Emergence from inhibited development of cyathostome larvae in ponies following failure to remove them by repeated treatments with benzimidazole compounds.
Abstract: The effect of three albendazole treatments at 5-week intervals, beginning at turnout in April, on cyathostome infections in Shetland ponies was compared with the effect of sequential treatments with albendazole, oxfendazole and oxibendazole. The results showed a substantial reduction in faecal egg output after the first albendazole treatment. Since faecal egg counts remained very low, no estimation of the effect of the second treatment was possible. The third treatment with albendazole and oxibendazole was followed by an increase in faecal egg counts to values of greater than 100 eggs g-1 within 4 weeks. A final albendazole treatment in December, 1 week before necropsy, failed to reduce faecal egg counts. These results suggest resistance to albendazole and oxibendazole in the cyathostome populations of the ponies. The increase in faecal egg counts after the third anthelmintic treatment in July occurred, although overwintered pasture infectivity was very low. The most likely explanation for this increase is resumption of the development of worms which overwintered as inhibited larvae in the host.
Publication Date: 1989-11-01 PubMed ID: 2588473DOI: 10.1016/0304-4017(89)90168-4Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article investigates the effectiveness of repeated benzimidazole treatments in regulating cyathostome infections in ponies, suggesting a possible resistance to these treatments due to persistent high levels of detected eggs.
Research Objective and Methodology
- The main objective of this study was to examine the effect of repeated treatments with albendazole, a type of benzimidazole compound, on the control of cyathostome infections in Shetland ponies. The study also aimed to compare the efficacy of three different treatments against cyathostome infections: albendazole, oxfendazole, and oxibendazole.
- The researchers administered the treatments in three doses at 5-week intervals, starting from April (turnout time). The response to treatment was assessed by measuring faecal egg output at each interval and comparing the fecal egg counts before and after treatment.
Research Findings
- The results demonstrated a notable decrease in faecal egg output following the first treatment with albendazole. However, due to the persistent low faecal egg counts, it was not feasible to estimate the impact of the second treatment.
- Interestingly, the third round of treatment was less successful. Even after administration of albendazole and oxibendazole, the researchers observed an increase in faecal egg counts within four weeks. Furthermore, a follow-up albendazole dose in December showed no impact on decreasing faecal egg counts.
- In summary, the study suggests probable resistance to albendazole and oxibendazole treatments among cyathostome populations infecting the ponies.
Resumption of Worm Development Theory
- The study also points out an interesting observation: the faecal egg count increased after the third treatment even when the pasture infectivity was very low.
- The researchers speculate that this increase in faecal egg count can be attributed to the comeback of the lifecycle of worms that were initially paused as inhibited larvae within the host.
- This implies the possible rebound of the worm development cycle, offering a plausible explanation for the failure of the treatment method.
Cite This Article
APA
Eysker M, Boersema JH, Kooyman FN.
(1989).
Emergence from inhibited development of cyathostome larvae in ponies following failure to remove them by repeated treatments with benzimidazole compounds.
Vet Parasitol, 34(1-2), 87-93.
https://doi.org/10.1016/0304-4017(89)90168-4 Publication
Researcher Affiliations
- Department of Infectious Diseases and Immunology, University of Utrecht, The Netherlands.
MeSH Terms
- Albendazole / administration & dosage
- Albendazole / therapeutic use
- Animals
- Anthelmintics / administration & dosage
- Anthelmintics / therapeutic use
- Benzimidazoles / administration & dosage
- Benzimidazoles / therapeutic use
- Drug Resistance
- Feces / parasitology
- Horses
- Larva / drug effects
- Larva / growth & development
- Male
- Parasite Egg Count / veterinary
- Strongyle Infections, Equine / drug therapy
- Strongyloidea / drug effects
- Strongyloidea / growth & development
Citations
This article has been cited 2 times.- Corning S. Equine cyathostomins: a review of biology, clinical significance and therapy. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S1.
- Traversa D, Iorio R, Klei TR, Kharchenko VA, Gawor J, Otranto D, Sparagano OA. New method for simultaneous species-specific identification of equine strongyles (nematoda, strongylida) by reverse line blot hybridization. J Clin Microbiol 2007 Sep;45(9):2937-42.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
