canine septic shock and the efficacy of pentoxifylline and a leukotriene antagonist.. Proc Soc Exp Biol Med 1987 Jun;185(2):206-10.
- Kwong EC, Chen FC, Young LM. Urinary excretion of pentoxifylline and its metabolites by standardbred mares.. Can J Vet Res 1989 Apr;53(2):147-53.
- Ambrus JL, Anain JM, Anain SM, Anain PM, Anain JM Jr, Stadler S, Mitchell P, Brobst JA, Cobert BL, Savitsky JP. Dose-response effects of pentoxifylline on erythrocyte filterability: clinical and animal model studies.. Clin Pharmacol Ther 1990 Jul;48(1):50-6.
- Ehrly AM. Drugs that alter blood viscosity. Their role in therapy.. Drugs 1990 Feb;39(2):155-9.
- Colles CM. A preliminary report on the use of warfarin in the treatment of navicular disease.. Equine Vet J 1979 Jul;11(3):187-90.
- Ishizaka A, Wu ZH, Stephens KE, Harada H, Hogue RS, O'Hanley PT, Raffin TA. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline.. Am Rev Respir Dis 1988 Aug;138(2):376-82.
- Braide M, Sonander H, Johansson BR, Bagge U. Leukocyte effects on microcirculation in artificially perfused rat lungs.. Am J Physiol 1989 Apr;256(4 Pt 2):H1117-26.
- Fazely F, Dezube BJ, Allen-Ryan J, Pardee AB, Ruprecht RM. Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells.. Blood 1991 Apr 15;77(8):1653-6.
- Weiss DJ, Kraemer R, Schmit K. Isolation of granulocytes and mononuclear cells from the blood of dogs, cats, horses and cattle.. Vet Clin Pathol 1989;18(2):33-6.
- Beermann B, Ings R, Månsby J, Chamberlain J, McDonald A. Kinetics of intravenous and oral pentoxifylline in healthy subjects.. Clin Pharmacol Ther 1985 Jan;37(1):25-8.
- Krause PJ, Maderazo EG, Contrino J, Eisenfeld L, Herson VC, Greca N, Bannon P, Kreutzer DL. Modulation of neonatal neutrophil function by pentoxifylline.. Pediatr Res 1991 Feb;29(2):123-7.
- Ciuffetti G, Mercuri M, Rizzo MT, Lombardini R, Mannarino E. Human leucocyte rheology and tissue ischaemia.. Eur J Clin Invest 1989 Jun;19(3):323-7.
- Josaki K, Contrino J, Kristie J, Krause P, Kreutzer DL. Pentoxifylline-induced modulation of human leukocyte function in vitro.. Am J Pathol 1990 Mar;136(3):623-30.
- Hand WL, Butera ML, King-Thompson NL, Hand DL. Pentoxifylline modulation of plasma membrane functions in human polymorphonuclear leukocytes.. Infect Immun 1989 Nov;57(11):3520-6.
- Komatsu H, Koo A, Guth PH. Leukocyte flow dynamics in the rat liver microcirculation.. Microvasc Res 1990 Jul;40(1):1-13.
- Nagahata H, Sako T, Reiter JA, DiBartola SP, Couto CG, Kociba GJ. Neutrophil adherence, phagocytic-nitroblue tetrazolium reduction and chemiluminescence in canine whole blood.. Vet Res Commun 1991;15(3):181-8.
Citations
This article has been cited 1 times.- Weiss DJ, Evanson OA, Geor RJ. The effects of furosemide and pentoxifylline on the flow properties of equine erythrocytes: in vitro studies. Vet Res Commun 1994;18(5):373-81.
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