Effects of two different dosages of dobutamine on pulmonary artery wedge pressure, systemic arterial blood pressure and heart rate in anaesthetized horses.
Abstract: The purpose of the present study was to investigate the effects of two different dobutamine concentrations on pulmonary artery wedge pressure (PAWP) and on mean systemic arterial blood pressure (MAP) in horses anaesthetized with isoflurane, after induction of general anaesthesia with xylazine, ketamine and diazepam. Eight healthy warm-blood horses were included in the study. Each horse was subjected to general anaesthesia twice with two different dosages of dobutamine, 3 and 5 microg/kg bw/min, being infused over 15 min, starting 50 min after induction of general anaesthesia (T(0)). The heart rate, the PAWP and the MAP were recorded after 10 min (T(1)) and then every 5 min until 15 min after cessation of intravenous dobutamine administration (T(3)-T(5)). The PAWP was measured by a right heart catheter, which was positioned in the pulmonary capillaries. Mean systemic arterial blood pressure was monitored at the facial artery for the duration of general anaesthesia. All parameters increased at both dosage rates of dobutamine and decreased significantly when dobutamine administration ceased. The increase in heart rate was significantly higher after administration of 3 microg/kg bw/min dobutamine compared with the dosage of 5 microg/kg bw/min dobutamine. The increase in MAP was also higher at this dosage, but not significantly different to the dosage of 5 microg/kg bw/min dobutamine. During both dosages the MAP was above a value considered to be compatible with good peripheral circulation. The greater increase in PAWP was observed during administration of 5 g/kg bw/min dobutamine, but PAWP was not significantly different with the dosage of 3 microg/kg bw/min dobutamine. In conclusion, the administration of dobutamine led to an increase in MAP and PAWP above a value considered to be compatible with a good peripheral circulation. The results of the present study indicate that dobutamine improves circulation, in addition to its well-known effect on the periphery.
Publication Date: 2006-10-24 PubMed ID: 17054485DOI: 10.1111/j.1439-0442.2006.00860.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
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The research investigated the impact of two different concentrations of dobutamine on pulmonary artery wedge pressure and mean systemic arterial blood pressure in anaesthetized horses. The results suggest that dobutamine improves circulation beyond its known peripheral effects.
Objective
The main objective was to study the effects of two different dobutamine concentrations on pulmonary artery wedge pressure (PAWP) and mean systemic arterial blood pressure (MAP) in horses anaesthetized with isoflurane.
Method
- The study involved eight healthy warm-blood horses that were subjected to general anesthesia twice with two different dosages of dobutamine administered.
- The dosages of dobutamine used were 3 and 5 microg/kg bw/min, infused over 15 minutes.
- Measurements such as heart rate, PAWP, and MAP were recorded after 10 minutes and then every 5 minutes until 15 minutes after cessation of dobutamine administration.
- The PAWP was measured using a right heart catheter positioned in the pulmonary capillaries.
- Mean systemic arterial blood pressure was monitored at the facial artery for the duration of general anaesthesia.
Results
- All parameters, including heart rate, PAWP, and MAP, increased at both dosage rates of dobutamine and decreased significantly when the administration of dobutamine ceased.
- The administration of 3 microg/kg bw/min dobutamine caused a significantly higher increase in heart rate compared to the dosage of 5 microg/kg bw/min dobutamine.
- The increase in MAP was also higher at this dosage but was not significantly different from the dosage of 5 microg/kg bw/min dobutamine.
- The greatest increase in PAWP was observed during administration of 5 g/kg bw/min dobutamine, though PAWP was not significantly different with the dosage of 3 microg/kg bw/min dobutamine.
Conclusion
The study concluded that the administration of dobutamine led to an increase in MAP and PAWP, denoting good peripheral circulation. Dobutamine was found to enhance circulation beyond its well-documented peripheral effects, which implies it could be used in managing anesthetized horses by enhancing their circulation while they are under general anesthesia.
Cite This Article
APA
Gehlen H, Weichler A, Bubeck K, Ohnesorge B, Deegen E, Stadler P.
(2006).
Effects of two different dosages of dobutamine on pulmonary artery wedge pressure, systemic arterial blood pressure and heart rate in anaesthetized horses.
J Vet Med A Physiol Pathol Clin Med, 53(9), 476-480.
https://doi.org/10.1111/j.1439-0442.2006.00860.x Publication
Researcher Affiliations
- Klinik für Pferde, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D-30173 HannoverKlinik für Pferde, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany. heidrun.gehlen@tiho-hannover.de
MeSH Terms
- Adrenergic beta-Agonists / pharmacology
- Anesthesia / veterinary
- Animals
- Blood Pressure / drug effects
- Blood Pressure / physiology
- Cross-Over Studies
- Dobutamine / pharmacology
- Dose-Response Relationship, Drug
- Female
- Heart Rate / drug effects
- Heart Rate / physiology
- Horses / physiology
- Male
- Pulmonary Wedge Pressure / drug effects
- Pulmonary Wedge Pressure / physiology
Citations
This article has been cited 2 times.- Alimi H, Mirzaei A, Farzaghi MS, Rahimi VB. Hypertensive Response During Dobutamine Stress Echocardiography: Does it Indicate a Higher Risk of Developing Hypertension?. J Cardiovasc Echogr 2025 Jul-Sep;35(3):264-270.
- Gorenberg EB, Slack J, Stefanovski D, Theiss D, Hopster K. Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane-anaesthetised horses. Equine Vet J 2025 Nov;57(6):1677-1689.
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