Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training.
Abstract: To determine the minimal effective dosage of omeprazole oral paste for the prevention of naturally occurring ulcers in horses starting race training. Methods: Prospective study. Methods: 175 horses. Methods: Horses in the dose selection portion of the study were sham dose treated or received 1 mg (0.45 mg/lb) or 2 mg (0.9 mg/lb) of omeprazole/kg, PO, every 24 hours for 28 days or 4 mg of omeprazole/kg (1.8 mg/lb; loading dose), PO, every 24 hours for 4 days, then 1 or 2 mg of omeprazole/kg, PO, every 24 hours for 24 days. Horses in the dose confirmation portion of the study were sham dose treated or received 1 mg of omeprazole/kg, PO, every 24 hours for 28 days. Gastric ulcer scores at the beginning and end of the study were compared. Results: Sham-dose-treated horses had significantly higher ulcer scores than did horses treated with any of the omeprazole dosages evaluated. Among horses treated with omeprazole, there was no significant interaction of dose (1 or 2 mg/kg) and loading dose; therefore, the lowest effective dose (1 mg/kg) was evaluated in the dose confirmation portion of the study. In the dose confirmation study, 4 of 39 (10%) sham-dose-treated horses remained ulcer free, which was significantly different from the proportion of horses (31/38 [82%]) receiving 1 mg of omeprazole/kg that remained ulcer free. CONCLUSIONS AND CLINICAL RELEVANCE; Results indicated that omeprazole administered at a dosage of 1 mg/kg, PO, every 24 hours for 28 days was effective for prevention of gastric ulcers in horses starting race training.
Publication Date: 2005-05-24 PubMed ID: 15906568DOI: 10.2460/javma.2005.226.1681Google Scholar: Lookup
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- Clinical Trial
- Journal Article
- Multicenter Study
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research paper tests the minimum effective dosage of omeprazole oral paste for preventing ulcers in horses starting race training. The findings suggest that a dosage of 1 mg/kg every 24 hours for 28 days is effective for ulcer prevention.
Study Design and Methods
- The study is prospective and includes a total of 175 horses.
- Initially, horses were either given a sham dose, a dose of 1 mg (0.45 mg/lb), or a dose of 2 mg (0.9 mg/lb) of omeprazole per kg every 24 hours for 28 days, or a loading dose of 4 mg of omeprazole per kg for 4 days, followed by 1 or 2 mg of omeprazole per kg every 24 hours for the next 24 days.
- In the dose confirmation part of the study, horses either received a sham dose or a dose of 1 mg of omeprazole per kg every 24 hours for 28 days.
- Gastric ulcer scores of the horses were measured at the beginning and end of the study for comparison.
Results
- The study found that horses treated with a sham dose had significantly higher ulcer scores compared with those treated with any dosage of omeprazole.
- Among horses treated with omeprazole, the dose and the loading dose, whether 1 mg/kg or 2 mg/kg, did not significantly affect the results.
- The lowest effective dose (1 mg/kg) was then evaluated in the dose confirmation portion of the study.
- The study found that only 10% of horses treated with a sham dose remained ulcer-free, a significantly lower proportion compared with the 82% of horses receiving 1 mg of omeprazole per kg that remained ulcer-free.
Conclusions and Clinical Relevance
- The research concluded that administering omeprazole at a dosage of 1 mg/kg orally every 24 hours for 28 days is effective for preventing gastric ulcers in horses starting to train for racing.
Cite This Article
APA
McClure SR, White GW, Sifferman RL, Bernard W, Doucet MY, Vrins A, Holste JE, Fleishman C, Alva R, Cramer LG.
(2005).
Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training.
J Am Vet Med Assoc, 226(10), 1681-1684.
https://doi.org/10.2460/javma.2005.226.1681 Publication
Researcher Affiliations
- College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250,USA.
MeSH Terms
- Administration, Oral
- Animals
- Anti-Ulcer Agents / administration & dosage
- Dose-Response Relationship, Drug
- Female
- Horse Diseases / prevention & control
- Horses
- Male
- Ointments
- Omeprazole / administration & dosage
- Physical Conditioning, Animal / adverse effects
- Prospective Studies
- Stomach Ulcer / prevention & control
- Stomach Ulcer / veterinary
- Treatment Outcome
Citations
This article has been cited 5 times.- Shan R, Steel CM, Sykes B. The Impact of Two Recommended Withholding Periods for Omeprazole and the Use of a Nutraceutical Supplement on Recurrence of Equine Gastric Ulcer Syndrome in Thoroughbred Racehorses. Animals (Basel) 2023 May 31;13(11).
- Hwang H, Dong HJ, Han J, Cho S, Kim Y, Lee I. Prevalence and treatment of gastric ulcers in Thoroughbred racehorses of Korea. J Vet Sci 2022 Mar;23(2):e19.
- Cerri S, Taminiau B, de Lusancay AH, Lecoq L, Amory H, Daube G, Cesarini C. Effect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses. J Vet Intern Med 2020 Nov;34(6):2727-2737.
- Wise JC, Raidal SL, Wilkes EJA, Hughes KJ. Intragastric pH of foals admitted to the intensive care unit. J Vet Intern Med 2020 Nov;34(6):2719-2726.
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
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