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Home / Equine Research Bank / J Vet Med Sci / Efficacy and safety of lomefloxacin on bacterial extraocular...
The Journal of veterinary medical science2015; 77(7); 829-835; doi: 10.1292/jvms.14-0507

Efficacy and safety of lomefloxacin on bacterial extraocular disease in the horse.

Abstract: Lomefloxacin is a broad-spectrum fluoroquinolone antibiotic used for the treatment of bacterial extraocular disease. This study investigated the efficacy and safety of lomefloxacin eye drops for bacterial extraocular disease in horses. Lomefloxacin ophthalmic solution (0.3%) was instilled three times daily for 2-5 days in 65 horses diagnosed with bacterial extraocular disease based on clinical findings. Clinical observations and bacteriological examinations were performed at the start of treatment, 2 and 5 days after the start of treatment, and at the discontinuation or termination of treatment. Of the 65 horses, 64 were positive for bacteria, and 22 bacterial genera and 47 bacterial species were identified. The efficacy of lomefloxacin was evaluated in 63 horses; one horse with a negative culture and another with suspected bacterial contamination were excluded. Lomefloxacin was considered to be clinically effective in 54 horses. The major bacterial species identified were Staphylococcus aureus, Streptococcus equi subsp. zooepidemicus, Acinetobacter lwoffii, Staphylococcus xylosus, Staphylococcus vitulinus, Enterobacter agglomerans, Flavimonas oryzihabitans and Staphylococcus sciuri, with a cumulative disappearance rate of 80% or more at the termination of instillation. Excluding one horse that did not undergo a bacteriological examination, the remaining 62 horses were assessed for bacteriological outcome. Full or partial bacterial clearance was detected in 95% or more of the 62 horses. One of the 65 horses reported adverse events that had no causal relation with the eye drops. Our results showed that lomefloxacin is safe and effective for the treatment of bacterial extraocular disease in horses.
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Publication Date: 2015-03-15 PubMed ID: 25787926PubMed Central: PMC4527505DOI: 10.1292/jvms.14-0507Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study examines the effectiveness and safety of an antibiotic known as lomefloxacin for treating bacterial extraocular disease in horses.

Research Purpose and Method

  • The aim of this study was to test the effectiveness and safety of lomefloxacin, a broad-spectrum antibiotic, in treating horses with bacterial extraocular disease. This disease affects the tissues and structures surrounding the eyeball or located on the surface of the eye.
  • The researchers utilized a lomefloxacin ophthalmic solution (0.3%), which was applied directly into the eyes of the study horses three times a day for a period of 2-5 days.
  • The study included 65 horses with clinical signs of bacterial extraocular disease. The health condition of these horses was closely observed and bacteriological examinations were performed at different stages: at the start of treatment, after 2 and 5 days, and at the termination or discontinuation of treatment.

Key Findings

  • Out of the 65 horses, 64 were found to be positive for bacteria. In total, 22 bacterial genera and 47 bacterial species were identified.
  • However, lomefloxacin’s effectiveness was evaluated only in 63 horses; one horse with a negative culture and another with suspected bacterial contamination were excluded.
  • The drug was deemed clinically effective in 54 horses. Due to the treatment with lomefloxacin, a cumulative disappearance rate of 80% or higher was achieved for the majority of identified bacterial species.
  • Full or partial bacterial clearance was spotted in at least 95% of the 62 horses that received the bacteriological examination.
  • Adverse events were reported in only one of the 65 horses, which was not related to the eye drops treatment. This demonstrates a high safety proficient level of lomefloxacin for its use in horses.

Conclusions

  • Based on the study outcomes, the researchers concluded that lomefloxacin is a secure and effective treatment for bacterial extraocular disease in horses.

Cite This Article

APA
Hidaka S, Kobayashi M, Ando K, Fujii Y. (2015). Efficacy and safety of lomefloxacin on bacterial extraocular disease in the horse. J Vet Med Sci, 77(7), 829-835. https://doi.org/10.1292/jvms.14-0507

Publication

The Journal of veterinary medical science
ISSN: 1347-7439
NlmUniqueID: 9105360
Country: Japan
Language: English
Volume: 77
Issue: 7
Pages: 829-835

Researcher Affiliations

Hidaka, Shuhei
  • Horse Clinic, Bloodhorse Training Center (BTC), 141 Nishisha, Urakawa-cho, Urakawa-gun, Hokkaido 057-0171, Japan.
Kobayashi, Mitsutoshi
    Ando, Kunihide
      Fujii, Yoshikazu

        MeSH Terms

        • Administration, Ophthalmic
        • Animals
        • Anti-Bacterial Agents / adverse effects
        • Anti-Bacterial Agents / therapeutic use
        • Eye Infections, Bacterial / drug therapy
        • Eye Infections, Bacterial / microbiology
        • Eye Infections, Bacterial / veterinary
        • Female
        • Fluoroquinolones / adverse effects
        • Fluoroquinolones / therapeutic use
        • Horse Diseases / drug therapy
        • Horse Diseases / microbiology
        • Horses
        • Male
        • Ophthalmic Solutions
        • Treatment Outcome

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        Citations

        This article has been cited 2 times.
        1. Agerholm JS, Klas EM, Damborg P, Borel N, Pedersen HG, Christoffersen M. A Diagnostic Survey of Aborted Equine Fetuses and Stillborn Premature Foals in Denmark. Front Vet Sci 2021;8:740621.
          doi: 10.3389/fvets.2021.740621pubmed: 34859085google scholar: lookup
        2. Zak A, Siwinska N, Slowikowska M, Borowicz H, Ploneczka-Janeczko K, Chorbinski P, Niedzwiedz A. Conjunctival aerobic bacterial flora in healthy Silesian foals and adult horses in Poland. BMC Vet Res 2018 Aug 31;14(1):261.
          doi: 10.1186/s12917-018-1598-6pubmed: 30170594google scholar: lookup
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