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Home / Equine Research Bank / Immunogenetics / Equine leukocyte antigens: relationships with sarcoid tumors...
Immunogenetics1986; 23(4); 221-225; doi: 10.1007/BF00373016

Equine leukocyte antigens: relationships with sarcoid tumors and laminitis in two pure breeds.

Abstract: Frequencies of equine leukocyte antigen distribution were determined by complement-mediated cytotoxicity testing among populations of Thoroughbred and Standardbred horses, including animals affected with equine sarcoid and laminitis. A highly significant association is described between the presence or history of sarcoid lesions in Thoroughbreds and the expression of the major histocompatibility complex (MHC)-encoded antigens, W3 and B1. No association was found between antigenic expression frequencies and laminitis in either breed. These findings suggest that a strong relationship exists between the equine MHC and a predisposition to sarcoid.
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Publication Date: 1986-01-01 PubMed ID: 3699852DOI: 10.1007/BF00373016Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explored the connection between the presence of specific equine leukocyte antigens and the prevalence of sarcoid tumors and laminitis in Thoroughbred and Standardbred horses. The study found a significant association between the expression of the W3 and B1 antigens and the presence or historical occurrence of sarcoid lesions, but found no link to laminitis.

Research Objective and Methods Used

  • The primary aim of this research study was to understand the relationship of equine leukocyte antigens (immune system proteins in horses) with the occurrence of sarcoid tumors and laminitis across two specific breeds of horse – Thoroughbred and Standardbred.
  • The researchers used a technique known as complement-mediated cytotoxicity testing to determine the frequencies of equine leukocyte antigen distribution among these populations of horses.
  • The study included horses that were affected with either equine sarcoid (a skin tumor condition commonly seen in horses) and laminitis (a painful condition affecting the horse’s feet).

Key Findings

  • The key finding of this study is that a highly significant association existed between the presence or history of sarcoid lesions in Thoroughbreds and the expression of specific antigens, W3, and B1, which are encoded by the major histocompatibility complex (MHC). MHC is a group of genes that are crucial to the immune system’s recognition and response to foreign pathogens.
  • However, no association was found between the presence of these antigens and the occurrence of laminitis in either Thoroughbred or Standardbred horses.

Implications of the Research

  • The results of this study suggest that there might be a strong genetic component, specifically related to the equine MHC and its antigens, playing a role in predisposing certain breeds of horses to sarcoid tumors.
  • The absence of an association between these antigens and laminitis suggests that the progression of this condition could be influenced by factors other than the expression of MHC-encoded antigens.

Conclusion

  • The insights from this study have potential importance in understanding equine health, particularly in terms of identifying genetic markers that could potentially pre-dispose certain horses to developing specific health problems like sarcoid tumors.

Cite This Article

APA
Meredith D, Elser AH, Wolf B, Soma LR, Donawick WJ, Lazary S. (1986). Equine leukocyte antigens: relationships with sarcoid tumors and laminitis in two pure breeds. Immunogenetics, 23(4), 221-225. https://doi.org/10.1007/BF00373016

Publication

Immunogenetics
ISSN: 0093-7711
NlmUniqueID: 0420404
Country: United States
Language: English
Volume: 23
Issue: 4
Pages: 221-225

Researcher Affiliations

Meredith, D
    Elser, A H
      Wolf, B
        Soma, L R
          Donawick, W J
            Lazary, S

              MeSH Terms

              • Animals
              • Antigens, Surface / classification
              • Antigens, Surface / genetics
              • Antigens, Surface / immunology
              • Female
              • Gene Frequency
              • Horse Diseases / genetics
              • Horse Diseases / immunology
              • Horses / immunology
              • Leukocytes / immunology
              • Male
              • Sarcoidosis / immunology
              • Sarcoidosis / veterinary

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              This article includes 17 references
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              Citations

              This article has been cited 0 times.
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