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Home / Equine Research Bank / Vet Dermatol / Equine Cutaneous Lymphoma: A Case Report.
Veterinary dermatology1995; 6(2); 105-111; doi: 10.1111/j.1365-3164.1995.tb00051.x

Equine Cutaneous Lymphoma: A Case Report.

Abstract: Résumé- Les commémoratifs, les symptômes, l'histologie et la réponse au traitement d'un cheval de 15 ans atteint de lymphome cutané sont décrits. La jument présente de multiples nodules cutanés depuis 11 ans. Un diagnostic de lymphome cutané est poséà l'examen histologique de biopsies réalisées 2 fois à 4 ans d'intervalle. Des marquages immunihistochimiques identifient ces cellules comme appartenant à la lignée T. Ceci est la première description du marquage immunophénotypique d'un lymphome cutané chez le cheval. La jument a été traitée par des glucorticoïdes intralésionnels et des progestagènes oraux ce qui a entrainé une régression complète des nodules. Resumen- Describimos la historia clinica y los hallazgos clinicos e histológicos de un caballo de 15 años con un linfoma cutáneo. La yegua tenia una historia clinica de multiples nédules cutáneos en los últimos 11 años. Se diagnosticó un linfoma cutáneo mediante estudio histológico de dos biosias tomadas con unos cuatro años de separación. Tinciones inmunohistoquimicas ulteriores identificaron la linea celular de ünfocitos T. Este es el primer estudio que caracteriza el linfoma equino a nivel inmunofenotipico. La yegua fue tratada con glucocorticoides intralesionales y progestágenos orales, lo que resultó en curación total de los nódulos. Abstract- The history, clinical and histological features and response to treatment of a 15-year-old horse with cutaneous lymphoma are described. The mare had an 11 year history of multiple cutaneous nodules. A diagnosis of cutaneous lymphoma was made on histological examination of biopsy material taken on two separate occasions some 4 years apart. Subsequent immunohistochemical staining identified the cell lineage as T-lymphocytes. This is the first report of immunophenotypic characterisation of cutaneous lymphoma in the horse. The horse was treated with intralesional glucocorticoids and oral progestins, and complete resolution of the nodules resulted.
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Publication Date: 1995-06-01 PubMed ID: 34644860DOI: 10.1111/j.1365-3164.1995.tb00051.xGoogle Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research provides a detailed case study of a 15-year-old horse affected by cutaneous lymphoma, where clinical features, histological examination, and treatment response were scrutinized. This is the first instance where an immunophenotypic characterization of cutaneous lymphoma in horses is reported.

Case Description and Diagnosis

  • The study revolves around a 15-year-old mare that had been showing signs of cutaneous lymphoma for the past 11 years, signaled by the presence of multiple skin nodules.
  • A diagnosis of cutaneous lymphoma was ultimately reached based on a histological examination of biopsied tissue, which was sampled twice across a span of four years.

Immunophenotypic Characterization

  • Further analysis provided a deeper insight into the nature of the disease. Through immunohistochemical staining, the cells were identified as T-lymphocytes, a type of white blood cell crucial to the immune system.
  • This identification holds significance as it is the first reported instance of such a detailed characterisation of cutaneous lymphoma in horses.

Treatment and Results

  • The treatment protocol defined for this case included using intralesional glucocorticoids and oral progestins.
  • These treatment measures proved to be successful, as they led to the complete resolution of the nodules, indicating a total remediation of the lymphoma.

Cite This Article

APA
Littlewood JD, Whitwell KE, Day MJ. (1995). Equine Cutaneous Lymphoma: A Case Report. Vet Dermatol, 6(2), 105-111. https://doi.org/10.1111/j.1365-3164.1995.tb00051.x

Publication

Veterinary dermatology
ISSN: 1365-3164
NlmUniqueID: 9426187
Country: England
Language: English
Volume: 6
Issue: 2
Pages: 105-111

Researcher Affiliations

Littlewood, Janet D
  • *Centre for Small Animal Studies, Animal Health Trust, P.O. Box 5, Newmarket, Suffolk CB8 7DW, U.K.
  • ‡Centre for Preventive Medicine, Animal Health Trust, P.O. Box 5, Newmarket, Suffolk CB8 7DW, U.K.
Whitwell, Katherine E
  • ‡Centre for Preventive Medicine, Animal Health Trust, P.O. Box 5, Newmarket, Suffolk CB8 7DW, U.K.
Day, Michael J
  • §Department of Pathology and Microbiology, Comparative Pathology Laboratory, School of Veterinary Science, Langford, Bristol BS18 7DU, U.K.

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Citations

This article has been cited 2 times.
  1. Kondratjeva J, Julien F, Coutelier C, Humeau L, Moog F, Combarros D, Fourquaux I, Pressanti C, Delverdier M, Moore PF, Cadiergues MC. Cutaneous epitheliotropic T-cell lymphoma in a donkey - a case report. BMC Vet Res 2022 Jul 11;18(1):267.
    doi: 10.1186/s12917-022-03365-7pubmed: 35821128google scholar: lookup
  2. Doyle AJ, MacDonald VS, Bourque A. Use of lomustine (CCNU) in a case of cutaneous equine lymphoma. Can Vet J 2013 Dec;54(12):1137-41.
    pubmed: 24293673
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