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Home / Equine Research Bank / J Vet Pharmacol Ther / Equine antimicrobial therapy: Current and past issues facing...
Journal of veterinary pharmacology and therapeutics2021; 44(2); 270-279; doi: 10.1111/jvp.12964

Equine antimicrobial therapy: Current and past issues facing practitioners.

Abstract: Equine antimicrobial therapy has advanced over time with the availability of increasing pharmacokinetic and pharmacodynamic studies in horses, allowing for greater evidence-based clinical decision-making. However, many challenges to optimal antimicrobial therapy remain and further research is needed to address these areas. There are a limited number of approved antimicrobials for use in horses, which creates a need for compounded preparations for clinicians. Extra-label drug use is commonplace in equine practice, which warrants continual education of veterinarians about policies and updates. Performance and competitive horses have their own unique concerns when it comes to antimicrobial use and drug testing. In keeping with the use of a broader range of antimicrobials over time, antimicrobial resistance is emerging as an important issue facing veterinary medicine, including equine practice. Another challenge is that of drug interactions and adverse drug events for which there are little scientific data available for horses, especially for critically important diseases such as Rhodococcus equi infection. Finally, much progress has been made in the availability of equine-specific antimicrobial susceptibility break points. These aid clinicians in interpreting culture and susceptibility results and antimicrobial selection. Even with these advances, continuing education and further research are needed in this area.
© 2021 John Wiley & Sons Ltd.
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Publication Date: 2021-03-02 PubMed ID: 33650183DOI: 10.1111/jvp.12964Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses about the evolution and challenges in equine antimicrobial therapy. The paper covers topics such as antimicrobial resistance, lack of approved antimicrobials for use in horses, use of unconventional drugs, and the need for further research and education in this field.

Advancements in Equine Antimicrobial Therapy

  • The study begins by acknowledging the progress that has been made in the field of equine antimicrobial therapy. The authors note that this progress has come about due to an increase in pharmacokinetic and pharmacodynamic studies, which have allowed for more evidence-based clinical decision making in veterinary practice.

Challenges in Antimicrobial Therapy

  • The paper highlights several challenges faced by practitioners of equine antimicrobial therapy. One of these challenges relates to the limited number of approved antimicrobials for use in horses, which can necessitate the use of compounded preparations and create a need for more research in this area.
  • The authors also discuss the common practice of using extra-label drugs in equine treatment, which implies a need for continual education of veterinarians to remain updated about relevant policies and guidelines.
  • Another concern described in the article is the unique issues that arise in the treatment of performance and competitive horses. These may relate to antimicrobial use and drug testing rules under various sporting bodies.

Antimicrobial Resistance

  • A significant issue brought up in the study is the growing problem of antimicrobial resistance. The paper highlights that as greater variety of antimicrobials have been used, resistance has emerged as an important challenge in veterinary medicine, including equine practice.
  • Furthermore, the authors point to the lack of scientific data available on drug interactions and adverse drug events in horses, particularly for critical diseases such as Rhodococcus equi infection.

Future Directions in Equine Antimicrobial Therapy

  • The research acknowledges the progress made in the availability of equine-specific antimicrobial susceptibility breakpoints. These provide great help to clinicians in interpreting culture and susceptibility results as well as in selecting suitable antimicrobials.
  • However, the paper concludes by emphasizing the need for further research in this field to overcome the current limitations and challenges. It also underscores the importance of continuous education for practitioners to keep up with the latest advancements in equine antimicrobial therapy.

Cite This Article

APA
Knych HK, Magdesian KG. (2021). Equine antimicrobial therapy: Current and past issues facing practitioners. J Vet Pharmacol Ther, 44(2), 270-279. https://doi.org/10.1111/jvp.12964

Publication

Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 44
Issue: 2
Pages: 270-279

Researcher Affiliations

Knych, Heather K
  • Kenneth L. Maddy Equine Analytical Pharmacology Laboratory and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA.
Magdesian, K Gary
  • Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.

MeSH Terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Horse Diseases / drug therapy
  • Horses
  • Humans
  • Veterinarians

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Citations

This article has been cited 7 times.
  1. Rockow M, Griffenhagen G, Landolt G, Hendrickson D, Pezzanite L. Current Antimicrobial Use in Horses Undergoing Exploratory Celiotomy: A Survey of Board-Certified Equine Specialists. Animals (Basel) 2023 Apr 22;13(9).
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