Equine abortion and premature birth associated with Cellulosimicrobium cellulans infection.
Abstract: During the 2002 and 2003 foaling seasons, Cellulosimicrobium (Cellumonas) cellulans (formerly Oerskovia xanthineolytica) was the principal microorganism isolated from fetal tissues or placentas from cases of equine abortion, premature birth, and term pregnancies. Significant pathologic findings included chronic placentitis and pyogranulomatous pneumonia. In addition, microscopic and macroscopic alterations in the allantochorion from 4 of 7 cases of placentitis were similar to those caused by Crossiella equi and other nocardioform bacteria. This report confirms a causative role of C. cellulans infection in equine abortion.
Publication Date: 2004-08-13 PubMed ID: 15305747DOI: 10.1177/104063870401600414Google Scholar: Lookup
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- Journal Article
Summary
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The research investigates the role of a specific bacterium, Cellulosimicrobium cellulans, in causing issues in horse pregnancies, notably premature birth and abortion. The findings indicate a significant correlation between the presence of this bacteria and these equine pregnancy complications.
Background
- Cellulosimicrobium cellulans is a type of bacterium that was primarily identified in equine fetal tissues during the 2002 and 2003 foaling (horse birthing) seasons.
- Historically, this microorganism was known as Oerskovia xanthineolytica.
- The research primarily focuses on its impact on horse pregnancies, particularly in causing premature births and abortions.
Key Findings
- Significant pathologic observations involved chronic inflammation of the placenta (chronic placentitis) and pus-forming granulated inflammation in the lung tissue (pyogranulomatous pneumonia).
- Cellulosimicrobium cellulans was the main microorganism isolated in instances of premature birth, abortion, and full-term pregnancies indicating its pervasive role in equine pregnancies.
Allantochorion Alterations
- Besides the pathologic findings, there were alterations in the allantochorion, a portion of the placenta in horses, observed in 4 of the 7 cases of placentitis.
- These alterations were both microscopic and macroscopic and bore similarities with the changes caused by Crossiella equi and other bacteria from the nocardioform group.
Implications of the Research
- The study confirmed the causative role of C. cellulans infection in equine abortion, indicating that controlling this bacteria’s prevalence may reduce such pregnancy complications in horses.
- The findings offer significant potential for improved prevention and treatment strategies for equine prenatal care.
Cite This Article
APA
Bolin DC, Donahue JM, Vickers ML, Giles RC, Harrison L, Jackson C, Poonacha KB, Roberts JE, Sebastian MM, Sells SE, Tramontin R, Williams NM.
(2004).
Equine abortion and premature birth associated with Cellulosimicrobium cellulans infection.
J Vet Diagn Invest, 16(4), 333-336.
https://doi.org/10.1177/104063870401600414 Publication
Researcher Affiliations
- Livestock Disease Diagnostic Center, College of Agriculture, University of Kentucky, Lexington, KY 40511-4125, USA.
MeSH Terms
- Abortion, Veterinary / microbiology
- Animals
- Female
- Gram-Negative Bacterial Infections / complications
- Gram-Negative Bacterial Infections / veterinary
- Horse Diseases / microbiology
- Horses
- Obstetric Labor, Premature / microbiology
- Obstetric Labor, Premature / veterinary
- Placenta Diseases / microbiology
- Placenta Diseases / veterinary
- Pneumonia, Bacterial / veterinary
- Pregnancy
Citations
This article has been cited 4 times.- Zhao Y, Sun J, Ding M, Hayat Khattak R, Teng L, Liu Z. Growth Stages and Inter-Species Gut Microbiota Composition and Function in Captive Red Deer (Cervus elaphus alxaicus) and Blue Sheep (Pseudois nayaur). Animals (Basel) 2023 Feb 4;13(4).
- Aviles FA, Kyndt JA. Cellulosimicrobium fucosivorans sp. nov., isolated from San Elijo Lagoon, contains a fucose metabolic pathway linked to carotenoid production. Arch Microbiol 2021 Sep;203(7):4525-4538.
- Tuon T, Souza PS, Santos MF, Pereira FT, Pedroso GS, Luciano TF, De Souza CT, Dutra RC, Silveira PC, Pinho RA. Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson's Disease. Oxid Med Cell Longev 2015;2015:261809.
- Wildman DE, Uddin M, Romero R, Gonzalez JM, Than NG, Murphy J, Hou ZC, Fritz J. Spontaneous abortion and preterm labor and delivery in nonhuman primates: evidence from a captive colony of chimpanzees (Pan troglodytes). PLoS One 2011;6(9):e24509.
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