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Home / Equine Research Bank / J Vet Emerg Crit Care (San Antonio) / Equine inflammatory response to abdominal surgery in the abs...
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)2021; 31(5); 601-607; doi: 10.1111/vec.13092

Equine inflammatory response to abdominal surgery in the absence of gastrointestinal disease.

Abstract: To investigate the, equine inflammatory response to ventral midline celiotomy in the absence of gastrointestinal disease in horses of varying body condition scores primarily using serial measurements of serum amyloid A (SAA). Methods: Experimental clinical study. Methods: University teaching hospital. Methods: Ten adult light breed horses free of any clinical disease, 5 with body condition score (BCS) 3-4/9 and 5 with BCS 7-8/9. Methods: Horses had a ventral midline celiotomy performed under general anesthesia, including manual decompression of the small intestine. SAA, semiquantitative fibrinogen, plasma lactate, and WBC count were measured in the blood preoperatively and at 12, 24, 48, 72, 120, and 168 hours postoperatively. Complete serum biochemistry was performed preoperatively and 24 and 72 hours postoperatively. Serial abdominocentesis was also performed with peritoneal fluid analysis of SAA, total protein, lactate, WBC count, and cytology. Results: Significant (P < 0.05) increases in serum SAA were noted at 12, 24, and 48 hours postoperatively (124.6 ± 68.6, 390.8 ± 209.0, 568.6 ± 197.7 μg/mL), and most horses had values approaching normal at 168 hours postoperatively (174.4 ± 307.7 μg/mL). Other values such as fibrinogen also increased in response to surgery but did not return to normal within the measured time points. Horses with high BCS did not have significantly different serum SAA compared to horses with low BCS. Peritoneal fluid SAA did not increase significantly at 12 hours postoperatively. Conclusions: The information from this study can be used to help determine the effect of anesthesia and surgical intestinal manipulation resulting in increased SAA when a comparison to clinical or experimental cases is needed.
© Veterinary Emergency and Critical Care Society 2021.
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Publication Date: 2021-07-01 PubMed ID: 34196457DOI: 10.1111/vec.13092Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates how horses with different body conditions react to abdominal surgery, focusing primarily on the changes in levels of Serum Amyloid A (SAA), a marker of inflammation.

Experimental Design

  • The study was conducted at a University teaching hospital.
  • A group of ten adult light-breed horses in good health was chosen for the study. Half of the horses had a body condition score (BCS) of 3-4 out of 9, and the other half had a BCS of 7-8 out of 9.
  • All horses underwent ventral midline celiotomy (abdominal surgery) under general anesthesia. This process also included manual decompression of the small intestine.
  • Samples for SAA, semiquantitative fibrinogen (a blood clotting factor), plasma lactate, and white blood cell (WBC) count were collected before the surgery and again at regular intervals up to 168 hours post-surgery.
  • A complete serum biochemistry was also performed before surgery and at 24 and 72 hours after surgery.
  • Finally, serial abdominocentesis (sampling of the fluid in the abdominal cavity) was performed and its content analyzed for SAA, total protein, lactate, WBC count, and cytology.

Main Findings

  • Significant increases in serum SAA were noted at 12, 24, and 48 hours post-surgery. By 168 hours post-surgery, the SAA levels in most horses were almost back to normal.
  • Other parameters, such as fibrinogen, also increased in response to surgery but did not return to pre-surgery values within the duration of the study.
  • No difference was noted in these responses between horses with high BCS and low BCS.
  • There was no significant increase in peritoneal fluid SAA at 12 hours after surgery.

Conclusions

  • The study provides valuable data for understanding how anesthesia and surgical procedures affect the levels of SAA in the horse’s body. This information can be crucial when comparing with clinical or experimental cases where increased SAA level is observed.

Cite This Article

APA
Bowlby C, Mudge M, Schroeder E, Godman J, Hurcombe S. (2021). Equine inflammatory response to abdominal surgery in the absence of gastrointestinal disease. J Vet Emerg Crit Care (San Antonio), 31(5), 601-607. https://doi.org/10.1111/vec.13092

Publication

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
ISSN: 1476-4431
NlmUniqueID: 101152804
Country: United States
Language: English
Volume: 31
Issue: 5
Pages: 601-607

Researcher Affiliations

Bowlby, Charles
  • Department of Animal Sciences, The Ohio State University, Columbus, Ohio, USA.
Mudge, Margaret
  • Department of Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Schroeder, Eric
  • Department of Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Godman, Jennifer
  • Department of Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Hurcombe, Samuel
  • Department of Clinical Studies, University of Pennsylvania Kennett Square, Pennsylvania, USA.

MeSH Terms

  • Animals
  • Ascitic Fluid
  • Fibrinogen
  • Gastrointestinal Diseases / veterinary
  • Horse Diseases / surgery
  • Horses
  • Serum Amyloid A Protein

References

This article includes 21 references
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