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Endometrosis–significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods.
Abstract: Equine endometrosis is a multifactorial disease considered to be a one of the most important causes of equine infertility, especially in older mares. This article reviews the current knowledge of equine endometrosis: pathogenesis, diagnosis, and optional treatment. Also describes the histomorphological and immunohistochemical characterization of endometrosis as well as potential etiological factors which may influence disease progression. Unfortunately, the etiology and pathogenesis of endometrosis still remains unclear, and consequently no effective treatment has been proposed so far. Therefore future studies are needed for explanation of this disease.
Publication Date: 2014-10-08 PubMed ID: 25286671DOI: 10.2478/pjvs-2014-0083Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is centered on equine endometrosis, a disease that often leads to infertility in horses, especially older female horses. The paper discusses the causes, diagnosis, and potential treatment of the disease, noting that the path to fully understanding and treating the disease still requires further research.
Understanding Equine Endometrosis
- The focus of the research is equine endometrosis, a disease that largely affects the reproductive abilities of horses, specifically in older female horses (mares). This disease is considered one of the leading causes of infertility among these animals.
- The researchers discuss its multifactorial nature – that is, it is caused by multiple factors. Despite concentrated research, the etiology (origin or cause of the disease) and pathogenesis (the processes within the body that result in the development of the disease) remain unknown.
Methods of Diagnosing Equine Endometrosis
- The study reviews current diagnostic methods for identifying equine endometrosis. This includes understanding the physical manifestations of the disease (histomorphological characterization) and studying specific proteins that are indicative of the disease via immunohistochemical characterization.
- Despite its profound impact on horse reproduction, there are many uncertainties and complexities associated with correctly diagnosing equine endometrosis, which the research elaborates on.
Potential Treatments for Equine Endometrosis
- As the cause and progression of the disease remain largely unknown, developing an effective treatment has proven challenging. The absence of an effective treatment for equine endometrosis is highlighted in the research.
- Proposed treatment methods and their efficacy are discussed in the review. However, the study concludes with the understanding that more extensive research is needed to advance the explanation, diagnosis, and, ultimately, the treatment of this disease.
Future Studies on Equine Endometrosis
- The review highlights the need for future research to further understand equine endometrosis. This includes gaining deeper insight into its etiological factors and pathogenesis in order to develop effective treatments.
Cite This Article
APA
Buczkowska J, Kozdrowski R, Nowak M, Raś A, Mrowiec J.
(2014).
Endometrosis–significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods.
Pol J Vet Sci, 17(3), 547-554.
https://doi.org/10.2478/pjvs-2014-0083 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Endometriosis / pathology
- Endometriosis / therapy
- Endometriosis / veterinary
- Female
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses
Citations
This article has been cited 11 times.- Alpoim-Moreira J, Szóstek-Mioduchowska A, Słyszewska M, Rebordão MR, Skarzynski DJ, Ferreira-Dias G. 5-Aza-2'-Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III Expression in TGF-β1-Treated Equine Endometrial Fibroblasts. Animals (Basel) 2023 Mar 30;13(7).
- Alpoim-Moreira J, Fernandes C, Pimenta J, Bliebernicht M, Rebordão MR, Castelo-Branco P, Szóstek-Mioduchowska A, Skarzynski DJ, Ferreira-Dias G. Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis. Front Vet Sci 2022;9:970003.
- Amaral A, Fernandes C, Szóstek-Mioduchowska A, Lukasik K, Rebordão MR, Pinto-Bravo P, Skarzynski DJ, Ferreira-Dias G. The Inhibitory Effect of Noscapine on the In Vitro Cathepsin G-Induced Collagen Expression in Equine Endometrium. Life (Basel) 2021 Oct 19;11(10).
- Cequier A, Sanz C, Rodellar C, Barrachina L. The Usefulness of Mesenchymal Stem Cells beyond the Musculoskeletal System in Horses. Animals (Basel) 2021 Mar 25;11(4).
- Amaral A, Fernandes C, Morazzo S, Rebordão MR, Szóstek-Mioduchowska A, Lukasik K, Gawronska-Kozak B, Telo da Gama L, Skarzynski DJ, Ferreira-Dias G. The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare. Front Vet Sci 2020;7:582211.
- Schöniger S, Schoon HA. The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses. Animals (Basel) 2020 Apr 5;10(4).
- Méndez-Pérez L, Wong YS, Ibáñez BO, Martinez-Hormaza I, Rodríguez-Álvarez L, Castro FO. Bidirectional Interaction Between PGE(2)-Preconditioned Mesenchymal Stem Cells and Myofibroblasts Mediates Anti-Fibrotic Effects: A Proteomic Investigation into Equine Endometrial Fibrosis Reversal. Proteomes 2025 Sep 8;13(3).
- Piotrowska-Tomala KK, Szóstek-Mioduchowska AZ, Drzewiecka EM, Jonczyk AW, Wójtowicz A, Wrobel MH, Ferreira-Dias G, Skarzynski DJ. Prostaglandin pathways in equine myometrium regulations: endometrosis progression. Front Vet Sci 2024;11:1479508.
- Piotrowska-Tomala KK, Szóstek-Mioduchowska A, Jonczyk AW, Drzewiecka EM, Wrobel MH, Hojo T, Ferreira-Dias G, Skarzynski DJ. The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares. BMC Vet Res 2024 Dec 19;20(1):571.
- Wong YS, Mançanares AC, Navarrete F, Poblete P, Mendez-Pérez L, Cabezas J, Riadi G, Rodríguez-Alvarez L, Castro FO. Extracellular vesicles secreted by equine adipose mesenchymal stem cells preconditioned with transforming growth factor β-1 are enriched in anti-fibrotic miRNAs and inhibit the expression of fibrotic genes in an in vitro system of endometrial stromal cells fibrosis. Vet Q 2024 Dec;44(1):1-11.
- Wong YS, Mançanares AC, Navarrete FI, Poblete PM, Méndez-Pérez L, Ferreira-Dias GML, Rodriguez-Alvarez L, Castro FO. Mare stromal endometrial cells differentially modulate inflammation depending on oestrus cycle status: an in vitro study. Front Vet Sci 2023;10:1271240.
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