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Home / Equine Research Bank / Vet Res Commun / Endocannabinoid system and phytocannabinoids in the main spe...
Veterinary research communications2024; doi: 10.1007/s11259-024-10509-7

Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review.

Abstract: Since the discovery of the endocannabinoid system and due to the empirical evidence of the therapeutic effects on several illnesses both in humans and animals that follow the administration of exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed to identify the expression and distribution of cannabinoid receptors in healthy and pathologic organs and tissues of different animal species and to define the interactions of phytocannabinoids with these receptors. In the last decade, pharmacokinetics, efficacy and tolerability of many Cannabis derivatives formulations, mainly containing cannabidiol, in the main species of veterinary interest, have been also investigated. This manuscript summarizes the findings reported by the scientific studies published so far on the molecular mode of action of the main phytocannabinoids, the localization of cannabinoid receptors in organs and tissues, as well as the pharmacokinetics, efficacy and tolerability of Cannabis derivatives in dogs, cats, horses and other species of veterinary interest. A deep knowledge of these issues is crucial for the use of phytocannabinoids for therapeutic purposes in animal species.
© 2024. The Author(s).
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Publication Date: 2024-08-20 PubMed ID: 39162768PubMed Central: 8298633DOI: 10.1007/s11259-024-10509-7Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the studies conducted on the effects and interactions of cannabinoids (particularly the plant-derived variety known as phytocannabinoids) with the endocannabinoid system in animals. It provides an overview of the identified expression and distribution of cannabinoid receptors in healthy and pathological organs and tissues across several animal species, and presents data on the efficacy, tolerability, and pharmacokinetics of cannabis derivatives, primarily cannabidiol, within the main species of interest in veterinary medicine.

Endocannabinoid System and Phytocannabinoids

  • The endocannabinoid system (ECS) consists of cannabinoid receptors, endocannabinoids (naturally occurring cannabinoids in the body), and enzymes that regulate the synthesis and degradation of these endocannabinoids. This system has crucial roles in various physiological processes, such as pain sensation, mood, appetite, sleep, among others.
  • Phytocannabinoids are plant-derived cannabinoids, primarily sourced from Cannabis. This research focuses on the interaction of these exogenous cannabinoids with the endocannabinoid system within different animal species.

Expression and Distribution of Cannabinoid Receptors

  • The focus of many studies is to understand the presence (“expression”) and location (“distribution”) of cannabinoid receptors in both normal and transformed (pathogenic) animal organs and tissues. This helps researchers investigate how cannabinoids, both natural and plant-derived, can influence health and disease in animal models.

Pharmacokinetics, Efficacy, and Tolerability of Cannabis Derivatives

  • Pharmacokinetics deal with how drugs are absorbed, distributed, metabolized, and excreted by the body. The research discusses these aspects for cannabis derivatives, especially cannabidiol (CBD), in veterinary contexts. It is crucial to understand these parameters to optimize drug dosages and minimize the risk of adverse effects.
  • The efficacy of these exogenous cannabinoids in treating various illnesses in animals is also considered in these studies. Exploring this potentially therapeutic aspect is vital for developing and recommending effective veterinary treatments.
  • Tolerability pertains to the degree to which side effects can be tolerated by patients. If a veterinary drug is not well-tolerated, it will not be effective, regardless of its potential benefits. Therefore, it is equally important to investigate the effects of cannabis derivatives in terms of tolerability.

Conclusions and Future Directions

  • The article concludes by emphasizing the importance of this deep understanding of the endocannabinoid system and the interaction of phytocannabinoids with it for possible medical usage in animals. This knowledge can potentially lead to new, effective treatments for various ailments in animals.

Cite This Article

APA
Di Salvo A, Chiaradia E, Sforna M, Della Rocca G. (2024). Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review. Vet Res Commun. https://doi.org/10.1007/s11259-024-10509-7

Publication

Veterinary research communications
ISSN: 1573-7446
NlmUniqueID: 8100520
Country: Switzerland
Language: English

Researcher Affiliations

Di Salvo, Alessandra
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
  • Research Center on Animal Pain (CeRiDA), University of Perugia, Perugia, Italy.
Chiaradia, Elisabetta
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy. elisabetta.chiaradia@unipg.it.
Sforna, Monica
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
Della Rocca, Giorgia
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
  • Research Center on Animal Pain (CeRiDA), University of Perugia, Perugia, Italy.

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