Equine pastern vasculitis in a horse associated with a multidrug-resistant Pseudomonas aeruginosa isolate.
Abstract: Equine pastern vasculitis is an uncommon disorder in horses. Underlying causes are difficult to assess, especially bacterial infections. Conclusions: A 13-year-old French saddle gelding horse presented for evaluation of a six weeks history of pastern dermatitis. Histopathological examination of skin biopsy samples revealed small vessel vasculitis. A pure growth of a multidrug-resistant Pseudomonas aeruginosa (MRPA) was obtained from a deep skin biopsy. Clinical remission was observed after a six week course of enrofloxacin and lesions did not recur. Conclusions: To the best of the authors' knowledge, this is the first report of a pastern vasculitis associated with MRPA and successfully treated with a six week course of enrofloxacin. Background: La vascularite du paturon est une atteinte rare chez le cheval. Les causes sous-jacentes sont difficiles à évaluer, en particulier les infections bactériennes. RÉSUMÉ CLINIQUE: Un cheval de selle français de 13 ans est présenté en consultation pour dermatite des paturons évoluant depuis six semaines. L'examen histopathologique des biopsies cutanées a révélé une vascularite des petits vaisseaux. Une croissance pure de Pseudomonas aeruginosa multi-résistantes (MRPA) a été obtenue à partir des biopsies profondes. Une rémission clinique a été observée après six semaines d'enrofloxacine et les lésions n'ont pas récidivé. Unassigned: A la connaissance des auteurs, ceci est la première description d'une vascularite des paturons associée à MRPA et traitée avec succès avec six semaines d'enrofloxacine. INTRODUCCIÓN: la vasculitis de la cuartilla equina es un trastorno poco frecuente en los caballos. Las causas subyacentes son difíciles de evaluar, especialmente las infecciones bacterianas. RESUMEN CLÍNICO: un caballo castrado francés de silla de 13 años se presentó para evaluación por un historial de seis semanas de dermatitis de la cuartilla. El examen histopatológico de las muestras de biopsia de piel reveló vasculitis de vasos pequeños. Se obtuvo un crecimiento puro de Pseudomonas aeruginosa resistente a múltiples fármacos (MRPA) a partir de una biopsia de piel profunda. Se observó remisión clínica después de un curso de seis semanas de enrofloxacina y las lesiones no volvieron a aparecer. CONCLUSIONES E IMPORTANCIA CLÍNICA: a entender de los autores, este es el primer informe de una vasculitis de cuartilla asociada con MRPA y tratada con éxito con un ciclo de enrofloxacina de seis semanas. Unassigned: Die equine Vaskulitis der Fesselregion ist eine seltene Erkrankung bei Pferden. Zugrundeliegende Ursachen sind schwierig zu beurteilen, vor allem bakterielle Infektionen. Unassigned: Ein 13 Jahre alter Französischer Sattelpferdwallach wurde zur Evaluierung einer sechs Wochen andauernden Fesseldermatitis vorgestellt. Die histopathologische Untersuchung einer Hautbiopsie zeigte eine Vaskulitis der kleinen Blutgefässe. Aus einer tiefen Hautbiopsie wurde reines Wachstum eines multi-resistenten Pseudomonas aeruginosa (MRPA) festgestellt. Es kam nach einer sechs Wochen andauernder Behandlung mit Enrofloxacin zur klinischen Remission und die Veränderungen traten nicht wieder auf. Unassigned: Nach bestem Wissen der Autoren handelt es sich hierbei um den ersten Bericht einer Fesselvaskulitis im Zusammenhang mit MRPA, die erfolgreich mit einer sechs Wochen langen Gabe von Enrofloxacin behandelt wurde. 背景: 馬の繋血管炎は、馬では珍しい疾患である。 根本的な原因、特に細菌感染の評価は困難である。 臨床概要: 6週間の繋皸の病歴の評価のために13歳の去勢セルフランセが示された。 皮膚生検サンプルの組織病理学的検査により、小血管血管炎が明らかになった。 多剤耐性緑膿菌(MRPA)の純培養が深在部皮膚生検から得られた。 エンロフロキサシン投与6週間経過後に臨床的寛解が観察され、病変は再発しなかった。 結論と臨床的重要性: 著者の知る限り、MRPAに関連し、6週間のエンロフロキサシンによる治療が成功した馬の繋血管炎の最初の報告である。. 背景: 马的系部血管炎是一种罕见的疾病。潜在的原因很难评估,尤其是细菌感染。 临床总结: 一匹13岁法国阉割骑乘马,因六周病史的系部皮炎而就诊。皮肤活检样本的组织病理学检查显示小血管的血管炎。皮肤深部活检样本培养出单纯的多耐药铜绿假单胞菌(MRPA)。经过六周恩诺沙星治疗,可观察到临床症状缓解而且病变没有复发。 结论和临床重要性: 据作者所知,这是第一例MRPA引起系部血管炎,并用六周恩诺沙星治疗达到治愈的报告。. A dermatite de quartela é um distúrbio incomum em cavalos. As causas subjacentes são difíceis de identificar, principalmente nas infecções bacterianas. ACHADOS CLÍNICOS: Um cavalo de sela francês castrado de 13 anos de idade foi apresentado para avaliação de dermatite de quartela com seis semanas de evolução. O exame histopatológico de amostras de biópsia de pele revelou vasculite de pequenos vasos. Houve crescimento de uma colônia pura de Pseudomonas aeruginosa multirresistente (MRPA) a partir de uma biópsia de pele profunda. A remissão clínica foi observada após um curso de seis semanas de enrofloxacina e as lesões não recidivaram. CONCLUSÕES E IMPORTÂNCIA CLÍNICA: De acordo com o conhecimento dos autores, este é o primeiro relato de vasculite de quartela associada à MRPA e tratada com sucesso com um curso de seis semanas de enrofloxacina.
