Equine atypical myopathy: a review.
Abstract: Atypical myopathy (AM) is an acute rhabdomyolysis syndrome that occurs at irregular intervals in grazing equines. An increasing number of outbreaks have been reported in recent years, including some from countries where the disease has not previously been diagnosed. In this review, clinical and other details of outbreaks of AM are analysed to better define its epidemiological profile. Potential aetiologies are discussed, the short clinical course of AM is described and the main biochemical and pathological findings are considered. Recommendations for medical management are suggested, based on a review of clinical reports. Biochemical and histopathological findings have been integrated in order to characterise the physiopathology of AM. There is an ongoing requirement to record new cases of this syndrome, ideally through an epidemiological network.
Publication Date: 2008-03-28 PubMed ID: 18375157DOI: 10.1016/j.tvjl.2008.02.004Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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The research aims to further understand Atypical Myopathy (AM), a severe muscle disease in horses, by examining past outbreaks and their clinical details to define AM’s epidemiological profile. The paper also discusses potential causes, describes its progression, presents biochemical and pathological findings, and provides suggestions for medical management.
Epidemiological Profile of AM
- The study looks at past outbreaks of Atypical Myopathy (AM) in grazing equines. It tries to define the epidemiological profile of AM by evaluating the locations of these outbreaks, frequency, and the type of horses most affected.
- The research also shows that there’s been an increase in the number of outbreaks, even in countries where the disease had not been previously diagnosed. This element highlights the spreading of the disease and its expansion into new territories.
Potential Aetiologies
- The paper discusses potential causes of AM but does not provide definitive answers. It seems to suggest that understanding the origins and triggers of the disorder is still an ongoing scientific endeavor.
- It highlights the importance of identifying factors contributing to the disease in enhancing prevention efforts and treatment options.
Clinical Course of AM
- The research describes the short clinical course of AM, which presumably entails a rapid onset and progression. This information is crucial for practitioners who may encounter the disease in their patients.
- Fast progression can complicate treatment and prognosis, emphasising the need for effective early diagnosis strategies.
Biochemical and Pathological Findings
- Biochemical and pathological findings are presented to better understand the disease’s effects on a molecular and bodily level. Such information helps practitioners identify the disease and choose appropriate treatment strategies.
- The researchers integrate these findings to characterise the physiopathology of AM, seeking a more holistic understanding of how the disease functions and impacts the horse’s body.
Medical Management and The Way Forward
- Based on a review of clinical reports, the research suggests recommendations for managing AM medically. However, these are not explicitly mentioned here in the abstract. They may involve treatment strategies, preventive measures, or protocols for managing horses with AM.
- The abstract ends by highlighting the ongoing need to record new cases of AM, ideally through an established epidemiological network. This statement underscores the importance of continued surveillance and data collection in research and prevention efforts against AM.
Cite This Article
APA
Votion DM, Serteyn D.
(2008).
Equine atypical myopathy: a review.
Vet J, 178(2), 185-190.
https://doi.org/10.1016/j.tvjl.2008.02.004 Publication
Researcher Affiliations
- Equine Teaching Hospital, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium. dominique.votion@ulg.ac.be
MeSH Terms
- Animals
- Disease Outbreaks / veterinary
- Fluid Therapy / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / etiology
- Horse Diseases / therapy
- Horses
- Rhabdomyolysis / epidemiology
- Rhabdomyolysis / etiology
- Rhabdomyolysis / therapy
- Rhabdomyolysis / veterinary
- Selenium / therapeutic use
- Vitamins / therapeutic use
References
This article includes 32 references
Citations
This article has been cited 6 times.- Aboling S. Do Poisonous Plants in Pastures Communicate Their Toxicity? Meta-Study and Evaluation of Poisoning Cases in Central Europe. Animals (Basel) 2023 Dec 8;13(24).
- Jahn P, Dobešová D, Brumarová R, Tóthová K, Kopecká A, Friedecký D. Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy. Vet Q 2022 Dec;42(1):183-191.
- Wimmer-Scherr C, Taminiau B, Renaud B, van Loon G, Palmers K, Votion D, Amory H, Daube G, Cesarini C. Comparison of Fecal Microbiota of Horses Suffering from Atypical Myopathy and Healthy Co-Grazers. Animals (Basel) 2021 Feb 15;11(2).
- Quattrocelli M, Giacomazzi G, Broeckx SY, Ceelen L, Bolca S, Spaas JH, Sampaolesi M. Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates. Stem Cell Reports 2016 Jan 12;6(1):55-63.
- Bochnia M, Ziegler J, Sander J, Uhlig A, Schaefer S, Vollstedt S, Glatter M, Abel S, Recknagel S, Schusser GF, Wensch-Dorendorf M, Zeyner A. Hypoglycin A Content in Blood and Urine Discriminates Horses with Atypical Myopathy from Clinically Normal Horses Grazing on the Same Pasture. PLoS One 2015;10(9):e0136785.
- Votion DM. The story of equine atypical myopathy: a review from the beginning to a possible end. ISRN Vet Sci 2012;2012:281018.
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