Equine laminitis: a potential model of Raynaud’s phenomenon.
Abstract: Raynaud's phenomenon (RP) and equine laminitis in the horse are medical enigmas. Clinical and scientific data were compared to evaluate the degree of similarity that exists between these two peripheral vascular diseases. Data indicate that certain pathologic and pharmacologic aspects seem to have common features. Some of the correlations maybe due simply to both diseases having ischemia of the distal digits as a pathologic component. The exact etiology of the ischemia is not known for either disease. The results of this study suggest the hypothesis that RP and laminitis are the same disease in different species. This hypothesis can be tested more efficiently when the pathophysiology of both conditions is better documented. It is possible that comparative studies will promote advances in the understanding of both RP and laminitis. The fact that equine laminitis can be experimentally induced is of potential value in such future studies.
Publication Date: 1990-04-01 PubMed ID: 2339825DOI: 10.1177/000331979004100403Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article suggests a potential correlation between Raynaud’s phenomenon (RP), a human disease, and equine laminitis, a disease affecting horses. The study emphasizes the similarities between the two diseases and hypothesizes that they may be the same ailment manifesting in different species.
Comparison of Raynaud’s Phenomenon and Equine Laminitis
- This study compared clinical and scientific data on two diseases: Raynaud’s Phenomenon (RP), a human vascular disease whose sufferers experience episodes of reduced blood flow to the digits, and Equine Laminitis, a disease in horses that leads to inflammation of their feet.
- The research indicates that both diseases share common characteristics, especially in their pathologic and pharmacologic aspects. Both conditions exhibit ischemia (insufficient blood supply) in the distal digits, or the extremities such as fingers or toes in humans, and hoofs in horses.
Lack of Definite Cause of Ischemia in Both Diseases
- The cause of ischemia in both RP and equine laminitis, which is a key component in their pathology, remains unknown. Despite this lack of information, the existence of ischemia and the symptoms it causes draw a parallel between these two diseases.
- This led the researchers to propose a hypothesis suggesting that RP and laminitis might be the identical diseases, only manifested in different species, humans and horses respectively.
Further Testing and Possible Benefits
- The article indicates this hypothesis needs more comprehensive testing which would become more streamlined as the understanding of the pathophysiology of both these conditions improves.
- There’s huge potential in studying these two diseases in tandem. Comparative studies could lead to breakthroughs in understanding both RP and laminitis. Not only would the findings enhance understanding and treatment of the comparable disease in the other species, but they might also help reveal the underlying causes and mechanisms in each disease.
- A point of particular interest is that equine laminitis can be induced for experimental purposes. This clearly offers potential benefits in future research, presenting a means to directly observe and study the disease, which might lead to faster, more effective research and discoveries about both conditions.
Cite This Article
APA
Hood DM, Amoss MS, Grosenbaugh DA.
(1990).
Equine laminitis: a potential model of Raynaud’s phenomenon.
Angiology, 41(4), 270-277.
https://doi.org/10.1177/000331979004100403 Publication
Researcher Affiliations
- Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station.
MeSH Terms
- Adolescent
- Animals
- Disease Models, Animal
- Female
- Hoof and Claw / physiopathology
- Horse Diseases / pathology
- Horse Diseases / physiopathology
- Horses
- Humans
- Male
- Raynaud Disease / pathology
- Raynaud Disease / physiopathology
Citations
This article has been cited 3 times.- Lancaster LS, Bowker RM. Acupuncture Points of the Horse's Distal Thoracic Limb: A Neuroanatomic Approach to the Transposition of Traditional Points. Animals (Basel) 2012 Sep 17;2(3):455-71.
- Pawson P, Reid J, Nolan AM. The role of nitric oxide in the responses of the ovine digital artery to vasoactive agents and modification of these responses by endotoxin and cytokines. Br J Pharmacol 2000 May;130(1):109-17.
- Finding EJT, Faulkner A, Nash L, Wheeler-Jones CPD. Equine Endothelial Cells Show Pro-Angiogenic Behaviours in Response to Fibroblast Growth Factor 2 but Not Vascular Endothelial Growth Factor A. Int J Mol Sci 2024 May 30;25(11).
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