Effects of Various Methods of Sulpiride Administration on Prolactin Release in Horses.
Abstract: Four experiments assessed factors affecting prolactin responses to sulpiride administration in horses. Experiment 1 compared the efficacy of the (-) enantiomer of sulpiride to that of the commonly used (+/-) racemic mixture. Mares were used in an 8 × 8 Latin square to compare the prolactin responses to four doses of levosulpiride to four corresponding doses of the racemic mixture at twice the dose. Responses at each dose indicated equal and similar (P > .1) responses. Experiment 2 compared the efficacy of 1 gram of orally administered racemic sulpiride to 100 mg of intramuscularly injected sulpiride in oil in mares primed with 50 mg of estradiol cypionate (ECP). Prolactin responses in groups receiving sulpiride were robust but similar in magnitude with minor differences in timing. In experiment 3, ECP-primed geldings received subcutaneous injections of 1.8 grams racemic sulpiride in vegetable shortening in one of three sites: the neck, the back below the withers, or the lower girth region; control geldings received no sulpiride. Prolactin responses to sulpiride lasted a minimum of 96 hours. In experiment 4, prolactin responses to 3 g of racemic sulpiride in vegetable shortening were compared to similar injections (3 g) in 5 mL of sucrose acetate isobutyrate (SAIB; SucroMate) or just SAIB (control) in ECP-primed geldings. Controls had no prolactin response to SucroMate, whereas both treatment groups had extended prolactin responses lasting at least 10 days. It is concluded that prolactin responses to sulpiride in horses can be greatly extended by using hydrophobic vehicles like vegetable shortening or SAIB.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication Date: 2018-05-26 PubMed ID: 31256886DOI: 10.1016/j.jevs.2018.05.211Google Scholar: Lookup
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This research explores the effects of various methods of sulpiride administration on the release of prolactin in horses, showing that the duration of prolactin responses can be significantly extended by using hydrophobic vehicles like vegetable shortening or SucroMate.
Experiment 1: Comparison of Different Sulpiride Enantiomers
- The first experiment assessed the efficacy of the (-) enantiomer of sulpiride compared to the commonly used (+/-) racemic mixture.
- Mares were used in this study and compared for prolactin responses to four doses of levosulpiride and four corresponding doses of the racemic mixture at twice the dose.
- The results indicated that the responses at each dose were equal and similar, suggesting that either enantiomer could be used without significant difference in effect.
Experiment 2: Comparison of Oral vs. Injected Sulpiride
- Experiment two compared the efficacy of 1 gram of orally administered racemic sulpiride to 100 mg of intramuscularly injected sulpiride in oil in mares that were primed with 50 mg of estradiol cypionate (ECP).
- The prolactin response in groups receiving sulpiride was robust but similar in magnitude, with minor differences in timing.
- This indicates that the method of administration (oral vs. intramuscular) had little effect on the overall prolactin response.
Experiment 3: Effect of Injection Site on Prolactin Response
- Experiment three involved ECP-primed geldings that received subcutaneous injections of 1.8 grams racemic sulpiride in vegetable shortening in one of three sites: the neck, the back below the withers, or the lower girth region.
- Control geldings received no sulpiride.
- Prolactin responses to sulpiride lasted a minimum of 96 hours in all cases, indicating that the site of subcutaneous injection does not notably affect the duration of the prolactin response.
Experiment 4: Hydrophobic Vehicles and Prolactin Response
- The final experiment compared the prolactin responses to 3 grams of racemic sulpiride in vegetable shortening with similar injections in 5 mL of sucrose acetate isobutyrate (SAIB; SucroMate), or SAIB alone, in ECP-primed geldings.
- Controls had no prolactin response to SucroMate, whereas both treatment groups had extended prolactin responses lasting at least 10 days.
- The conclusion from this experiment is that the duration of prolactin responses to sulpiride in horses can be significantly extended by using hydrophobic vehicles like vegetable shortening or SAIB.
Cite This Article
APA
Arana Valencia N, Thompson DL, Southerland CV.
(2018).
Effects of Various Methods of Sulpiride Administration on Prolactin Release in Horses.
J Equine Vet Sci, 68, 39-45.
https://doi.org/10.1016/j.jevs.2018.05.211 Publication
Researcher Affiliations
- School of Animal Sciences, Louisiana Agricultural Experiment Station, LSU AgCenter, Baton Rouge, LA, USA.
- School of Animal Sciences, Louisiana Agricultural Experiment Station, LSU AgCenter, Baton Rouge, LA, USA. Electronic address: dthompson@agctr.lsu.edu.
- School of Animal Sciences, Louisiana Agricultural Experiment Station, LSU AgCenter, Baton Rouge, LA, USA.
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