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Home / Equine Research Bank / Virology / Equine herpes viruses.
Virology1963; 19; 412-416; doi: 10.1016/0042-6822(63)90083-7

Equine herpes viruses.

Abstract: No abstract available
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Publication Date: 1963-03-01 PubMed ID: 13944111DOI: 10.1016/0042-6822(63)90083-7Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the discovery of a new virus in horses, called the LK virus, that bears similarities to the herpes group of viruses. The researchers also compared it to another equine virus which causes abortion in horses. They observed the effect of these viruses on rabbit kidney tissue and performed electron microscopy to view them at a molecular level.

Comparative Study of Equine Viruses

  • The researchers identified a new equine virus, called the LK virus, during their studies on equine respiratory diseases. The virus was isolated from a horse that showed symptoms indicative of upper respiratory infection.
  • They found that the LK virus shared many of the characteristics typical to the herpes group of viruses.
  • Simultaneously, the researchers conducted parallel investigations of another equine virus that causes abortion in horses, sometimes referred to as ‘rhinopneumonitis’.
  • The team discovered marked similarities between the LK virus and the equine abortion virus, despite the two viruses being distinct serologically (recognizable by the immune system).

Effects on Rabbit Kidney Tissue

  • Both viruses were observed to cause a cytopathic effect, meaning they altered the functions of the rabbit kidney cells causing them to round and balloon in shape. Some syncytium or cell fusion formation was also noticed.
  • Upon staining the infected cells with haematoxylin and eosin, they found type A intranuclear inclusions. These are markers commonly associated with viral infections.

Varying Clinical Reactions

  • The LK virus did not cause any visible symptoms or lesions when inoculated in different parts of a rabbit’s body. Similarly, no symptoms were observed in suckling mice inoculated intracerebrally (injected into the brain).
  • In contrast, the equine abortion virus caused local skin inflammation in rabbits following intradermal (within skin) inoculation. It also caused the death of suckling mice following intracerebral inoculation and produced pocks or marks on chick embryos.

Electron Microscopy of the Viruses

  • To visualize the viruses, the researchers conducted electron microscopy of the tissue culture fluid containing the viruses. Various stages of centrifugation and resuspension were carried out to prepare the virus solution.
  • The solution was then mixed with potassium phosphotungstate and sprayed onto carbon-coated grids for processing and visualization under the microscope.

Cite This Article

APA
PLUMMER G, WATERSON AP. (1963). Equine herpes viruses. Virology, 19, 412-416. https://doi.org/10.1016/0042-6822(63)90083-7

Publication

Virology
ISSN: 0042-6822
NlmUniqueID: 0110674
Country: United States
Language: English
Volume: 19
Pages: 412-416

Researcher Affiliations

PLUMMER, G
    WATERSON, A P

      MeSH Terms

      • Animals
      • Herpesviridae
      • Horses

      Citations

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