FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Equine Vet J / Equine leucocyte antigens in sarcoid-affected horses.
Equine veterinary journal1985; 17(4); 283-286; doi: 10.1111/j.2042-3306.1985.tb02498.x

Equine leucocyte antigens in sarcoid-affected horses.

Abstract: The distribution of equine leucocyte antigens (ELA) in horses affected by equine sarcoid tumours was determined and compared with unaffected controls. ELA-haplotype W3,B1 occurred more frequently in affected riding horses of Irish, Swiss and French background. The combined data for the three breeds resulted in a chi 2 value of 20.35 (P less than 0.0005 after correction). Simultaneously, ELA-specificity W11 was more frequently found in horses of Irish background, while W5 was found in Swiss and French horses with sarcoids. The combined data for haplotype W3,B1 and/or W5 specificity demonstrated, in the genetically closely-related Swiss and French horses, a highly significant difference in the occurrence of these haplotypes between affected horses and healthy controls (chi 2 = 28.69, P less than 0.00001 after correction). Thus, the results strongly suggest that the predisposition of horses to sarcoid is associated with or linked to the major histocompatibility complex.
Get Full Text
Publication Date: 1985-07-01 PubMed ID: 3865769DOI: 10.1111/j.2042-3306.1985.tb02498.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article talks about how certain types of horse leukocyte antigens (ELA), specifically ELA-haplotype W3,B1, W11 and W5, are more frequently found in horses that suffer from equine sarcoid tumors. These findings suggest that the development of this disease might be linked to the horse’s major histocompatibility complex.

Background and Objective

  • This research is focused on the role of equine leucocyte antigens (ELA) in the development of equine sarcoid tumors, which are skin cancer in horses.
  • ELA are proteins existing on the surface of horse cells that are crucial in the immune system defense against diseases and tumors.
  • The researchers aimed to determine the distribution of ELA in horses with sarcoid tumors and compare it with healthy horses.

Methodology

  • The researchers took riding horses of Irish, Swiss, and French backgrounds for this study. They divided the horses into two groups: those with equine sarcoid tumors and those without.
  • The occurrence of specific types of ELA (namely ELA-haplotype W3,B1, W11, and W5) were studied in both groups.

Findings

  • It was found that ELA-haplotype W3,B1 was present more frequently in horses with sarcoids across all three breeds.
  • In Irish horses, ELA-specificity W11 was more commonly found in those with sarcoids, whereas W5 was more prevalent in Swiss and French horses with the disease.
  • When the data for ELA-haplotype W3,B1 and/or W5 were combined, a noticeable difference in the occurrence of these specificities was detected between the affected horses and healthy controls. This was particularly true for the genetically closely-related Swiss and French horses.

Research Conclusion

  • The analysis strongly suggests that horse predisposition towards developing sarcoid tumors is potentially linked to their major histocompatibility complex, which means the disease could have some connection to the immune response of horses.
  • The presence of specific ELA types can be indicative of a horse’s susceptibility to develop equine sarcoid tumors.
  • This research could contribute to a better understanding of sarcoid tumors in horses and may help in finding effective prevention or treatment methods in the future.

Cite This Article

APA
Lazary S, Gerber H, Glatt PA, Straub R. (1985). Equine leucocyte antigens in sarcoid-affected horses. Equine Vet J, 17(4), 283-286. https://doi.org/10.1111/j.2042-3306.1985.tb02498.x

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 17
Issue: 4
Pages: 283-286

Researcher Affiliations

Lazary, S
    Gerber, H
      Glatt, P A
        Straub, R

          MeSH Terms

          • Animals
          • Female
          • Histocompatibility Antigens Class II / immunology
          • Horse Diseases / immunology
          • Horses
          • Leukocytes / immunology
          • Major Histocompatibility Complex
          • Male
          • Sarcoidosis / immunology
          • Sarcoidosis / veterinary
          • Skin Diseases / immunology
          • Skin Diseases / veterinary

          Citations

          This article has been cited 11 times.
          1. Pimenta J, Cotovio M. Equine Veterinarian Perspectives on Mucocutaneous Tumors in Horses: A Survey-Based Study in Portugal. Animals (Basel) 2025 Jun 23;15(13).
            doi: 10.3390/ani15131853pubmed: 40646752google scholar: lookup
          2. Quatember H, Nell B, Richter B, Rigler D, Dolezal M, Sykora S, Wallner B. Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid. Animals (Basel) 2025 Mar 22;15(7).
            doi: 10.3390/ani15070911pubmed: 40218305google scholar: lookup
          3. Brosnahan MM, Brooks SA, Antczak DF. Equine clinical genomics: A clinician's primer. Equine Vet J 2010 Oct;42(7):658-70.
            doi: 10.1111/j.2042-3306.2010.00166.xpubmed: 20840582google scholar: lookup
          4. Nappert G, Lavoie JP, Sauvageau R, Scott DW. Le sarcoïde équin: présentation d'un cas clinique. Can Vet J 1989 Nov;30(11):897-9.
            pubmed: 17423459
          5. Bogaert L, Van Poucke M, De Baere C, Peelman L, Gasthuys F, Martens A. Selection of a set of reliable reference genes for quantitative real-time PCR in normal equine skin and in equine sarcoids. BMC Biotechnol 2006 Apr 27;6:24.
            doi: 10.1186/1472-6750-6-24pubmed: 16643647google scholar: lookup
          6. Reid SW, Mohammed HO. Longitudinal and cross-sectional studies to evaluate the risk of sarcoid associated with castration. Can J Vet Res 1997 Apr;61(2):89-93.
            pubmed: 9114958
          7. Otten N, von Tscharner C, Lazary S, Antczak DF, Gerber H. DNA of bovine papillomavirus type 1 and 2 in equine sarcoids: PCR detection and direct sequencing. Arch Virol 1993;132(1-2):121-31.
            doi: 10.1007/BF01309847pubmed: 8394687google scholar: lookup
          8. Broström H. Equine sarcoids. A clinical and epidemiological study in relation to equine leucocyte antigens (ELA). Acta Vet Scand 1995;36(2):223-36.
            doi: 10.1186/BF03547691pubmed: 7484549google scholar: lookup
          9. Meredith D, Elser AH, Wolf B, Soma LR, Donawick WJ, Lazary S. Equine leukocyte antigens: relationships with sarcoid tumors and laminitis in two pure breeds. Immunogenetics 1986;23(4):221-5.
            doi: 10.1007/BF00373016pubmed: 3699852google scholar: lookup
          10. Müller M, Brem G. Disease resistance in farm animals. Experientia 1991 Sep 15;47(9):923-34.
            doi: 10.1007/BF01929883pubmed: 1915776google scholar: lookup
          11. Angelos JA, Marti E, Lazary S, Carmichael LE. Characterization of BPV-like DNA in equine sarcoids. Arch Virol 1991;119(1-2):95-109.
            doi: 10.1007/BF01314326pubmed: 1650553google scholar: lookup
          Subscribe to our newsletter
          Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.