Effects of prostaglandin F2alpha on the oestrous cycle and pregnancy in mares.
Abstract: Several experiments indicated that prostaglandin F2alpha (PGF2alpha) has luteolytic and abortifacient properties in mares. A single subcutaneous injection of 1-25 mg PGF2alpha on Day 6 of dioestrus was as effective as 10 mg PGF2alpha in inducing luteolysis. Oestrus and ovulation appeared to be synchronized when a single injection of 1-25 mg PGF2alpha was given on Days 7, 10 or 13 after ovulation but not on Days 1 or 4 after ovulation or on Day 2 of oestrus. Intramuscular administration was as effective as subcutaneous administration and 1-25 mg PGF2alpha was the minimal effective systemic dose to induce luteolysis. Administration of PGF2alpha into the uterus or directly into the CL did not improve the luteolytic efficacy of the intramuscular injection of PGF2alpha. All thirteen mares aborted following injections of 2-5 mg PGF2alpha at 12-hr intervals; an average of 3-7 injections were given before abortion occurred.
Publication Date: 1975-10-01 PubMed ID: 1060788
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- Journal Article
- Research Support
- U.S. Gov't
- P.H.S.
Summary
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The researchers aimed to understand the effects of prostaglandin F2alpha (PGF2alpha) on the cycle and pregnancy in mares, and concluded that it has potential to induce luteolysis, synchronize ovulation and cause abortion.
Prostaglandin F2alpha and its Application
- The study revolves around prostaglandin F2alpha (PGF2alpha), a hormone known for its potential to cause luteolysis (degradation of the corpus luteum, which is part of the ovarian cycle) and induce abortion in horses.
- A range of doses were used in the study, with findings indicating that a single subcutaneous injection of 1–25 mg PGF2alpha on Day 6 of the dioestrus stage (period during the estrous cycle when the mare is not in heat) was as effective in inducing luteolysis as a 10 mg dose.
Timing of Injection and Effects on Oestrus and Ovulation
- The timing of the injection played a significant role in the synchronization of oestrus (heat cycle) and ovulation.
- Results suggested that a single injection of 1–25 mg PGF2alpha when given on days 7, 10, or 13 after ovulation was successful in achieving synchronization. Conversely, injections did not have the same effect when administered on days 1 or 4 post-ovulation, or on the second day of oestrus.
Comparison of Intramuscular and Subcutaneous Administration
- A comparison was made between the intramuscular and subcutaneous administration of PGF2alpha, concluding no significant difference in their effectiveness.
- A minimum systemic dose as low as 1–25 mg PGF2alpha was enough to prompt luteolysis, indicating its potency and physiological influence.
Influence of Prostaglandin F2alpha on Pregnancy
- In terms of its impact on pregnancy, researchers found that PGF2alpha had powerful abortifacient properties.
- Administration of doses between 2–5 mg of PGF2alpha at 12-hour intervals led all thirteen pregnant mares in the study to abort. An average of 3–7 injections were needed to induce abortion, detailing its rapid and strong abortifacient effects.
Cite This Article
APA
Douglas RH, Ginther OJ.
(1975).
Effects of prostaglandin F2alpha on the oestrous cycle and pregnancy in mares.
J Reprod Fertil Suppl(23), 257-261.
Publication
Researcher Affiliations
MeSH Terms
- Abortion, Induced / veterinary
- Abortion, Veterinary / chemically induced
- Animals
- Corpus Luteum / drug effects
- Estrus / drug effects
- Female
- Horses / physiology
- Injections, Intramuscular
- Injections, Subcutaneous
- Ovulation / drug effects
- Pregnancy
- Prostaglandins F / administration & dosage
- Prostaglandins F / pharmacology
- Time Factors
Citations
This article has been cited 3 times.- Maranesi M, Petrucci L, Leonardi L, Bufalari A, Parillo F, Boiti C, Zerani M. Kisspeptin/kisspeptin receptor system in pseudopregnant rabbit corpora lutea: presence and function. Sci Rep 2019 Mar 25;9(1):5044.
- Parillo F, Maranesi M, Mignini F, Marinelli L, Di Stefano A, Boiti C, Zerani M. Evidence for a dopamine intrinsic direct role in the regulation of the ovary reproductive function: in vitro study on rabbit corpora lutea. PLoS One 2014;9(8):e104797.
- Mitchell D, de Gannes R, Sugden EA. Prostaglandin F2alpha treatment of cyclic dysfunction in mares. Can Vet J 1976 Dec;17(12):301-7.
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