Equine juvenile mandibular ossifying fibroma.
Abstract: Benign proliferative fibro-osseous lesions of the rostral mandible in six young horses are classified as equine juvenile mandibular ossifying fibroma. Histologically there is a characteristic abrupt transition from subgingival fibroblastic stroma to a zone of proliferating osteoblasts that form irregular spicules of osteoid. The layer of proliferating osteoblasts blends with a deeper zone of bony trabeculae rimmed by osteoblasts and separated by intertrabecular spaces of moderate cellular density. Incomplete surgical excision resulted in local recurrence, while rostral mandibulectomies resulted in no recurrence. The predilection for the rostral mandible of young horses coupled with the similar clinical, radiographic, and histological characteristics supports the classification of this lesion as a distinct entity.
Publication Date: 1988-11-01 PubMed ID: 3212886DOI: 10.1177/030098588802500603Google Scholar: Lookup
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- Journal Article
Summary
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The research identifies an equine juvenile mandibular ossifying fibroma, seen as benign growths in the front part of the lower jawbone in young horses. Complete removal of the affected bone portion proved effective in preventing recurrence, signifying the disease to be a unique medical condition due to its prevalence in a specific location amongst young horses and its consistent clinical, X-ray and microscopic features.
Understanding Equine Juvenile Mandibular Ossifying Fibroma
- Equine juvenile mandibular ossifying fibroma is a benign fibro-osseous growth seen in the anterior (or front) section of the lower jawbone in young horses.
- The tumor is characterized by a rapid transition from gum tissue to a region of proliferating osteoblasts—cells responsible for bone development, which form abnormal spikes of unripe bone tissue.
- At the deeper layers of the lesion, the proliferating osteoblasts merge into areas of bony meshwork, encased by more osteoblasts and separated by areas of moderate cell density.
Findings from the Research
- The growth was found to recur when surgery did not entirely remove it, while complete removal of the affected portion of the mandible resulted in no resurgence of the tumor.
- The study considered the recurrent occurrence of the disease in the rostral mandible of young horses noteworthy. The consistency in its clinical manifestations, radiographic evidence, and histologic characteristics further affirmed the uniqueness of this medical condition.
- The research thus postulates this lesion as a distinct entity that requires specialized examination for accurate diagnosis and subsequent effective treatment.
Implication of the Study
- With its unique set of characteristics, the correct diagnosis of equine juvenile mandibular ossifying fibroma becomes essential in the field of veterinary medicine, particularly equine health.
- The recurrence of the fibroma upon incomplete surgical removal necessitates thorough elimination during the surgical process.
- Better understanding and awareness of this specific fibroma in young horses can aid in the development of effective therapies, ensuring improved animal health and welfare.
Cite This Article
APA
Morse CC, Saik JE, Richardson DW, Fetter AW.
(1988).
Equine juvenile mandibular ossifying fibroma.
Vet Pathol, 25(6), 415-421.
https://doi.org/10.1177/030098588802500603 Publication
Researcher Affiliations
- Laboratory of Large Animal Pathology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square.
MeSH Terms
- Animals
- Female
- Fibroma / pathology
- Fibroma / surgery
- Fibroma / veterinary
- Horse Diseases / pathology
- Horse Diseases / surgery
- Horses
- Male
- Mandibular Neoplasms / pathology
- Mandibular Neoplasms / surgery
- Mandibular Neoplasms / veterinary
- Osteoma / pathology
- Osteoma / surgery
- Osteoma / veterinary
- Recurrence
Citations
This article has been cited 10 times.- Turek B, Górski K, Drewnowska O, Buczkowska R, Kozłowska N, Sapierzyński R. Ossifying Fibroma in the Nasal Cavity of a 2-Year-Old Horse. Animals (Basel) 2021 Jan 27;11(2).
- Leitzen E, Stumpf S, Zimmermann C, Bienert-Zeit A, Hellige M, Baumgärtner W, Puff C. A Rare Case of Vascular Proliferation in the Mandible of a Juvenile Horse. Front Vet Sci 2020;7:573540.
- Zürcher-Giovannini S, Ruder TD, Pool R, Erdelyi K, Origgi FC. Mandibular Ossifying Fibroma and Multiple Oral Papillomas in a Roe Deer (Capreolus capreolus). Front Vet Sci 2020;7:166.
- Poore LA, Duncan N, Williams J. Unilateral subcutaneous fibroma in the distal femoral region of a 5-year-old Nooitgedacht mare. J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e4.
- Kodaira K, Muranaka M, Naito H, Ode H, Oku K, Nukada T, Katayama Y. Histopathological characteristics of an ossifying fibroma formed in the maxilla of a racehorse. J Equine Sci 2010;21(1):7-10.
- Bajpai M, Goel P, Bhutia O, Gupta A, Seth A, Gupta AK, Pawar DK. Massive ossifying fibroma of the mandible in a child. J Indian Assoc Pediatr Surg 2013 Jan;18(1):20-2.
- Schmelting B, Zöller M, Kaspareit J. Peripheral ossifying fibroma and juxtacortical chondrosarcoma in cynomolgus monkeys (Macaca fascicularis). J Am Assoc Lab Anim Sci 2011 Jan;50(1):98-104.
- Robbins SC, Arighi M, Ottewell G. The use of megavoltage radiation to treat juvenile mandibular ossifying fibroma in a horse. Can Vet J 1996 Nov;37(11):683-4.
- Pop R, Tăbăran AF, Vasiu I, Milgram J, Ober CA. Surgical management of ossifying fibroma in a 9-year-old Hungarian Vizsla: a case report and review of the literature. Front Vet Sci 2024;11:1497077.
- Cavasani JPDS, Dos Santos ÍG, Garcia DM, Olaya CEB, de Queiroz AA, Néspoli PEB, Souza MA, Colodel EM. Mandibular ossifying fibroma in 2 cattle in Brazil. J Vet Diagn Invest 2025 Mar;37(2):367-370.
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