Effects of topical application of pirfenidone ointment on thermoplasty-induced acute lameness in a double-blind and acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial in horses.
Abstract: The effectiveness of pirfenidone ointment against thermoplasty-induced acute foreleg lameness in a double-blind study, and against acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial was evaluated in this study. Thermoplasty was performed on both inner forelegs at designated locations of each horse under anesthetics. A 10% pirfenidone or placebo ointment was topically applied starting 24 hours after the thermoplasty three times daily for 7 days. For acute and chronic lameness of musculoskeletal origin, pirfenidone ointment was also applied one to three times daily for 7 to 10 days and continued for an additional 20 to 30 days. A marked swelling around the locations occurred in 24 hours post-thermoplasty. The topical application of pirfenidone ointment not only caused a significant reduction in the circumference measurements at 5, 6 and 7 days, but it also decreased the changes in the circumferences from pre-thermoplasty as an index of edema, at 3, 4, 5, 6, and 7 days when compared to the placebo ointment at the corresponding times. Although treatment for 7 days of acute leg lameness of musculoskeletal origin with topical pirfenidone ointment caused significant decreases in swelling, heat, and pain, and improved the degree of flexion when compared with the pretreatment, it had little effect on chronic lameness except that it improved the flexion at the second-exam interval. It was concluded that topical application of pirfenidone is effective for treatment of acute lameness resulting from thermoplasty or from various types of musculoskeletal disorders, suggesting that pirfenidone offers a promising therapeutic potential to manage acute inflammation, an important component of lameness.
Publication Date: 2008-04-23 PubMed ID: 18426078
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- Journal Article
- Multicenter Study
- Randomized Controlled Trial
Summary
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The research study explores the effectiveness of using pirfenidone ointment as a treatment for acute lameness in horses caused by thermoplasty or musculoskeletal disorders. Topical application of the ointment significantly reduced swelling and improved flexibility, suggesting pirfenidone could be a promising therapeutic solution to manage acute inflammation associated with these conditions.
Objective of the Study
- The main goal of this research was to determine the effectiveness of pirfenidone ointment when applied topically for treating acute lameness in horses. This condition was either induced through thermoplasty or arose due to acute and chronic musculoskeletal disorders.
Methodology
- Thermoplasty was conducted on the inner forelegs of horses under anesthesia. Post-thermoplasty, a placebo or a 10% pirfenidone ointment was applied topically three times daily for a duration of one week.
- For horses suffering from acute and chronic musculoskeletal lameness, the pirfenidone ointment was applied one to three times a day for a period of 7 to 10 days, with treatment extended for another 20 to 30 days.
Key Findings
- Notable swelling was observed around the thermoplasty site 24 hours after the procedure. Applying pirfenidone ointment topically resulted in a significant reduction in the measurements of swelling on the 5th, 6th and 7th day post-procedure compared to the placebo ointment.
- For cases of acute leg lameness arising from musculoskeletal disorders, treatment with pirfenidone ointment made noticeable improvements in terms of reducing swelling, relieving pain, and increasing the degree of joint flexibility post-treatment.
- However, the ointment had minimal effects on chronic lameness cases, except for improving the flexibility at the second-exam interval.
Conclusion
- The study concludes that the topical application of pirfenidone is an effective therapeutic intervention for treating acute lameness in horses whether caused by thermoplasty or different types of musculoskeletal disorders.
- This ointment potentially offers a new treatment approach to manage acute inflammation, a significant component of lameness.
Cite This Article
APA
Giri SN, Margolin SB.
(2008).
Effects of topical application of pirfenidone ointment on thermoplasty-induced acute lameness in a double-blind and acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial in horses.
Res Commun Mol Pathol Pharmacol, 117-118, 47-63.
Publication
Researcher Affiliations
- Marnac, Inc., 9400 N. Central Expressway, Suite 305 Dallas, Texas 75231, USA. solananinc@aol.com
MeSH Terms
- Administration, Topical
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal / adverse effects
- Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
- Double-Blind Method
- Edema / pathology
- Female
- Forelimb / pathology
- Horse Diseases / drug therapy
- Horse Diseases / pathology
- Horses
- Hot Temperature / adverse effects
- Inflammation / pathology
- Lameness, Animal / drug therapy
- Lameness, Animal / pathology
- Male
- Ointments
- Pyridones / administration & dosage
- Pyridones / adverse effects
- Pyridones / therapeutic use
Citations
This article has been cited 1 times.- Gan Y, Herzog EL, Gomer RH. Pirfenidone treatment of idiopathic pulmonary fibrosis. Ther Clin Risk Manag 2011 Feb 8;7:39-47.
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