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Home / Equine Research Bank / Can Vet J / Efficacy of a paste formulation of omeprazole for the treatm...
The Canadian veterinary journal = La revue veterinaire canadienne2003; 44(7); 581-585;

Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada.

Abstract: The efficacy of a paste formulation of the H+, K+, -ATPase inhibitor omeprazole was evaluated in standardbred racehorses for the treatment and prevention of gastric ulcers. Twenty standardbred racehorses in training, aged 2 to 9 years, were enrolled from 2 training centres in this field trial. Endoscopic examinations confirmed the presence of gastric ulcers in all horses, prior to allocation and treatment and on day 0. Lesions were scored on a scale of 0 to 3 (intact epithelium to extensive ulceration). Replicates were formed, based on training level and location. Within replicates, 1 horse was assigned to group 1 and 3 horses were assigned to group 2, randomly. Horses in group 1 were sham-dosed controls. Horses in group 2 were given omeprazole paste orally at 4 mg/kg bodyweight (BW)/day from day 0 to day 27 and 2 mg/kg BW/day of omeprazole paste orally from day 28 to day 57. Follow-up endoscopies were conducted on post treatment days 28 and 58 or 59. Physical examinations, including BWs, were conducted on all horses prior to treatment and on days 13 or 14, 28, 42 or 43, and 58 or 59. Horses treated with omeprazole had significantly (P < 0.01) more improvement in gastric lesion scores than did controls at day 28 and at study termination on days 58 or 59. All of the omeprazole-treated horses were improved relative to baseline ulcer score at both examinations, and 73.3% were healed (lesion score of 0) at both examinations. None of the controls improved at any point during the study. When the dose was reduced to 2 mg/kg BW, 80% of the horses showed no recurrences or worsening in gastric ulcers. It was concluded that omeprazole paste at 4 mg/kg BW orally, once daily is highly effective in healing gastric ulcers in standardbred racehorses in training and that a dose of 2 mg/kg BW orally, once daily, effectively prevents the recurrence of gastric ulcers in most horses.
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Publication Date: 2003-08-02 PubMed ID: 12892289PubMed Central: PMC340210
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article examines the effectiveness of a paste formulation of the drug omeprazole on treating and preventing gastric ulcers in standardbred racehorses.

Participants and Study Design

  • The study involved twenty standardbred racehorses, aged between 2 to 9 years, which were selected from two training centres in Canada.
  • Endoscopic examinations were performed on these horses to confirm the presence of gastric ulcers. The ulcers were categorised based on severity from 0 to 3, where 0 represented an intact epithelium and 3 indicated extensive ulceration.
  • The horses were then grouped into two clusters based on their training level and location, with one horse assigned to group 1, which acted as the control group, and three horses assigned to group 2, which received the omeprazole treatment.

Treatment Process

  • The horses in group 2 were administered an oral dose of omeprazole paste at a rate of 4 mg/kg bodyweight (BW) daily from day 0 to day 27, and 2 mg/kg BW daily from day 28 to day 57.
  • Physical examinations and subsequent endoscopies were performed on all the horses at several intervals before and during the treatment process to monitor changes.

Results

  • The study found that the omeprazole treatment group showed a significantly greater reduction in gastric ulcer scores compared to the control group at day 28 and at the conclusion of the study on days 58 or 59.
  • At both examination intervals, all horses in the treatment group displayed an improvement in ulcer score from their baseline measurements.
  • Moreover, around 73.3% of horses in the omeprazole group showed complete healing (ulcer score of 0) at both examinations.
  • The control group, on the other hand, showed no signs of improvement during the entirety of the study.
  • The research noted that even when the dosage was reduced to 2 mg/kg BW, 80% of the horses did not show any reemergence or worsening of the gastric ulcers.

Conclusion

  • The study successfully proved that omeprazole paste administered at 4 mg/kg BW orally, once daily, was highly effective in curing gastric ulcers in standardbred racehorses undergoing training.
  • Furthermore, a reduced dose of 2 mg/kg BW, delivered daily, was found to effectively prevent the recurrence of gastric ulcers in most horses.

Cite This Article

APA
Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. (2003). Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J, 44(7), 581-585.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 44
Issue: 7
Pages: 581-585

Researcher Affiliations

Doucet, Michèle Y
  • Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, Saint-Hyacinthe, Québec J2S 7C6.
Vrins, André A
    Dionne, Rachel
      Alva, Roberto
        Ericsson, Glenn

          MeSH Terms

          • Administration, Oral
          • Animals
          • Anti-Ulcer Agents / therapeutic use
          • Dose-Response Relationship, Drug
          • Female
          • Gastroscopy / veterinary
          • Horse Diseases / drug therapy
          • Horse Diseases / prevention & control
          • Horses
          • Male
          • Ointments
          • Omeprazole / therapeutic use
          • Random Allocation
          • Recurrence
          • Stomach / pathology
          • Stomach Ulcer / drug therapy
          • Stomach Ulcer / prevention & control
          • Stomach Ulcer / veterinary
          • Treatment Outcome

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