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Cytogenetic and genome research2008; 120(1-2); 42-49; doi: 10.1159/000118739

Equine clinical cytogenetics: the past and future.

Abstract: Cytogenetic analyses of horses have benefited the horse industry by identifying chromosomal aberrations causing congenital abnormalities, embryonic loss and infertility. Technical advances in cytogenetics enabled the identification of chromosome specific aberrations. More recently, advances in genomic tools have been used to more precisely define chromosome abnormalities. In this report we review the history of equine clinical cytogenetics, identify historical landmarks for equine clinical cytogenetics, discuss how the current use of genomic tools has benefited this area, and how future genomics tools may enhance clinical cytogenetic studies in the horse.
Publication Date: 2008-04-30 PubMed ID: 18467824DOI: 10.1159/000118739Google Scholar: Lookup
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Summary

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The research article discusses the historical development, current applications, and future directions of clinical cytogenetics in the horse industry. It underscores the crucial role it played in diagnosing chromosomal aberrations resulting in congenital abnormalities, embryonic loss, and infertility.

Historical landmarks in equine clinical cytogenetics

The article gives a chronological review of the progress of equine clinical cytogenetics:

  • First, the authors discuss how cytogenetic analyses of horses have contributed greatly to the horse industry. This is through the identification of chromosomal aberrations that are the underlying causes of various problems such as congenital abnormalities, embryonic loss, and infertility.
  • Furthermore, they highlight the role of evolving technology in chromosomal diagnosis. Earlier, generic chromosomal aberrations were detected. However, as technology advanced, it became possible to identify specific chromosomal aberrations, greatly enhancing the accuracy and efficiency of diagnosis.

The present scenario of equine clinical cytogenetics

After providing a historical overview, the authors delve into the current state of equine clinical cytogenetics and how modern tools have revolutionized this field:

  • The authors highlight how recent advancements in genomic tools have immensely improved the precision of chromosomal abnormalities. These tools enabled a more detailed examination of the chromosomes, thus offering a more definitive understanding of the genetic conditions in horses.

The future potential of equine clinical cytogenetics

Looking forward, the article discusses potential future advancements in equine clinical cytogenetics:

  • The authors project that upcoming genomic tools might greatly enhance clinical cytogenetic studies in horses. With the continuous progress of technology, more refined and sophisticated genomic tools will become available. These tools will facilitate more in-depth analysis and precise detection of even slight abnormalities in the horse’s chromosomes.

In conclusion, this article provides a comprehensive overview of the evolution, the present impact, and future potential of cytogenetic studies in horses. It emphasizes the great value and significant potential of this field in enhancing the health and productivity of the horse industry.

Cite This Article

APA
Lear TL, Bailey E. (2008). Equine clinical cytogenetics: the past and future. Cytogenet Genome Res, 120(1-2), 42-49. https://doi.org/10.1159/000118739

Publication

ISSN: 1424-859X
NlmUniqueID: 101142708
Country: Switzerland
Language: English
Volume: 120
Issue: 1-2
Pages: 42-49

Researcher Affiliations

Lear, T L
  • M.H. Gluck Equine Research Center, Veterinary Science Department, University of Kentucky, Lexington, KY, USA. equigene@uky.edu
Bailey, E

    MeSH Terms

    • Aneuploidy
    • Animals
    • Chromosome Aberrations / veterinary
    • Chromosome Deletion
    • Cytogenetic Analysis / history
    • Cytogenetic Analysis / trends
    • Cytogenetic Analysis / veterinary
    • Cytogenetics / history
    • Cytogenetics / trends
    • Disorders of Sex Development
    • Female
    • Genomics / history
    • Genomics / trends
    • History, 20th Century
    • History, 21st Century
    • Horse Diseases / genetics
    • Horses / genetics
    • Male
    • Sex Chromosome Aberrations / veterinary
    • Translocation, Genetic
    • Trisomy
    • Veterinary Medicine / history
    • Veterinary Medicine / trends

    Citations

    This article has been cited 8 times.
    1. Ghosh S, Kjöllerström J, Metcalfe L, Reed S, Juras R, Raudsepp T. The Second Case of Non-Mosaic Trisomy of Chromosome 26 with Homologous Fusion 26q;26q in the Horse.. Animals (Basel) 2022 Mar 22;12(7).
      doi: 10.3390/ani12070803pubmed: 35405793google scholar: lookup
    2. Bugno-Poniewierska M, Raudsepp T. Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings.. Animals (Basel) 2021 Mar 16;11(3).
      doi: 10.3390/ani11030831pubmed: 33809432google scholar: lookup
    3. Laseca N, Anaya G, Peña Z, Pirosanto Y, Molina A, Demyda Peyrás S. Impaired Reproductive Function in Equines: From Genetics to Genomics.. Animals (Basel) 2021 Feb 3;11(2).
      doi: 10.3390/ani11020393pubmed: 33546520google scholar: lookup
    4. Villagomez DAF, Welsford EG, King WA, Revay T. Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome.. Genes (Basel) 2020 Jan 10;11(1).
      doi: 10.3390/genes11010078pubmed: 31936796google scholar: lookup
    5. Baily MP, Avila F, Das PJ, Kutzler MA, Raudsepp T. An Autosomal Translocation 73,XY,t(12;20)(q11;q11) in an Infertile Male Llama (Lama glama) With Teratozoospermia.. Front Genet 2019;10:344.
      doi: 10.3389/fgene.2019.00344pubmed: 31040865google scholar: lookup
    6. Holl HM, Lear TL, Nolen-Walston RD, Slack J, Brooks SA. Detection of two equine trisomies using SNP-CGH.. Mamm Genome 2013 Jun;24(5-6):252-6.
      doi: 10.1007/s00335-013-9450-6pubmed: 23515943google scholar: lookup
    7. Avila F, Das PJ, Kutzler M, Owens E, Perelman P, Rubes J, Hornak M, Johnson WE, Raudsepp T. Development and application of camelid molecular cytogenetic tools.. J Hered 2014 Nov-Dec;105(6):858-69.
      doi: 10.1093/jhered/ess067pubmed: 23109720google scholar: lookup
    8. Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer.. Equine Vet J 2010 Oct;42(7):658-70.