Equine pituitary adenoma: a functional and morphological study.
Abstract: Clinico-pathological correlations in horses with pituitary adenomas are poorly understood. This paper describes the functional and morphological features of five cases of equine pituitary adenoma and of a case of multinodular pituitary hyperplasia. New findings reported include immunoreactivity for beta-lipotropin (beta-LPH), beta-melanocyte-stimulating hormone (beta-MSH), gamma 3-MSH, prolactin (PRL), and follicle-stimulating hormone (FSH) in neoplastic cells of the pituitary adenoma; and, in the multinodular hyperplasia, beta-LPH, beta-endorphin (beta-END), alpha-MSH, beta-MSH, gamma 3-MSH and FSH immunoreactivity. It is suggested that the equine pituitary syndrome does not correspond to human Cushing's disease, as generally accepted, but is related to the overproduction of several pro-opiomelanocortin (POMC)-derived peptides by the cells of the tumour or hyperplastic nodules.
Publication Date: 1993-08-01 PubMed ID: 8245232DOI: 10.1016/s0021-9975(08)80260-5Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The study focuses on understanding the clinical and pathological correlations in horses with pituitary adenomas across five notable cases and one case of multinodular pituitary hyperplasia. The highlighted discovery is that the equine pituitary syndrome does not align with human Cushing’s disease, contrary to popular belief, but instead relates to the overproduction of various pro-opiomelanocortin (POMC)-derived peptides by tumor cells or hyperplastic nodules.
Introduction
In this study, the funcitonal and morphological aspects of equine pituitary adenoma are investigated. Pituitary adenomas in horses and the associated clinical-pathological correlations have been obscure. Researchers examined these aspects through a series of case studies.
Clinical Case Analysis
- Five equine pituitary adenoma cases and one case of multinodular pituitary hyperplasia were studied. The horses were evaluated based on their immunoreactivity for certain hormones.
- Researchers reported new findings, including detection of immunoreactivity for beta-Lipotropin (Beta-LPH), beta-melanocyte-stimulating hormone (Beta-MSH), gamma 3-MSH, prolactin (PRL), and follicle-stimulating hormone (FSH) in the neoplastic cells of the pituitary adenoma.
- In the multinodular hyperplasia case, Beta-LPH, beta-endorphin (Beta-END), alpha-MSH, Beta-MSH, gamma 3-MSH and FSH showed immunoreactivity.
Key Findings
- One of the significant findings of this research is the suggestion that equine pituitary syndrome is not equivalent to human Cushing’s disease, as conventionally believed.
- Instead, it is associated with the overproduction of several pro-opiomelanocortin (POMC)-derived peptides by the cells of the tumor or cases of hyperplastic nodules.
Implication of Findings
- This distinction in equine pituitary syndromes could influence the approach to diagnosing and treating this condition in horses.
- Further research is required to explore these findings, which provide new insight into equine pituitary syndrome and could open up possibilities for novel therapeutics.
Cite This Article
APA
Boujon CE, Bestetti GE, Meier HP, Straub R, Junker U, Rossi GL.
(1993).
Equine pituitary adenoma: a functional and morphological study.
J Comp Pathol, 109(2), 163-178.
https://doi.org/10.1016/s0021-9975(08)80260-5 Publication
Researcher Affiliations
- Institute of Animal Pathology, University of Berne, Switzerland.
MeSH Terms
- Adenoma / blood
- Adenoma / metabolism
- Adenoma / pathology
- Adenoma / veterinary
- Adrenal Cortex / pathology
- Animals
- Biomarkers, Tumor / analysis
- Circadian Rhythm / physiology
- Cushing Syndrome
- Female
- Horse Diseases / blood
- Horse Diseases / pathology
- Horse Diseases / physiopathology
- Horses
- Humans
- Hyperplasia
- Insulin Resistance
- Male
- Microscopy, Electron
- Pituitary Gland, Anterior / pathology
- Pituitary Hormones, Anterior / analysis
- Pituitary Neoplasms / blood
- Pituitary Neoplasms / metabolism
- Pituitary Neoplasms / pathology
- Pituitary Neoplasms / veterinary
- Pro-Opiomelanocortin / metabolism
Citations
This article has been cited 5 times.- Nitzsche AM, Fey K, Büttner K, Gröf M, Staszyk C. The Gingiva of Horses With Pituitary Pars Intermedia Dysfunction: A Macroscopic Anatomical Evaluation.. Front Vet Sci 2021;8:786971.
- Gehlen H, Schwarz B, Bartmann C, Gernhardt J, Stöckle SD. Pituitary Pars Intermedia Dysfunction and Metabolic Syndrome in Donkeys.. Animals (Basel) 2020 Dec 8;10(12).
- Hatazoe T, Kawaguchi H, Hobo S, Misumi K. Pituitary pars intermedia dysfunction (equine Cushing's disease) in a Thoroughbred stallion: a single report.. J Equine Sci 2015;26(4):125-8.
- Sgorbini M, Panzani D, Maccheroni M, Corazza M. Equine cushing-like syndrome: diagnosis and therapy in two cases.. Vet Res Commun 2004 Aug;28 Suppl 1:377-80.
- Panzani D, Vannozzi I, Sgorbini M, Corazza M, Rota A, Pacini M. Embryo recovery rate in a mare affected by Cushing's syndrome.. Vet Res Commun 2003 Sep;27 Suppl 1:619-21.
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