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Publication Date: 2020-01-12 PubMed ID: 31930603DOI: 10.1111/vde.12830Google Scholar: Lookup
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Summary
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This research discusses a case of pastern vasculitis in a 13-year-old French saddle gelding horse, caused by a multidrug-resistant form of Pseudomonas aeruginosa (MRPA). The horse’s skin condition improved after a six-week treatment with enrofloxacin, with no recurrence of the lesions. This is reportedly the first case of pastern vasculitis linked to MRPA and successfully treated with enrofloxacin.
Introduction and Case Description
- Equine pastern vasculitis is a rare disorder in horses, often challenging to diagnose due to the complexity of underlying causes.
- This research focuses on a unique case, a 13-year-old gelding horse presenting a six-week history of pastern dermatitis, a skin condition.
Methodology and Findings
- The horse’s skin biopsies were examined, revealing small vessel vasculitis, a condition where blood vessels become inflamed.
- Upon biopsying deeper skin layers, a pure growth of multidrug-resistant Pseudomonas aeruginosa (MRPA) was found. MRPA is a commonly found bacteria, but in this multidrug-resistant form, it is harder to treat effectively.
Treatment and Results
- The horse was put on a six-week course of enrofloxacin, a broad-spectrum antibiotic known to be effective against a wide range of bacterial infections.
- After six weeks of treatment, the horse showed apparent signs of clinical remission, indicating the treatment’s effectiveness.
- The horse’s skin condition significantly improved, and, importantly, no recurrence in lesions was observed.
Conclusions and Clinical Importance
- This research marks the first case of pastern vasculitis associated with a multidrug-resistant form of Pseudomonas aeruginosa, highlighting the potential for unusual bacterial infections to cause skin conditions in horses.
- The successful treatment of the condition with a six-week course of the antibiotic enrofloxacin underscores this drug’s possible use in similar cases.
Cite This Article
APA
Panzuti P, Rocafort Ferrer G, Mosca M, Pin D.
(2020).
Equine pastern vasculitis in a horse associated with a multidrug-resistant Pseudomonas aeruginosa isolate.
Vet Dermatol, 31(3), 247-e55.
https://doi.org/10.1111/vde.12830 Publication
Researcher Affiliations
- UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
- UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
- UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
- UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.
MeSH Terms
- Animals
- Anti-Bacterial Agents / therapeutic use
- Drug Resistance, Multiple, Bacterial
- Histological Techniques
- Horse Diseases / drug therapy
- Horse Diseases / microbiology
- Horses
- Male
- Pseudomonas Infections / complications
- Pseudomonas Infections / drug therapy
- Pseudomonas Infections / veterinary
- Pseudomonas aeruginosa / drug effects
- Pseudomonas aeruginosa / isolation & purification
- Pseudomonas aeruginosa / pathogenicity
- Skin / pathology
- Vasculitis / drug therapy
- Vasculitis / microbiology
- Vasculitis / veterinary
References
This article includes 6 references
- Scott D.W., Miller W.H.. Equine Dermatology, 2nd edition. Maryland Heights, MO: Saunders Elsevier, 2011; 335-351.
- Psalla D, Rüfenacht S, Stoffel MH. Equine pastern vasculitis: a clinical and histopathological study. Vet J 2013; 198: 524-530.
- White SD, Affolter VK, Dewey J. Cutaneous vasculitis in equines: a retrospective study of 72 cases. Vet Dermatol 2009; 20: 600-606.
- Risberg ÅI, Webb CB, Cooley AJ. Leucocytoclastic vasculitis associated with Staphylococcus intermedius in the pastern of a horse. Vet Rec 2005; 156: 740-743.
- Pagnoux C, Cohen P, Guillevin L. Vasculitides secondary to infections. Clin Exp Rheumatol 2006; 24 (Suppl 41): S71-81.
- Köhler T, Kok M, Michea-Hamzehpour M. Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1996; 40: 2,288-2,290.
Citations
This article has been cited 4 times.- Xiao YY, Lu AL, Mo HY, He ZD, Wen JL, Yin X. Clinical value of metagenomic next-generation sequencing in patients with connective tissue diseases co-infections: a single-center study from southern hospital in China. Clin Rheumatol 2025 Aug;44(8):3265-3275.
- Strompfová V, Štempelová L. Composition and diversity of 16S rRNA based skin bacterial microbiome in healthy horses. Vet Res Commun 2024 Aug;48(4):2847-2855.
- Thomson P, Pareja J, Núñez A, Santibáñez R, Castro R. Characterization of microbial communities and predicted metabolic pathways in the uterus of healthy mares. Open Vet J 2022 Nov-Dec;12(6):797-805.
- Nikolaisen NK, Ronaghinia AA, Lassen DCK, Chehabi CN, Lindegaard M, Struve T, Chriél M, Damborg P, Kahlmeter G, Jensen LB, Pedersen K. Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink. Front Vet Sci 2020;7:544594.
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