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Digestive diseases and sciences1994; 39(12); 2530-2535; doi: 10.1007/BF02087686

Equine model of inducing ulceration in alimentary squamous epithelial mucosa.

Abstract: Ulceration of the gastric squamous epithelial mucosa was induced in 10 horses using a feeding protocol previously shown to expose the gastric mucosa to repeated periods of high acidity. The feeding protocol consisted of alternating feed deprivation with free access to hay. Over a period of seven days, each horse was provided hay for 84 hr and deprived of hay for 84 hr. Hay was never withheld for longer than 24 hr at a time. Gastroscopy was performed on each horse at the beginning of the protocol after 12 hr of feed deprivation, and after a total of 36 hr, 60 hr, and 84 hr of feed deprivation. All horses had normal esophageal and gastric mucosa at the beginning of the protocol. Alternating periods of feeding and feed deprivation resulted in progressive ulceration of the gastric squamous epithelial mucosa in all but one of the horses. Lesions progressed from erosions to ulceration within 36-72 hr of feed deprivation, and by 84 hr of feed deprivation ulcers had developed thickened, raised margins. Esophageal mucosa appeared normal in all horses throughout the study. The protocol of alternating feeding with feed deprivation in horses consistently produced gastric squamous epithelial ulceration and provided a useful model for characterizing temporal transitions in peptic-injured alimentary squamous epithelia.
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Publication Date: 1994-12-01 PubMed ID: 7995175DOI: 10.1007/BF02087686Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper examines a study where ulcers were induced in the gastric squamous epithelial mucosa of horses using a feeding protocol that alternates periods of feeding and food deprivation. The findings show that this model consistently produced the ulcers and can be useful for examining changes in this type of mucosa.

Research Methodology

  • This research involved a total of ten horses which were subjected to a feeding protocol designed to induce ulceration in their gastric squamous epithelial mucosa.
  • The feeding protocol included periods of feeding and periods of food deprivation alternately implemented. Specifically, throughout a week, each horse was given hay for 84 hours and was deprived of hay for the same length of time. In this process, hay deprivation was never done for longer than 24 hours at a stretch.
  • Each horse underwent gastroscopy at the beginning of the protocol, this was done after the horse had been subjected to 12 hours of feed deprivation. The gastroscopy was further performed after a cumulative duration of 36 hours, 60 hours, and 84 hours of feed deprivation.

Findings and Results

  • All horses had normal esophageal and gastric mucosa at the start of the protocol. However, as the protocol progressed, it was observed that the alternating feeding and food deprivation caused a gradual ulceration of the gastric squamous epithelial mucosa in all but one horse.
  • In the process, lesions progressed from erosions to full ulceration within a span of 36 – 72 hours of deprived feeding. After a total of 84 hours of food deprivation, the ulcers had developed thickened, raised margins.
  • Interestingly, despite the ulceration in the gastric squamous epithelial mucosa, the esophageal mucosa remained normal in all horses.

Conclusion

  • The article concludes that a feeding deprivation protocol in horses is effective in inducing ulceration in the gastric squamous epithelial mucosa.
  • This model not only consistently produced gastric squamous epithelial ulceration but also provided a useful template for characterizing the temporal changes that occur in peptic-injured alimentary squamous epithelia.

Cite This Article

APA
Murray MJ. (1994). Equine model of inducing ulceration in alimentary squamous epithelial mucosa. Dig Dis Sci, 39(12), 2530-2535. https://doi.org/10.1007/BF02087686

Publication

Digestive diseases and sciences
ISSN: 0163-2116
NlmUniqueID: 7902782
Country: United States
Language: English
Volume: 39
Issue: 12
Pages: 2530-2535

Researcher Affiliations

Murray, M J
  • Marion duPont Scott Equine Medical Center, Leesburg, Virginia 22075.

MeSH Terms

  • Animal Feed
  • Animals
  • Female
  • Food Deprivation
  • Gastric Mucosa / pathology
  • Gastroesophageal Reflux / etiology
  • Gastroesophageal Reflux / pathology
  • Gastroscopy
  • Horses
  • Male
  • Stomach Ulcer / etiology
  • Stomach Ulcer / pathology
  • Time Factors

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This article includes 22 references
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Citations

This article has been cited 9 times.
  1. Lo Feudo CM, Stucchi L, Conturba B, Stancari G, Zucca E, Ferrucci F. Equine Gastric Ulcer Syndrome affects fitness parameters in poorly performing Standardbred racehorses. Front Vet Sci 2022;9:1014619.
    doi: 10.3389/fvets.2022.1014619pubmed: 36504861google scholar: lookup
  2. Munsterman AS, Dias Moreira AS, Marqués FJ. Evaluation of a Chinese herbal supplement on equine squamous gastric disease and gastric fluid pH in mares. J Vet Intern Med 2019 Sep;33(5):2280-2285.
    doi: 10.1111/jvim.15603pubmed: 31441559google scholar: lookup
  3. Tesena P, Yingchutrakul Y, Roytrakul S, Wongtawan T, Angkanaporn K. Serum protein expression in Equine Glandular Gastric Disease (EGGD) induced by phenylbutazone. J Vet Med Sci 2019 Mar 20;81(3):418-424.
    doi: 10.1292/jvms.18-0679pubmed: 30674748google scholar: lookup
  4. Sauer FJ, Bruckmaier RM, Ramseyer A, Vidondo B, Scheidegger MD, Gerber V. Diagnostic accuracy of post-ACTH challenge salivary cortisol concentrations for identifying horses with equine glandular gastric disease. J Anim Sci 2018 Jun 4;96(6):2154-2161.
    doi: 10.1093/jas/sky074pubmed: 29762691google scholar: lookup
  5. Birkmann K, Junge HK, Maischberger E, Wehrli Eser M, Schwarzwald CC. Efficacy of omeprazole powder paste or enteric-coated formulation in healing of gastric ulcers in horses. J Vet Intern Med 2014 May-Jun;28(3):925-33.
    doi: 10.1111/jvim.12341pubmed: 24628650google scholar: lookup
  6. Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand 2014 Mar 13;56(1):13.
    doi: 10.1186/1751-0147-56-13pubmed: 24625291google scholar: lookup
  7. Fink C, Hembes T, Brehm R, Weigel R, Heeb C, Pfarrer C, Bergmann M, Kressin M. Specific localisation of gap junction protein connexin 32 in the gastric mucosa of horses. Histochem Cell Biol 2006 Mar;125(3):307-13.
    doi: 10.1007/s00418-005-0047-3pubmed: 16205941google scholar: lookup
  8. Tesena P, Vinijkumthorn R, Preuksathaporn T, Piyakul P, Chotikaprakal T, Sirireugwipas R, Wong-Aree K, Prapaiwan N. Evaluation of gastrointestinal tract lesions and serum malondialdehyde levels after repeated oral administration of phenylbutazone in horses. Vet Res Commun 2024 Aug;48(4):2343-2355.
    doi: 10.1007/s11259-024-10415-ypubmed: 38771448google scholar: lookup
  9. Williams Louie E, Nieto J, Wensley F, Morgan JM, Finno CJ, Berryhill EH. Efficacy of the oral supplement, Equine Omega Complete, for the prevention of gastric ulcers and alpha-tocopherol supplementation in horses. J Vet Intern Med 2023 Nov-Dec;37(6):2529-2534.
    doi: 10.1111/jvim.16877pubmed: 37775973google scholar: lookup
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