Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses.
Abstract: To quantitate effects of dose of sevoflurane and mode of ventilation on cardiovascular and respiratory function in horses and identify changes in serum biochemical values associated with sevoflurane anesthesia. Methods: 6 healthy adult horses. Methods: Horses were anesthetized twice: first, to determine the minimum alveolar concentration (MAC) of sevoflurane and second, to characterize cardiopulmonary and serum biochemical responses of horses to 1.0, 1.5, and 1.75 MAC multiples of sevoflurane during controlled and spontaneous ventilation. Results-Mean (+/- SEM) MAC of sevoflurane was 2.84 +/- 0.16%. Cardiovascular performance during anesthesia decreased as sevoflurane increased; the magnitude of cardiovascular depression was more severe during mechanical ventilation, compared with spontaneous ventilation. Serum inorganic fluoride concentration increased to a peak of 50.8 +/- 7.1 micromol/L at the end of anesthesia. Serum creatinine concentration and sorbitol dehydrogenase activity reached their greatest values (2.0 +/- 0.8 mg/dL and 10.2 +/- 1.8 U/L, respectively) at 1 hour after anesthesia and then returned to baseline by 1 day after anesthesia. Serum creatine kinase, aspartate aminotransferase, and alkaline phosphatase activities reached peak values by the first (ie, creatine kinase) or second (ie, aspartate aminotransferase and alkaline phosphatase) day after anesthesia. Conclusions: Sevoflurane causes dose-related cardiopulmonary depression, and mode of ventilation further impacts the magnitude of this depression. Except for serum inorganic fluoride concentration, quantitative alterations in serum biochemical indices of liver- and muscle-cell disruption and kidney function were considered clinically unremarkable and similar to results from comparable studies of other inhalation anesthetics.
Publication Date: 2005-05-20 PubMed ID: 15900940DOI: 10.2460/ajvr.2005.66.606Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research investigates how varying doses of the anesthetic sevoflurane and different modes of ventilation impact the cardiovascular, respiratory and blood biochemical functions in horses.
Research Method and Process
- The study was conducted on six healthy adult horses.
- Each horse was anesthetized twice. The first time was to determine their minimum alveolar concentration (MAC) of sevoflurane.
- The second stage of research involved the characterization of the horse’s cardiopulmonary and serum biochemical responses when given 1.0, 1.5, and 1.75 MAC multiples of sevoflurane, during both controlled (mechanical) and spontaneous ventilation.
Major Findings
- The average MAC of sevoflurane for the test horses was found to be 2.84 +/- 0.16%.
- As the administered dose of sevoflurane increased, it resulted in a decrease in cardiovascular performance during anesthesia. The severity of cardiovascular depression was more pronounced during mechanical ventilation as compared to spontaneous ventilation.
- The level of serum inorganic fluoride in the blood increased, reaching a peak of 50.8 +/- 7.1 micromol/L by the end of anesthesia.
- Two indicators of kidney function, serum creatinine concentration, and sorbitol dehydrogenase activity, demonstrated their highest respective values (2.0 +/- 0.8 mg/dL and 10.2 +/- 1.8 U/L) an hour post-anesthesia, thereafter returning to baseline the following day.
- Both aspartate aminotransferase and alkaline phosphatase (markers for liver and muscle cell activity) along with creatine kinase (a marker of muscle damage), reached their peak levels the first or second day after anesthesia respectively.
Conclusions and Implications
- Administering sevoflurane causes a dose-dependant decrease in cardiopulmonary function and this depression is further influenced by the mode of ventilation used.
- Aside from the measured increase in serum inorganic fluoride concentration, alterations in other serum biochemical indices, which are indicative of liver, muscle damage and kidney function, were not deemed clinically significant, and were seen to be comparable to results from similar studies using other inhalation anesthetics.
Cite This Article
APA
Steffey EP, Mama KR, Galey FD, Puschner B, Woliner MJ.
(2005).
Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses.
Am J Vet Res, 66(4), 606-614.
https://doi.org/10.2460/ajvr.2005.66.606 Publication
Researcher Affiliations
- Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
MeSH Terms
- Anesthesia Recovery Period
- Anesthetics, Inhalation / pharmacology
- Animals
- Blood Chemical Analysis / veterinary
- Blood Gas Analysis / veterinary
- Blood Pressure / drug effects
- Dose-Response Relationship, Drug
- Female
- Heart Rate / drug effects
- Horses / blood
- Horses / physiology
- Male
- Methyl Ethers / pharmacology
- Random Allocation
- Respiration, Artificial / veterinary
- Respiratory Function Tests / veterinary
- Sevoflurane
Citations
This article has been cited 8 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
- Tokushige H, Araki M, Kusano K, Arima D, Ito H, Yamazaki Y, Urayama S, Kambayashi Y, Tateno O, Ohta M. A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.. J Equine Sci 2019 Jul;30(2):25-31.
- Wei H, Li W, Jiang Z, Xi X, Qi G. Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum.. Exp Ther Med 2019 Jul;18(1):411-417.
- Tokushige H, Kushiro A, Okano A, Maeda T, Ito H, Wakuno A, Nagata SI, Ohta M. Clinical evaluation of constant rate infusion of alfaxalone-medetomidine combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery.. Acta Vet Scand 2018 Sep 4;60(1):50.
- Conde Ruiz C, Junot S. Successful Cardiopulmonary Resuscitation in a Sevoflurane Anaesthetized Horse That Suffered Cardiac Arrest at Recovery.. Front Vet Sci 2018;5:138.
- Mizobe F, Wakuno A, Okada J, Otsuka T, Ishikawa Y, Kurimoto S. Clinical usefulness of intravenous constant rate infusion of fentanyl and medetomidine under sevoflurane anesthesia in Thoroughbred racehorses undergoing internal fixation surgery.. J Equine Sci 2017;28(4):143-147.
- Brosnan RJ. Inhaled anesthetics in horses.. Vet Clin North Am Equine Pract 2013 Apr;29(1):69-87.
- Chesnel MA, Aprea F, Clutton RE. Anesthetic management of a horse with traumatic pneumothorax.. Can Vet J 2012 Jun;53(6):648-52.
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