Enilconazole treatment of horses with superficial Aspergillus spp. rhinitis.
Abstract: Mycotic rhinitis is an uncommon disease in horses with a wide range of clinical signs and treatment options based on case studies of a single or only a few individuals. Moreover, while dogs with mycotic rhinitis appear to respond well to treatment with topical enilconazole, this approach has yet to be reported in horses. Objective: The aim of this study was to describe the clinical findings, results of diagnostic investigations, treatment, and outcome in horses with mycotic rhinitis treated with topical enilconazole. Methods: Eight horses were included in the study. Methods: Medical records from 1995 to 2007 from an equine veterinary teaching hospital were reviewed to identify cases with a diagnosis of mycotic rhinitis. Results: Eleven cases were identified, of which 8 were treated with topical enilconazole. Seven of those 8 horses recovered and had normal appearance of the nasal passages on endoscopic examination. Fungal culture, where positive, yielded only Aspergillus spp. Treatment was readily performed and no adverse effects were noted in these horses. In 5 horses, long-term follow-up revealed complete recovery for an average of 5 years. Conclusions: Mycotic rhinitis owing to Aspergillus spp. in horses can be effectively and safely treated with topical enilconazole.
Publication Date: 2008-10-11 PubMed ID: 18844830DOI: 10.1111/j.1939-1676.2008.0173.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research investigates the use of enilconazole in treating mycotic rhinitis in horses, caused by the fungus Aspergillus spp., with promising recovery outcomes noted.
Introduction and Objective
This study focused on understanding the effects of treating mycotic rhinitis, a rare fungal disease in horses, with the dependable antifungal, enilconazole. Up until the point of research, enilconazole had proven to be an effective treatment for mycotic rhinitis in dogs, though its usage in horses remained unrecorded.
Methods and Sample Size
The researchers worked with eight horses for this study.
- The medical records spanning between 1995 to 2007 were garnered from an equine veterinary teaching hospital.
- Horses with a medical history of mycotic rhinitis were identified and chosen.
- The chosen patients were treated with topical enilconazole.
Results and Observations
- Eleven cases of mycotic rhinitis were identified, out of which eight were selected for treatment with enilconazole.
- Seven out of the eight horses showed recovery, with normal nasal passage appearances in endoscopic examinations.
- Aspergillus spp., a type of fungus, was the only positive culture seen in the subjected fungal culture.
- The treatment process was easily carried out with zero negative side effects observed.
- Long-term follow-up was conducted on five horses, which indicated complete recovery over an average span of five years.
Conclusion
Mycotic Rhinitis caused by Aspergillus spp. in horses can be successfully and safely treated with topical enilconazole. This study conclusively paves the way for the approved use of enilconazole in equine medical treatment, affirming its effectiveness and safety.
Cite This Article
APA
Kendall A, Bröjer J, Karlstam E, Pringle J.
(2008).
Enilconazole treatment of horses with superficial Aspergillus spp. rhinitis.
J Vet Intern Med, 22(5), 1239-1242.
https://doi.org/10.1111/j.1939-1676.2008.0173.x Publication
Researcher Affiliations
- University Hospital of the Swedish University of Agricultural Sciences, Uppsala, Sweden. anna.kendall@kv.slu.se
MeSH Terms
- Administration, Topical
- Animals
- Antifungal Agents / administration & dosage
- Antifungal Agents / therapeutic use
- Aspergillosis / veterinary
- Horse Diseases / drug therapy
- Horses
- Imidazoles / administration & dosage
- Imidazoles / therapeutic use
- Retrospective Studies
- Rhinitis / drug therapy
- Rhinitis / microbiology
- Rhinitis / veterinary
Citations
This article has been cited 4 times.- Whitehead AE, Whitty J, Scott M, Léguillette R. Reversible dysphagia secondary to guttural pouch mycosis in a gelding treated medically with voriconazole and surgically with carotid occlusion and esophagostomy. Can Vet J 2018 Feb;59(2):165-170.
- Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
- de Moura Alonso J, Watanabe MJ, de Moraes Gimenes Bosco S, Apolonio EVP, de Vasconcelos AB, do Prado AC, Alves ALG, Rodrigues CA, Hussni CA. Treatment of mycotic rhinitis caused by aspergillus fumigatus in a quarter horse mare using topical clotrimazole and oral potassium iodide. Vet Res Commun 2024 Nov 22;49(1):28.
- Portaels J, Van Crombrugge E, Van Den Broeck W, Lagrou K, Laval K, Nauwynck H. Aspergillus Fumigatus Spore Proteases Alter the Respiratory Mucosa Architecture and Facilitate Equine Herpesvirus 1 Infection. Viruses 2024 Jul 27;16(8).
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