Equine histoplasmosis: treatment trial in cart horses in Central Ethiopia.
- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This study investigates the effectiveness of various treatments on equine histoplasmosis, a disease affecting horses, in Ethiopia. It found statistically significant differences in efficacy among the treatments, with certain combinations showing significant improvement in disease conditions.
Introduction
The study revolves around Equine Histoplasmosis (EH), a fungal disease that affects horses. This research takes place in Central Ethiopia, focusing on cart horses. The primary intent of the study is to evaluate the therapeutic effects of various treatments on EH.
Treatments Tested
- Sodium Iodide (NaI)
- Potassium Iodide (KI)
- Ground berries of “Endod” (Phytolacca dodecandra), a plant used in traditional medicine
- Penstrip, an antibiotic drug
Methodology
The researchers tested the aforementioned treatments on 70 cases of EH. They assessed each case’s response to the treatments through a clinical examination of the disease lesions.
Findings
The findings suggest a statistically significant difference (P = 0.0036) in the therapeutic effects of the various treatments. The researchers found that cart horses treated with either a combination of Sodium Iodide (NaI) and Penstrip (F = 6.34, P = 0.004) or ground berries of “Endod” (Phytolacca dodecandra) and Penstrip (F = 3.64, P = 0.031) demonstrated a significant response to the therapy.
Treatment Effect on Early Vs. Advanced EH
The researchers also examined the difference in response to the treatments between early and advanced cases of EH. The results showed a statistically significant (t = 2.22, P = 0.0148) difference, implying that the stage of the disease could impact the effectiveness of the treatment, though the abstract doesn’t provide detailed information about this finding.
Conclusion
This research presents valuable findings about the effectiveness of different treatments for EH in horses. Particularly, it highlights the potential significantly positive effects of combining certain treatments. It also suggests the disease stage might affect the treatment response, hinting that early intervention might be more beneficial. However, further details would need to be explored in the complete study.
Cite This Article
Publication
Researcher Affiliations
- Faculty of Veterinary sciences, Mekelle University, P.O. BOX 231, Mekelle, Ethiopia. bselam12@yahoo.com
MeSH Terms
- Animals
- Histoplasma / growth & development
- Histoplasmosis / drug therapy
- Histoplasmosis / microbiology
- Histoplasmosis / pathology
- Histoplasmosis / veterinary
- Horse Diseases / drug therapy
- Horse Diseases / microbiology
- Horse Diseases / pathology
- Horses
- Penicillin G Procaine / therapeutic use
- Phytolacca dodecandra
- Phytotherapy / veterinary
- Potassium Iodide / therapeutic use
- Sodium Iodide / therapeutic use
References
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Citations
This article has been cited 5 times.- Duguma BE, Tesfaye T, Kassaye A, Kassa A, Blakeway SJ. Control and Prevention of Epizootic Lymphangitis in Mules: An Integrated Community-Based Intervention, Bahir Dar, Ethiopia.. Front Vet Sci 2021;8:648267.
- Molla AM, Fentahun T, Jemberu WT. Estimating the Economic Impact and Assessing Owners' Knowledge and Practices of Epizootic Lymphangitis in Equine Cart Animals in Central and South Gondar Zones, Amhara Region, Ethiopia.. Front Vet Sci 2021;8:673442.
- Hadush B, Michaelay M, Menghistu HT, Abebe N, Genzebu AT, Bitsue HK, Afera B, Duguma BE, Gugsa G, Ameni G. Epidemiology of epizootic lymphangitis of carthorses in northern Ethiopia using conventional diagnostic methods and nested polymerase chain reaction.. BMC Vet Res 2020 Oct 7;16(1):375.
- Mekonnen N, Makonnen E, Aklilu N, Ameni G. Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum var. farciminosum and treatment of cases of epizootic lymphangitis in Ethiopia.. Asian Pac J Trop Biomed 2012 Jul;2(7):505-10.
- Taye B, Giday M, Animut A, Seid J. Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia.. Asian Pac J Trop Biomed 2011 Oct;1(5):370-5.
