Efficacy of two extra-label anthelmintic formulations against equine strongyles in Cuba.
Abstract: Equine cyathostomin parasites are ubiquitous in grazing horses and have been shown to cause severe inflammatory disease in the large intestine of horses. Decades of intensive anthelmintic therapy have led to widespread anthelmintic resistance in cyathostomins across the world. In Cuba, no anthelmintic products are formulated and sold for equine usage and little is known about anthelmintic efficacy of ruminant and swine formulations used. A strongyle fecal egg count reduction test was used to assess the efficacy of a liquid formulation of ivermectin labelled for use in swine, ruminants and carnivores and a pelleted formulation of albendazole labelled for usage in ruminants. Nine farms in the province Camagüey were enrolled in the study comprising 149 horses in total. Albendazole efficacy was reduced on five farms and with the other four farms having no signs of reduced efficacy. Mean farm efficacies were ranging from 41.7% to 100% on the tested farms. Coprocultures found large strongyle larvae present on all farms, but all larvae identified post-treatment were cyathostomins. Ivermectin was found 100% efficacious on all studied farms. This study provided evidence of reduced albendazole efficacy in the study population. Further work is needed to evaluate whether these findings reflect true resistance or if they are due to pharmacokinetic or pharmacodynamic characteristics of the pelleted formulation tested here.
Published by Elsevier B.V.
Publication Date: 2017-02-01 PubMed ID: 31014635DOI: 10.1016/j.vprsr.2017.01.010Google Scholar: Lookup
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- Journal Article
Summary
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This study examines the effectiveness of two types of deworming drugs not typically used for horses, but re-purposed from swine and ruminants, in combating equine strongyles (a type of parasite) in Cuba. The results indicate that one drug, ivermectin, was completely effective, while the other, albendazole, showed reduced effectiveness in some cases, warranting further investigation.
Background and Objectives
- The problem examined in this research revolves around the increasingly high resistance to deworming drugs among equine cyathostomin parasites, which are common in grazing horses and can cause severe intestinal diseases.
- Because Cuba does not sell anthelmintic products specifically for horses, the efficacy of swine and ruminant anthelmintic formulations was tested in this study.
Methodology
- The study made use of a fecal egg count reduction test to evaluate the effectiveness of a swine, ruminant, and carnivore formulation of ivermectin and a ruminant formulation of albendazole.
- Nine horse farms in Camagüey province, Cuba were involved, including a total of 149 horses.
Results
- The albendazole was less effective on five of the nine farms, while there were no detected signs of reduced efficacy on the remaining four farms. Depending on the farm, the efficacy ranged from 41.7% to 100%.
- Post-treatment testing found cyathostomin larvae on all farms. It is important to note that large strongyle larvae were detected on all farms before the treatment began.
- The ivermectin formulation was found to be completely effective on all farms, showing 100% efficacy.
Conclusions and Further Work
- The paper concludes that the ruminant and swine anthelmintic products had varying degrees of success. Ivermectin consistently showed full efficacy, while albendazole’s effectiveness was reduced in some cases.
- Further research is needed to determine whether the reduced efficacy of albendazole is due to true resistance in the parasites or whether it is related to the specific characteristics of the pelleted formulation used in this study.
Cite This Article
APA
Salas-Romero J, Gomez-Cabrera K, Molento MB, Lyons ET, Delgado A, González L, Arenal A, Nielsen MK.
(2017).
Efficacy of two extra-label anthelmintic formulations against equine strongyles in Cuba.
Vet Parasitol Reg Stud Reports, 8, 39-42.
https://doi.org/10.1016/j.vprsr.2017.01.010 Publication
Researcher Affiliations
- Faculty of Agricultural Sciences, University of Camagüey, Ignacio Agramonte Loynáz. Cuba. Carretera de Circunvalación Km 5 1/2, Camagüey 74 650, Cuba. Electronic address: josmel.salas@reduc.edu.cu.
- Faculty of Agricultural Sciences, University of Camagüey, Ignacio Agramonte Loynáz. Cuba. Carretera de Circunvalación Km 5 1/2, Camagüey 74 650, Cuba.
- Department of Veterinary Medicine, Federal University of Parana, Rua dos Funcionários, 1540 - Laboratório de Doenças Parasitárias, HV Juvevê, 80035-050 Curitiba, PR, Brasil.
- Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA.
- Faculty of Agricultural Sciences, University of Camagüey, Ignacio Agramonte Loynáz. Cuba. Carretera de Circunvalación Km 5 1/2, Camagüey 74 650, Cuba.
- Faculty of Agricultural Sciences, University of Camagüey, Ignacio Agramonte Loynáz. Cuba. Carretera de Circunvalación Km 5 1/2, Camagüey 74 650, Cuba.
- Faculty of Agricultural Sciences, University of Camagüey, Ignacio Agramonte Loynáz. Cuba. Carretera de Circunvalación Km 5 1/2, Camagüey 74 650, Cuba.
- Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA.
Citations
This article has been cited 1 times.- Buono F, Veneziano V, Veronesi F, Molento MB. Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections. Parasitology 2023 Oct;150(12):1119-1138.
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